I only take NAC ( 600mg) the day after drinking alcohol to help replenish glutathione. It is also would do the same for anyone taking medications that deplete glutathione, like Tylenol .
Quote : " Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. Over two-thirds of 46 placebo-controlled clinical trials with orally administered NAC have indicated beneficial effects of NAC measured either as trial endpoints or as general measures of improvement in quality of life and well-being of the patients."
http://www.sciencedi...471489207000896
Regarding safety : Here is a in vivo study using intravenous NAC, 100 mg/kg in children with acute liver
failure
Quote : " In conclusion, the administration of NAC to children with ALF not caused by acetaminophen toxicity appeared to be safe and may be associated with a better outcome. The duration of hospital stay was shorter for children receiving NAC and they also appeared to have a higher incidence of native liver recovery and a better survival after LT. Our unit is currently participating in a prospective randomized controlled trial, hence continued use of NAC has been suspended."
Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure
" In conclusion, NAC is safe in non-acetaminophen-induced ALF. In this retrospective study NAC was associated with a shorter length of hospital stay, higher incidence of native liver recovery without transplantation, and better survival after transplantation. Liver Transpl, 2007. © 2007 AASLD."
http://onlinelibrary...2/lt.21246/full
Edited by Kevnzworld, 09 March 2013 - 05:59 AM.