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NSI-189

nsi-189

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#61 daouda

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Posted 13 April 2013 - 04:29 AM

This stuff sounds like it could really help with fluoroquinolone-induced brain damage... I'd love to be in for a group buy (if within my financial reach)

#62 ScienceGuy

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Posted 13 April 2013 - 05:00 AM

Interested in this. I can wait with IDRA-21 after I tryout PRL-8-53. What are the doses for this and some quotes for 10g or 100g?


In the clinical trial they are using doses from 40 to 120 mg/ day

I sent an email yesterday for a quote on 30g... No reply yet. Any idea how long they take to reply ?


what did you sent them ? the molecular structure ?

120 mg * 28 (days) =3360/1000 = 3,360 grams 100 grams /3,360 grams= we need 29,76 persons for group buy.


To clarify, please kindly note that you have used COMMAS there instead of FULL STOPS... I initially read "3,360" as THREE THOUSAND... but it is of course 3.36 GRAMS :)

So basically, with the 120mg / day dosage a group buy of 100 GRAMS would allow for 29 - 30 PARTICIPANTS (without anyone splitting quantities further which can of course occur); and 50 GRAMS would allow for circa 15 PARTICIPANTS :)

I will obtain quotations from the same CUSTOM SYTHESIS LAB whom carried out the COLURACETAM synthesis for me (which was synthesized to 99.9% PURITY) for custom synthesis of both NSI-189 and IDRA-21... BTW it is a EUROPEAN LAB, and not CHINESE... They are also pretty ingenious regards figuring out SYNTHESIS ROUTES for even the most complex chemicals... I will feedback ASAP :)

I would be happy to manage the custom synthesis of either one or other or both of these two substances as part of a GROUP BUY ;)

I should add that I don't want to steal any thunder away from HADORA who started all this interest in NSI-189... this is HIS thread after all :)

Edited by ScienceGuy, 13 April 2013 - 05:11 AM.

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#63 Reformed-Redan

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Posted 13 April 2013 - 05:07 AM

Interested in this. I can wait with IDRA-21 after I tryout PRL-8-53. What are the doses for this and some quotes for 10g or 100g?


In the clinical trial they are using doses from 40 to 120 mg/ day

I sent an email yesterday for a quote on 30g... No reply yet. Any idea how long they take to reply ?


what did you sent them ? the molecular structure ?

120 mg * 28 (days) =3360/1000 = 3,360 grams 100 grams /3,360 grams= we need 29,76 persons for group buy.


To clarify, please kindly note that you have used COMMAS there instead of FULL STOPS... I initially read "3,360" as THREE THOUSAND... but it is of course 3.36 GRAMS :)

So basically, with the 120mg / day dosage a group buy of 100 GRAMS would allow for 29 - 30 PARTICIPANTS (without anyone splitting quantities further which can of course occur); and 50 GRAMS would allow for circa 15 PARTICIPANTS :)

I will obtain quotations from the same CUSTOM SYTHESIS LAB whom carried out the COLURACETAM synthesis for me (which was synthesized to 99.9% PURITY) for custom synthesis of both NSI-189 and IDRA-21... BTW it is a EUROPEAN LAB, and not CHINESE... They are also pretty ingenious regards figuring out SYNTHESIS ROUTES for even the most complex chemicals... I will feedback ASAP :)

I would be happy to manage the custom synthesis of either one or other or both of these two substances as part of a GROUP BUY ;)

ScienceGuy, you always deliver. IDRA-21 here we come! Sweet.
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#64 golden1

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Posted 13 April 2013 - 05:36 AM

I like where this is going. IDRA-21 is cool, seems like a much more studied sunifiram. .. but NSI-189, now that seems pretty gangster(this is a positive thing.. hahh). depending on the price per person which I imagine could vary a ton I'd love to try NSI-189.. have a feeling it will be cheaper to synthesize looking at each of the structures, but I'm not a chemist so forget I said that.

#65 Megatrone

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Posted 13 April 2013 - 10:01 AM

Everything for intelligence gains! Let's hope we have developed ingenious traits in 10 years ;)

#66 Megatrone

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Posted 13 April 2013 - 10:39 AM

Should we go with NSI-189 or IDRA-21 first?

#67 spookytooth

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Posted 13 April 2013 - 11:24 AM

Since NSI-189 might be able to induce permanent positive changes I find it to be much more interesting than IDRA-21 which would be just another nootropic amongst the 100s we already have at our disposal.
I would be in for a group buy of NSI-189.

Edited by spookytooth, 13 April 2013 - 11:28 AM.


#68 hadora

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Posted 13 April 2013 - 11:48 AM

In my humble opinion Ampakine are way overhyped most of them didn't even get past phase 1 clinical trial

#69 hadora

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Posted 13 April 2013 - 11:53 AM

Interested in this. I can wait with IDRA-21 after I tryout PRL-8-53. What are the doses for this and some quotes for 10g or 100g?


