Hi,
I'd like to discuss a safe and reliable method to use Selegiline long term without developing tolerance or withdrawal. I'm just going to dive right in in hopes of attracting other experienced Selegiline users and/or knowledgeable persons about the drug. Much of the Selegiline discussions on this board tend to end with no conclusions about the specific issue of tolerance.
First off, Selegiline raises dopamine levels in the brain. Most of us know this. Most of us also know that when levels are raised the receptors are then down regulated. Let me just stop for one second because I want to take this moment to briefly clarify that I am not as experienced or knowledgeable about how the brain works compared to many others on this message board. Far too many times have I been overwhelmed by the information many possess and I will not pretend to know what I'm talking about, but I know a little. Some of the tolerance from Selegiline is obviously from the down regulation of the receptors, so I'll start with that.
How can you avoid down regulating the receptors? Well, there are supplements that can help to upregulate them and that's probably pretty close to what you'd want. CDP-Choline is a big one along with Inositol. I'm sure there are others and maybe someone can shed more light on them. Anyway, if these supplements can upregulate the receptors, can't one just supplement with them occasionally to boost receptor densities?
Now, what about keeping receptors from down regulating faster? In the "great porn experiment" by Gary Wilson he discusses how porn can down regulate D2 receptors through visual stimulation paired with masturbation. This is already kind of controversial so I'd like to steer away from it. But really, we can achieve natural hits of dopamine from our own body through food, sex, and other activities that are rewarding. These must down regulate receptors as well, but probably not much. Even so, maybe it's possible to slow the down regulation of receptors by excluding anything else that might release high amounts of dopamine through supplementation or natural in-house activities. Off the top of my head that could include limiting caffeine, l-tyrosine, dlpa, porn, amphetamines, and maybe high calorie foods. This method I admit seems a little on the irrelevant side of things, but it's not hard to implement.
Now onto more complicated out-of-my league areas. Apparently there's this rumor that has been proven anecdotally 100's of times that NMDA receptor antagonists can slow down the tolerance build up to amphetamines. Selegiline isn't exactly an amphetamine, but it's been stated multiple times that it may as well be a very low dose of one. The mechanisms must at least be similar enough that NMDA receptor antagonists can still slow the tolerance build up. Memantine is the biggest one next to DXM for achieving this. Magnesium is also supposed to help but some say it's not nearly as useful as the others.
Ok so there's options to lengthening the time between re-cycling Selegiline and I hope I haven't totally turned the subject up on it's head with misinformation.
Please now allow me to share my methods and goals with this drug. I intend to use Selegiline at 5mg/weekly at 1mg/daily on weekdays with weekends off. I'll be dosing it in the evening sublingually after some fatty food for better absorption. I will then be using CDP-Choline at 250mg EOD indefinitely or until I become depressed. I might increase the dose after weeks of evaluation with no depression. I will also be supplementing with 500mg of Magnesium Citrate and 144mg of Magnesium Threonate daily.
Continuing.. I am a 23 year old male that exercises intensely 3-4 times a week. I eat well with many vegetables, fruits, and high quality protein. I get good sleep and I keep stress at bay. I also supplement with superfoods, vitamins, and minerals all from natural sources. I think I've built a good foundation for a normal healthy life. But now I want to take it a bit further with Selegiline.
I've reacted very well to this drug. It makes me more calm, more focused, less stressed, more joyful, more social, more motivated, less anxiety, better motor control... it's just been wonderful. I am hoping that at low doses and with the right accommodating supplements and lifestyle I can keep using it for 3-4 months with full benefits meaning no withdrawal or tolerance. Take a month off and then return for another 3-4 month cycle.
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So what do ya'll think? I'm more or less just trying to ensure that I am on a practical track with this drug. On another note, I have some unopened memantine that I kind of wanted to add but I'm not so sure anymore. Is it worthwhile? Or is magnesium good enough?
Edited by CrackaLackN, 22 March 2013 - 07:29 PM.