7 replies to this topic

[Danail Bulgaria]

Does anybody know where can be red scientific researches over cryonics and criobiology? Thanks in advance for the answers.

[Brain_Ischemia]

Sadly, vitrification/cryopreservation research published in peer-reviewed journals is typically restricted to embryos (or organs at best).
http://www.ncbi.nlm....m=vitrification

...on the other hand, as you can see in the above link, the growth of the number of publications involving such research appears to be accelerating (might be my naive optimism).

If you're interested in information regarding the history of developments in whole body and neuropreservation, the inimitable Mike Darwin is your man (there is perhaps no single person in the entire world who has more knowledge and personal experience regarding cryonics).
http://chronopause.c...the-cat-part-1/
http://chronopause.c...itation-part-1/
http://chronopause.c...chnique-part-1/
http://chronopause.c...patient-part-1/
http://chronopause.c...yopreservation/
http://chronopause.c...rt-data-part-i/
http://chronopause.c...failure-part-1/
http://chronopause.c...d-risks-part-1/

Darwin has essentially pulled back the curtain on cyronics as far as he can; the lay public no longer has any excuses.

Edited by caliban, 17 April 2018 - 07:33 AM.
c

[Danail Bulgaria]

Thank You for the information. It is clear for me, that You have more experience from me in searching researches about cryonics. Have You met a research, that has successfully vitrified and recovered a mamal, even a small one, such as a mouse or a rat?

[Brain_Ischemia]

The following probably represents the best that's been achieved so far in whole mammal cryoincs research-

http://www.alcor.org...mler-Annals.pdf
http://www.alcor.org.../tbwcanine.html
http://patft.uspto.g...03&RS=6,274,303
http://www.cryonet.o...p.cgi?msg=12464
http://www.alcor.org...servation1.html


Darwin and colleagues were able to successfully revive dogs after at least five hours of bloodless perfusion (the dogs fully recovered), a record which apparently still stands. The mid-90's saw dogs taken to subzero temperatures and then successfully rewarmed. 21st Century Medicine has also demonstrated recovery without brain damage from 16-minutes of normothermic ischemia, another standing record.

Of note-
21st CM's special high molarity CPA solution, M-22, has been demonstrated to prevent ice formation in brain tissue, and samples show "excellent" preservation of the fine structures responsible for long-term memory. More on that in the "Does Personal Identity Survive Cryopreservation" link in the above post.

I'll add that, for me *personally*, what matters most right now is the degree of undamaged preservation of neuronal structure; the technology to recover patients will undoubtedly be a work-in-progress for the forseeable future, but lacking demonstrable recovery *right now*, the technological capability to preserve the brain as well as possible is more important for now IMHO..

Edited by caliban, 17 April 2018 - 07:33 AM.
c

[mikeb80]

The articles by Mike Darwin are very enlightening.
I owe to him the 80% of my knowledges about cryonics.

Edited by caliban, 17 April 2018 - 07:34 AM.
c

[benbest]

Does anybody know where can be red scientific researches over cryonics and criobiology? Thanks in advance for the answers.

I have a couple of publications in PubMed on the subject of cryonics

http://www.ncbi.nlm....d?term=best bp [au]

http://www.cryonics....stification.pdf

and most of the information in the cryonics section of my website is technical

http://www.benbest.c...s/cryonics.html

with many referenced to peer-reviewed publications.

[Danail Bulgaria]

thanks for the answers

[Brain_Ischemia]

I have a couple of publications in PubMed on the subject of cryonics

Thanks as always, Ben.