In the clinical trial they are using doses from 40 to 120 mg/ day

I sent an email yesterday for a quote on 30g... No reply yet. Any idea how long they take to reply ?


what did you sent them ? the molecular structure ?

120 mg * 28 (days) =3360/1000 = 3,360 grams 100 grams /3,360 grams= we need 29,76 persons for group buy.


To clarify, please kindly note that you have used COMMAS there instead of FULL STOPS... I initially read "3,360" as THREE THOUSAND... but it is of course 3.36 GRAMS :)

So basically, with the 120mg / day dosage a group buy of 100 GRAMS would allow for 29 - 30 PARTICIPANTS (without anyone splitting quantities further which can of course occur); and 50 GRAMS would allow for circa 15 PARTICIPANTS :)

I will obtain quotations from the same CUSTOM SYTHESIS LAB whom carried out the COLURACETAM synthesis for me (which was synthesized to 99.9% PURITY) for custom synthesis of both NSI-189 and IDRA-21... BTW it is a EUROPEAN LAB, and not CHINESE... They are also pretty ingenious regards figuring out SYNTHESIS ROUTES for even the most complex chemicals... I will feedback ASAP :)

I would be happy to manage the custom synthesis of either one or other or both of these two substances as part of a GROUP BUY ;)

I should add that I don't want to steal any thunder away from HADORA who started all this interest in NSI-189... this is HIS thread after all :)


i don't own anything lol this thread belong to everyone, anyone who can add his contribution is more than welcome :)

#70 izan82

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Posted 13 April 2013 - 12:59 PM

Interested in this. I can wait with IDRA-21 after I tryout PRL-8-53. What are the doses for this and some quotes for 10g or 100g?


In the clinical trial they are using doses from 40 to 120 mg/ day

I sent an email yesterday for a quote on 30g... No reply yet. Any idea how long they take to reply ?


what did you sent them ? the molecular structure ?

120 mg * 28 (days) =3360/1000 = 3,360 grams 100 grams /3,360 grams= we need 29,76 persons for group buy.


To clarify, please kindly note that you have used COMMAS there instead of FULL STOPS... I initially read "3,360" as THREE THOUSAND... but it is of course 3.36 GRAMS :)

So basically, with the 120mg / day dosage a group buy of 100 GRAMS would allow for 29 - 30 PARTICIPANTS (without anyone splitting quantities further which can of course occur); and 50 GRAMS would allow for circa 15 PARTICIPANTS :)

I will obtain quotations from the same CUSTOM SYTHESIS LAB whom carried out the COLURACETAM synthesis for me (which was synthesized to 99.9% PURITY) for custom synthesis of both NSI-189 and IDRA-21... BTW it is a EUROPEAN LAB, and not CHINESE... They are also pretty ingenious regards figuring out SYNTHESIS ROUTES for even the most complex chemicals... I will feedback ASAP :)

I would be happy to manage the custom synthesis of either one or other or both of these two substances as part of a GROUP BUY ;)

I should add that I don't want to steal any thunder away from HADORA who started all this interest in NSI-189... this is HIS thread after all :)

i know, but here in holland we use commas. take it easy, ;).

Should we go with NSI-189 or IDRA-21 first?

nsi-189, no question about that.

Edited by izan82, 13 April 2013 - 12:57 PM.


#71 Reformed-Redan

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Posted 13 April 2013 - 03:43 PM

Since NSI-189 might be able to induce permanent positive changes I find it to be much more interesting than IDRA-21 which would be just another nootropic amongst the 100s we already have at our disposal.
I would be in for a group buy of NSI-189.

Agreed, although we still don't know the cost of this compound. IDRA-21 can wait; but, it comes right after this.

#72 daouda

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Posted 13 April 2013 - 04:32 PM

Posted Imagespookytooth, on 13 April 2013 - 11:24 AM, said:

Since NSI-189 might be able to induce permanent positive changes I find it to be much more interesting than IDRA-21 which would be just another nootropic amongst the 100s we already have at our disposal.
I would be in for a group buy of NSI-189.
Agreed, although we still don't know the cost of this compound. IDRA-21 can wait; but, it comes right after this.


+1
NSI-189 (along with dihexa) seems to hold great hopes for therapeutic (as in cure, not "manage") purposes...

Edited by daouda, 13 April 2013 - 04:33 PM.


#73 sunshinefrost

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Posted 13 April 2013 - 05:31 PM

Interested in this. I can wait with IDRA-21 after I tryout PRL-8-53. What are the doses for this and some quotes for 10g or 100g?


