4 replies to this topic

[joelcairo]

I've done enough research to be impressed with sulforaphane as an anticancer supplement. In addition to its direct effects, it attacks cancer epigenetically, via DNA demethylation and HDAC inhibition. I'm currently healthy but at (extremely) high risk for a certain kind of cancer, so I've decided I want to be closer to a therapeutic dose than a maintenance dose. I'm currently taking 1 BroccoMax capsule per day, containing 375 mg broccoli seed extract, providing 30 mg sulforaphane glucosinolate (SGS).

I'm going crazy because a lot of articles and even published studies don't properly distinguish sulforaphane from SGS. And some in vivo studies I'm looking at measure the sulforaphane in micromoles rather than mg or mcg, and I have no idea how to do the conversion. AND I just found out that because BroccoMax relies on SGS from seeds instead of sprouts, it doesn't contain an enzyme that is required for optimal absorption of sulforaphane - myrosinase.
http://www.nutraingr...still-effective

Just great. This is curcumin and resveratrol all over again. I bought a package of broccoli sprouts and for the time being and going to munch some along with my BroccoMax pill, but in the long run:

What's the best formulation for bioavailability? Broccoli sprout extract, or is there a catch with that too?

What is a realistic therapeutic dose to shoot for?

Thanks in advance for any insight you can provide.

[hamishm00]

What about the other anti-cancer substances in cruciferous vegetables like indole 3 carbonol and 3,3'-Diindolymethane abd 4’,5,7-trihydroxyflavone (Apigenin)?

Isothiocyanates, sulphoraphane and SGS may only be part of the equation?

[Mind]

I can understand your concern and desire to take the supplement, but maybe it would be better just to eat more broccoli and other veggies that have sulphoraphane.

[joelcairo]

I do eat cruciferous vegetables every day, but that's a lotta broccoli. Eating broccoli sprouts would be somewhat more efficient, but would still require a certain amount of dedication to the task. Then there's still the question of how much to eat to register a clinically measurable effect.

Indole 3 carbinol and apigenin also look healthful, but based on what I've read my primary interest is sulforaphane.

[frederickson]

my understanding is that one cup of broccoli sprouts inhibited HDAC production by 70% (2007 Seminars in Cancer Biology). that is a relatively reasonable dose, imo. this is not to say that supplementation may not be worth it, however.