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Dihexa: "it would take 10 million times as much BDNF to get as much new synapse formation as Dihexa."


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#541 megatron

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Posted 08 April 2014 - 04:33 PM

Found a video from Dr. Harding presenting this compound, in case anyone wants to know a bit more.

 

http://vimeo.com/89795497

 

Thanks dude! Is MM-201 Dihexa?


Edited by Megatrone, 08 April 2014 - 04:45 PM.


#542 neuroatypicow

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Posted 08 April 2014 - 09:01 PM

that's impressive!

i for one am not ashamed to admit that my current rope hang skills are sadly lacking; i'm quite looking forward to significant improvements in this area.


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#543 Adaptogen

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Posted 08 April 2014 - 09:34 PM

Found a video from Dr. Harding presenting this compound, in case anyone wants to know a bit more.

 

http://vimeo.com/89795497

 

awesome, the rope hang time clip at 17:52 is my favorite part



#544 formergenius

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Posted 09 April 2014 - 06:36 AM

Thanks dude! Is MM-201 Dihexa?

 

This study mentions both MM-201 and Dihexa, but I haven't read it, so I don't know whether they are synonymous. But perhaps you can extract that info from its context.

 

edit; Early in the video, he talks about how one of the earlier analogues reversed kainic acid induced hippocampal lesions (60-70% neuron loss). He also states that they were only active for 2-3 minutes. Now I'm curious; what does he mean by "reversed"? As in; the kainic acid induced 60-70% loss of neurons, after which the substance grew them back, and that within 3 minutes? What am I missing here?


Edited by formergenius, 09 April 2014 - 07:26 AM.


#545 foreseason

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Posted 09 April 2014 - 04:21 PM

Would Dihexa have any possible application in treating mood disorders?  Or is this simply cognitive enhancement?  Although I'm assuming there's some crossover between those two. 

 

Apologies if that's a stupid question.  I'm somewhat new to these forums . 



#546 Amorphous

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Posted 10 April 2014 - 03:46 AM

Would Dihexa have any possible application in treating mood disorders?  Or is this simply cognitive enhancement?  Although I'm assuming there's some crossover between those two. 

 

Apologies if that's a stupid question.  I'm somewhat new to these forums . 

 

That's a good point. I think Dr. Harding talked about the growth in the hippocampus area; in this case, would that be similar to NSI -189? Do they have the same MOA?



#547 formergenius

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Posted 10 April 2014 - 04:19 AM

While on the subject, take a look at this. Ketamine's anti-depressant effects appear to be mediated via its synaptogenic action. More articles supporting a synaptic theory of depression.


Edited by formergenius, 10 April 2014 - 04:19 AM.


#548 xks201

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Posted 10 April 2014 - 10:46 PM

Mood disorders can be caused by low bdnf.

#549 HappyShoe

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Posted 11 April 2014 - 08:28 PM

So, how do we let you know we want in, directly through the yahoo group? Should we also do the pay it square group as well?


Edited by HappyShoe, 11 April 2014 - 08:35 PM.


#550 xks201

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Posted 11 April 2014 - 08:51 PM

Pay via PayPal cjs2027@gmail.com
156 for us shipped
All non us 170 per gram

#551 HappyShoe

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Posted 11 April 2014 - 08:55 PM

Can I still get 2g for 306? Also do I check goods and services or friends and family?


Edited by HappyShoe, 11 April 2014 - 08:58 PM.


#552 xks201

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Posted 11 April 2014 - 09:33 PM

Friends and family. No fee that way. And yes if you are in the US. Add the shipping address in comments or via pm.

#553 Azz19

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Posted 14 April 2014 - 03:49 AM

Why is my membership approval for the yahoo group still pending? :(

#554 moomoo

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Posted 14 April 2014 - 01:05 PM

I would imagine that he means:

 

  • The early analogue reserved kainic acid induced hippocampal lesions
  • The early analogue was only active for 2-3 minutes

From that I'd assume that the drug had to be given almost continuously to reverse the lesions. There's nothing in what he says to assume that it reversed the lesions completely back to a previous state, but instead simply that the lesion damage started to be reversed and continued to do so when given the analogue.

 

 

 

 

Thanks dude! Is MM-201 Dihexa?

 

This study mentions both MM-201 and Dihexa, but I haven't read it, so I don't know whether they are synonymous. But perhaps you can extract that info from its context.

 

edit; Early in the video, he talks about how one of the earlier analogues reversed kainic acid induced hippocampal lesions (60-70% neuron loss). He also states that they were only active for 2-3 minutes. Now I'm curious; what does he mean by "reversed"? As in; the kainic acid induced 60-70% loss of neurons, after which the substance grew them back, and that within 3 minutes? What am I missing here?

