LONGECITY

Has anyone investigated the use of Alpha-7 nicotinic receptor agonists/PAM's/partial agonists as nootropics? It's well known that nicoteine is used as a nootropic by some. Some more selective compounds specifically target the subunit that nicoteine targets with strong nootropic qualities. Wondering if anyone is interested? Some enhance the CREB pathway leading to increased concentrations of cAMP.

galantamine, donezepil are very impotrant nootropics

bdnf upregulate alpha 7 nicotinic receptors

where buy I injury with bdnf?

alpha 7 agonists downregulate d2, d3 or upregulate d2, d3?
Edited by warmin, 17 March 2013 - 05:13 PM.

galantamine, donezepil are very impotrant nootropics

bdnf upregulate alpha 7 nicotinic receptors

where buy I injury with bdnf?

alpha 7 agonists downregulate d2, d3 or upregulate d2, d3?

Yes, galantamine and donezepil are drugs used. They aren't specific enough to modulate alpa 7 nicotinic receptors. And I think they are agonists. Agonists aren't good. They eventually lead to desensitization of the receptor. Positive allosteric modulators are better at decreasing the threshold of receptor activation for example. alpha 7 agonists would modulate d2, d3 to my knowledge. I didn;t understand the part with bdnf... Thanks for posting. I think alpha 7 nicotinic receptors are interesting.

redan wrote..... alpha 7 agonists would modulate d2, d3 to my knowledge......

modulate-downregulate or upregulate?

bdnf injection upregulate alpha-7

redan wrote..... alpha 7 agonists would modulate d2, d3 to my knowledge......

modulate-downregulate or upregulate?

bdnf injection upregulate alpha-7

They would likely increasae the firing rate of D2, D1 neurons, methinks. They would be of interest to modulating dopamine firing. They also modulate NMDA.

I want lewamisole try

I think the working memory benefits come from agonizing the alpha 7 nicotinic receptors in the prefrontal cortex. I was wondering if anyone had reason to believe that bdnf would also increase alpha 7 receptors in the pfc. The study only showed increase receptors in hippocampal neurons.

I ask because I benefited cognitively from galantamine, but eventually got side effects from too much acetylcholine, and I have read that the alpha 7 receptors get desensitized very quickly.

So I was considering combining galantamine with a racetam, since I have read they lower acetylcholine (which is why they say to combine with choline) and they increase bdnf which could increase receptor density and stop desensitization...

Thoughts?

So I was considering combining galantamine with a racetam, since I have read they lower acetylcholine (which is why they say to combine with choline) and they increase bdnf which could increase receptor density and stop desensitization...

I think you should go back to the drawing board. Galantamine + Racetams doesn't sound like a bad combo, but your rationale as to why (racetams lowering acetylcholine so add choline) is not the really case with all racetams. Don't start building stacks based on half understood assumptions. Supplementing choline is not always required, and in the presence of Acetylcholinesterase Inhibitors, it can be a bad idea.
Edited by Jeoshua, 17 March 2014 - 12:37 PM.

memantine increase alpha-7 nicotinic receptors