In the clinical trial they are using doses from 40 to 120 mg/ day

I sent an email yesterday for a quote on 30g... No reply yet. Any idea how long they take to reply ?


what did you sent them ? the molecular structure?


Yeah, i sent them the cid, the chemical formula, the iupac name, And even a picture of the molecule. Still no answer.

#74 Reformed-Redan

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Posted 13 April 2013 - 05:57 PM

These guys look legit. We were going to go with them with the PRL-8-53 synth; but, went with Novochemy. For this group buy to be feasible you'd likely have to go with a supplier that wont charge that much.

sun-shinechem.com

Interested in this. I can wait with IDRA-21 after I tryout PRL-8-53. What are the doses for this and some quotes for 10g or 100g?


In the clinical trial they are using doses from 40 to 120 mg/ day

I sent an email yesterday for a quote on 30g... No reply yet. Any idea how long they take to reply ?


what did you sent them ? the molecular structure?


Yeah, i sent them the cid, the chemical formula, the iupac name, And even a picture of the molecule. Still no answer.

Can you send an inquiry to the above listed supplier? I don't have time atm to look into price quotes.

#75 mait

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Posted 13 April 2013 - 06:11 PM

If group buy is initiated I would like to be part of it.

Edited by mait, 13 April 2013 - 06:12 PM.


#76 sunshinefrost

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Posted 13 April 2013 - 06:15 PM

I'll fill a quotation form today for sunshinechem. I'm gessing i'll receive no replies before monday.

#77 Reformed-Redan

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Posted 13 April 2013 - 06:28 PM

I'll fill a quotation form today for sunshinechem. I'm gessing i'll receive no replies before monday.

Yeah, they seem legit. We want to find a supplier that wont make this group buy cost prohibitive.

#78 sunshinefrost

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Posted 13 April 2013 - 08:07 PM

I sent a quotation request to sun-shinechem. Still waiting for novochemy.

#79 Colli

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Posted 13 April 2013 - 11:55 PM

Would also like to be part of a group buy for this.

#80 sunshinefrost

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Posted 13 April 2013 - 11:57 PM

So far i am counting 14 people interested in the group buy.

#81 Hebbeh

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Posted 13 April 2013 - 11:59 PM

So far i am counting 14 people interested in the group buy.


Count me in.

#82 sunshinefrost

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Posted 14 April 2013 - 12:05 AM

I got a reply from sunshinechem. They can synthtise it !

The price is 2580 for 100 grams with a 4 to 5 weeks lead time.

We are now 15. Roughly 170$ per person so far.

Honestly, i think it's worth it.

#83 sunshinefrost

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Posted 14 April 2013 - 12:26 AM

Can anyone confirm if the follong is correct ? Just want to make sure.

Molecular Formula: C22H30N4O
Molecular Weight: 366.4998
IUPAC Name: (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone

I also sent them this

Attached Files


Edited by sunshinefrost, 14 April 2013 - 12:28 AM.


#84 Metagene

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Posted 14 April 2013 - 12:28 AM

I'm down too.

Edited by Metagene, 14 April 2013 - 12:29 AM.


#85 Reformed-Redan

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Posted 14 April 2013 - 12:55 AM

If 30 to 35 were interested i could cough up the money.


#86 rikelme

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Posted 14 April 2013 - 12:55 AM

In too. 16 so far ?

#87 daouda

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Posted 14 April 2013 - 12:55 AM

OK, I think I should try this while I still can, please count me in (in case you hadn't)

Edited by daouda, 14 April 2013 - 12:56 AM.


#88 sunshinefrost

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Posted 14 April 2013 - 01:03 AM

In too. 16 so far ?


Yep 16 ! Maybe scienceguy comes back with a cheaper pricing. I'm not waiting a month to order this. If we dont have a better price within a few days i will ask all interested parties how much they would be willing to pay. We'll go from there but i want to make this happen fast. I have the funds to pay for it with a few members.

#89 Reformed-Redan

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Posted 14 April 2013 - 01:18 AM

In too. 16 so far ?


Yep 16 ! Maybe scienceguy comes back with a cheaper pricing. I'm not waiting a month to order this. If we dont have a better price within a few days i will ask all interested parties how much they would be willing to pay. We'll go from there but i want to make this happen fast. I have the funds to pay for it with a few members.

You won't get a better price with ScienGuy's supplier. They're top notch and charge extra. Might look around for cheaper suppliers from China; but, sunshine-chem was what we found to be a cheap and seemingly reliable source for the PRL-8-53 synth. However, "seemingly reliable" was not enough for us. We needed near certainty and went with Novochemy.

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#90 abelard lindsay

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Posted 14 April 2013 - 01:31 AM

Hey guys, dumb question: How exactly does this induce hippocampal neurogenesis?





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