Posted 31 January 2013 - 09:57 AM
Your symptoms sound like low dopamine, maybe all catecholamines (dopamine, noradrenaline, adrenaline) in general to me.
You should be aware of what lowers catecholamines:
ssri's or any drugs, that increase serotonin
overtraining in the gym
abuse of drugs, stimulants, boosters that deplete catecholamines and/or their building blocks and cofactors
not having all building blocks and cofactors for your catecholamine production.
I guess there is more, but those are the most important factors.
Many won't believe me, lol, but when your catecholamine levels are high, there is no need for caffeine, training boosters, or drugs to feel energy and motivated.
You tried tyrosine, but you do not understand how catecholamine metabolism works, and I am pretty sure that this is why you felt just so little.
See, tyrosin gets converted to: l-dopa->dopamine->noradrenaline->adrenaline.
Each of these steps is not free, it needs enzymes, and cofactors to work.
for example, d3 increased tyrosine hydroxylase, the first step from tyrosine->l-dopa.
Other cofactors are:
calcium, folic acid, b12, b6, magnesium, iron, copper.
I would advise against taking copper and iron without medical supervision because those can fuck you up in the long run (oxidation, being made worse by some kinds of antioxidants btw).
So you see, you have to take all those together to get an effect. I am pretty sure that studies using tyrosine showed only that tyrosine was only effective for 4-6 weeks because the patients ran out of some cofactors. I managed to keep tyrosine working for a long time now (years), despite the studies, BUT it stopped working for me as soon as one cofactor was missing / too low. If only ONE cofactor is too low, the whole metabolism chain down the road after the cofactor is needed will be massively slowed down!!!
with d3 you can go a lot higher, like 30000iu/week, but I would recommend blood tests to get your d3 levels into the right range.
Now if you've been supplementing with b6, you may be zinc deficient since zinc is required for the conversion of b6 to the active form. So I would add zinc too.
See how you do on this combination, rather then tyrosine alone. Its like fueling a car with gas, but having no oil in the motor, and no battery to start the motor. One could then think "gas is useless" but that would be wrong as we all know.
The alternative would be to take dopamine agonists, if that does not work for you. One drawback is that this will only increase dopamine, but not (nor)adrenaline. That may be good or bad for you, depending on your starting point. As long as you have a lack of energy, you might not want that. Or, you could try l-dopa or mucuna, but be warned, its unhealty in the long run (esp. on the heart), and the effect is short term, while tyrosines effect is not only longer, but your body can choose where to convert it to catecholamines which is an important point to remember.
Also, have you been ingesting a lot of bromide? like... mountain dew etc. You could simply have an intoxication of bromide, or other stuff like lead, etc. In this case you could try high dose iodine, together with selenium. But here is a catch too:
Iodine will sensitize your receptors, which is a good thing. And it has so many positive effects on the body that I can not even list them all. But it is also a very potent detofixier of bromide, fluoride, lead and so on. And in high doses this can overwhelm your system because all those toxins will be released into your bloodstream and depending on the level of toxins in your body, your kidney may not be able to keep up with excreting them. There is a workaround though, called salt loading... I would suggest you research "orthoiodosupplementation" and read up how to properly use iodine for detoxification.
Also, I'd recommend you let your doc check your thyroid levels(prior to starting with iodine). Not only TSH, but also t4, t3. (and d3 levels, iron levels...)
its entirely possible to get your catecholamine levels back up.
If you have a family history of parkinson, however, this will be only half of the equation. You'll also have to do anything to increase neuroprotection and regeneration. What comes to mind here would be stuff like noopept, cerebrolysin, uridine. Again - if parkinson is the cause, you need both goals: increase catecholamines, increase neuroprotection/regeneration. Because believe me, if you do not act now, life will get a lot more shitty if you get parkinson.Especially because of this, you should get iron checked. If you have an overload, this will keep damaging your brain and fuck you up. All organs, actually.
I have been where you are now, looking at your symptoms. I was able to kick them out of my life. You can do it, too...
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