 

 


Edited by moomoo, 14 April 2014 - 01:06 PM.


#555 xks201

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Posted 15 April 2014 - 03:22 AM

Why is my membership approval for the yahoo group still pending? :(

 

Just let 9 people in. cjs2027@gmail.com is the paypal email 

150/gram +

6 us shipping or

20 non us shipping

 

Buy still has some room. 



#556 Azz19

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Posted 15 April 2014 - 03:29 AM

Did you receive my payment? I sent you a PM but you haven't responded.
Payment sent from arran******@hotmail.com

#557 xks201

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Posted 15 April 2014 - 03:37 AM

Sorry - you didn't request a response in the PM and I didn't because I was inundated with NSI pms. Just replied to it though.

#558 Azz19

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Posted 15 April 2014 - 03:56 AM

Okay, many thanks.

#559 StevesPetRat

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Posted 15 April 2014 - 07:34 PM

Hi, I hope I did not miss the window on this compound. Just went to join group.

#560 xks201

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Posted 15 April 2014 - 10:22 PM

It is still open.

#561 Amorphous

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Posted 16 April 2014 - 12:22 AM

xks201, 

 

I didn't receive my confirmation of payment neither. 

Please confirm that. I am going to pm yountoo



#562 xks201

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Posted 16 April 2014 - 03:18 AM

Lol now I have multiple people who paid a month ago asking for confirmations. Guys I don't want to write out 100 confirmations. If you have a PayPal receipt I did receive it
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#563 Azz19

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Posted 16 April 2014 - 03:30 AM

Lol, sorry for starting this off.

#564 HappyShoe

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Posted 16 April 2014 - 04:38 AM

I'd like a pony infused with Dihexa. =D



#565 xks201

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Posted 16 April 2014 - 04:48 AM

Me too. Haha

#566 StevesPetRat

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Posted 16 April 2014 - 05:05 AM

By the way, will this be packed in dry ice?
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#567 Metagene

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Posted 21 April 2014 - 03:34 PM


Thanks dude! Is MM-201 Dihexa?


 
This study mentions both MM-201 and Dihexa, but I haven't read it, so I don't know whether they are synonymous. But perhaps you can extract that info from its context.
 
edit; Early in the video, he talks about how one of the earlier analogues reversed kainic acid induced hippocampal lesions (60-70% neuron loss). He also states that they were only active for 2-3 minutes. Now I'm curious; what does he mean by "reversed"? As in; the kainic acid induced 60-70% loss of neurons, after which the substance grew them back, and that within 3 minutes? What am I missing here?

From what I understand MM-201 is a direct AT4 agonist opposed to Dihexa's acting on HGF. Both improve rope hang times :)

Our laboratory has recently synthesized a metabolically stable AngIV analog that acts by way of the hepatocyte growth factor (HGF)/c-Met receptor system (133136) to overcome the motor dysfunctions that follow 6-OHDA-induced lesions of the substantia nigra pars compacta in the rat (unpublished results). This compound, called Dihexa, sig- nificantly improved both rope hang times and stride length over the course of a 48-day treatment period.



#568 HappyShoe

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Posted 22 April 2014 - 01:02 AM

what is the route of administration with dihexa? IN, IM, oral?



#569 VERITAS INCORRUPTUS

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Posted 22 April 2014 - 02:31 AM

what is the route of administration with dihexa? IN, IM, oral?

 

If I recall correctly, my interpretation was a derived estimated relative potency of injection being approximately 4-fold more potent than oral; therein placing oral bioavailability at a respectable ~25%, though the correlation is not exact.  I recall a dose given orally of 400% of that given via i.p. to foster significant improvement comparable to i.p., but in one model assay not to quite the degree of the comparative dose given i.p.  Hence my extrapolation was an oral bioavailability to likely require a  4-fold dose or slightly greater so as to confer an equitable effect.  

 

Obviously with most substances injection will confer superior potency, though such is surprising that a peptide (even a 'simple' tetrapeptide) maintains such a fair degree of oral bioavailability.  This was at the maximal dose assayed that showed significant effect.  From recall, said dosing was 2mg/kg p.o. in rats so the equitable oral dose for a 60kg animal would be approximately 20mg p.o. and 5mg i.m. - so research accordingly.


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#570 amara bin

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Posted 25 April 2014 - 12:09 PM

Pay via PayPal cjs2027@gmail.com
156 for us shipped
All non us 170 per gram

Sent






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