I stumbled upon this molecules "JTP-4819" while researching into the mechanism of Pramiracetam.
Chemical structure and purchase(?)
-On a side note Pramiracetam works by modulating the enzyme prolyl endopeptidase which is one of the primary enzymes involved in regulating learning and cholingeric systems.
Anyways, when googling scholarly papers for prolyl endopeptidase, I came across JTP-4819
There is very few information I could find on this molecule, nor could I find any place to purchase it for research purposes. Nearly all articles relating to this molecule go back in the 90's
If anyone knows anything about this or would like to help me look into it, then please do! It sounds very interesting and I don't think there's been much if any testing on humans.
I have a theory that, there are 2 potential side effects this substance could have on brain chemistry due to it's mechanism... just theories.
1)It could cause more of the enzyme prolyl endopeptidase to be released to make up for the inhibited ones... inevitably resulting in even higher levels of ACh.
2)It could cause ACh to be produced at an endless rate.
Now these are just optimistic shots in the dark, there could always be bad things that happen... but tests on rats show only positives. Though, in terms of how it affects the mind... testing on rats can only tell us so much. Really, how much can a rat learn about navigating a maze lol.
Some other papers on the substance:
After the behavioral experiment, the choline acetyltransferase (ChAT) activity and 3H-pirenzepine binding (Kd, Bmax) in the residual hippocampus and cerebral cortex were analyzed. Neither parameter was significantly affected by JTP-4819. In conclusion, JTP-4819 can improve both learning and relearning deficits of spatial memory in DH-lesioned rats, postulating that enhancement of neuropeptide activity via PEP inhibition may be involved in the mechanism of action of JTP-4819.
A study on people:
Gradually returned...... sounds like it provides a boost and the brain slowly reverts back to it's previous state... but that's only from 4 days. By the sound of it's effects, this sound like it would be a phenomenal Nootropic! But how would it's effects and actions compare to that of Pramiracetam since they work on the same enzyme?
Edited by OpenStrife, 30 June 2012 - 07:35 AM.