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Lostfalco's Extensive Nootropic Experiments [Curated]

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#3811 Judd Crane

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Posted 05 December 2017 - 02:17 PM

Hi Lostfalco,

 

Could you describe/illustrate the 9 regions you're putting the 96-LED on?

 

"5. 850nm, 96 LED, 9 individual "regions" on sides, top, and back of head AND 850nm, 48 LED, 5 individual spots on forehead along hairline (roughly)."



#3812 Olorin

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Posted 19 December 2017 - 12:04 PM

Hi,
 
have anyone looked at this study from S. Moskvin at the State Scientific Center of Laser Medicine in Moscow:
The title is "Only lasers can be used for low level laser therapy", and the conclusion is
"Thus, NON-laser light sources (lamps with or without filters, LEDs with or without a polarizer, etc.) cannot be used in low level laser therapy because of their minimal efficiency."
 
I have a vetrolaser, but for convenience I have been using LEDs instead. This makes me think it might be a good idea to go back to using the laser.
 

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#3813 bladedmind

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Posted 22 December 2017 - 08:52 AM

Dear Lostfalco:

 

Longtime lurker and fan, first time commenter.   I greatly admire your nootropic daring, and I'm glad you're busy with a great new job.  

 

I picked up LLLT and INI from you, thanks!

 

You said a few months ago, "Right now, I am testing every element of Dr. Bredesen's protocol simultaneously (with a few of my own additions)."    I'm an intellectual, but not educated in life sciences, 68 years old and APOE 4/4.  Thus, I'm very interested in your explorations and discoveries with the protocol.   Bredesen mentions a few substances in his book that are quite obscure and that remain unmentioned at apoe4.info.   Also, by the way, there is a an analytic elaboration of the Bredesen protocol at Anti-Aging Firewalls that might interest you.   http://www.anti-agin...art-1-the-plan/

 

Happy to hear your results someday. 

 

Best,

 

Bladedmind

 


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#3814 tms

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Posted 31 December 2017 - 10:53 AM

Hi everyone,

Are there people still using LLLT/TULIP ? I have a few questions. Hope I'm not polluting this thread. 


Edited by tms, 31 December 2017 - 10:55 AM.


#3815 lostfalco

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Posted 03 January 2018 - 02:33 AM

Hi everyone,

Are there people still using LLLT/TULIP ? I have a few questions. Hope I'm not polluting this thread. 

Hey tms, I'm still using it. =) 

 

What's up?



#3816 lostfalco

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Posted 03 January 2018 - 02:36 AM

Hi Lostfalco,

 

Could you describe/illustrate the 9 regions you're putting the 96-LED on?

 

"5. 850nm, 96 LED, 9 individual "regions" on sides, top, and back of head AND 850nm, 48 LED, 5 individual spots on forehead along hairline (roughly)."

Hey Judd, the main idea is to try to laser your entire brain. Don't get too caught up on the exact regions. I just found that I could get the front, back, and sides with about 9 non-overlapping placements of the 96 LED. 



#3817 lostfalco

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Posted 03 January 2018 - 03:11 AM

 

Hi,
 
have anyone looked at this study from S. Moskvin at the State Scientific Center of Laser Medicine in Moscow:
The title is "Only lasers can be used for low level laser therapy", and the conclusion is
"Thus, NON-laser light sources (lamps with or without filters, LEDs with or without a polarizer, etc.) cannot be used in low level laser therapy because of their minimal efficiency."
 
I have a vetrolaser, but for convenience I have been using LEDs instead. This makes me think it might be a good idea to go back to using the laser.

 

Hey Olorin, this is a very strange, emotional article (ie. not very scientific). I wouldn't let it sway your decision of which device to use. This was a hotly debated topic 20 years ago but the majority of LLLT practitioners now think that LEDs are just effective as lasers for one reason: LEDs work in experiments. 

 

Here are a few recent examples. =)

 

https://www.ncbi.nlm...pubmed/28464523

J Biophotonics. 2017 Dec;10(12):1761-1771. doi: 10.1002/jbio.201700038. Epub 2017 May 2.

Low-level light emitting diode therapy promotes long-term functional recovery after experimental stroke in mice.

Lee HI1,2Lee SW3,4,5Kim NG6Park KJ6Choi BT3,4,5Shin YI1,2Shin HK3,4,5.
Abstract

We aimed to investigate the effects of low-level light emitting diode therapy (LED-T) on the long-term functional outcomes after cerebral ischemia, and the optimal timing of LED-T initiation for achieving suitable functional recovery. Focal cerebral ischemia was induced in mice via photothrombosis. These mice were assigned to a sham-operated (control), ischemic (vehicle), or LED-T group [initiation immediately (acute), 4 days (subacute) or 10 days (delayed) after ischemia, followed by once-daily treatment for 7 days]. Behavioral outcomes were assessed 21 and 28 days post-ischemia, and histopathological analysis was performed 28 days post-ischemia. The acute and subacute LED-T groups showed a significant improvement in motor function up to 28 days post-ischemia, although no brain atrophy recovery was noted. We observed proliferating cells (BrdU+ ) in the ischemic brain, and significant increases in BrdU+ /GFAP+ , BrdU+ /DCX+ , BrdU+ /NeuN+ , and CD31+ cells in the subacute LED-T group. However, the BrdU+ /Iba-1+ cell count was reduced in the subacute LED-T group. Furthermore, the brain-derived neurotrophic factor (BDNF) was significantly upregulated in the subacute LED-T group. We concluded that LED-T administered during the subacute stage had a positive impact on the long-term functional outcome, probably via neuron and astrocyte proliferation, blood vessel reconstruction, and increased BDNF expression. Picture: The rotarod test for motor coordination showed that acute and subacute LED-T improves long-term functional recovery after cerebral ischemia.

 

https://www.ncbi.nlm...pubmed/28347821

Biochem Biophys Res Commun. 2017 May 13;486(4):945-950. doi: 10.1016/j.bbrc.2017.03.131. Epub 2017 Mar 24.
Pretreatment with light-emitting diode therapy reduces ischemic brain injury in mice through endothelial nitric oxide synthase-dependent mechanisms.
Abstract

Photostimulation with low-level light emitting diode therapy (LED-T) modulates neurological and psychological functions. The purpose of this study was to evaluate the effects of LED-T pretreatment on the mouse brain after ischemia/reperfusion and to investigate the underlying mechanisms. Ischemia/reperfusion brain injury was induced by middle cerebral artery occlusion. The mice received LED-T twice a day for 2 days prior to cerebral ischemia. After reperfusion, the LED-T group showed significantly smaller infarct and edema volumes, fewer behavioral deficits compared to injured mice that did not receive LED-T and significantly higher cerebral blood flow compared to the vehicle group. We observed lower levels of endothelial nitric oxide synthase (eNOS) phosphorylation in the injured mouse brains, but significantly higher eNOS phosphorylation in LED-T-pretreated mice. The enhanced phospho-eNOS was inhibited by LY294002, indicating that the effects of LED-T on the ischemic brain could be attributed to the upregulation of eNOS phosphorylation through the phosphoinositide 3-kinase (PI3K)/Akt pathway. Moreover, no reductions in infarct or edema volume were observed in LED-T-pretreated eNOS-deficient (eNOS-/-) mice. Collectively, we found that pretreatment with LED-T reduced the amount of ischemia-induced brain damage. Importantly, we revealed that these effects were mediated by the stimulation of eNOS phosphorylation via the PI3K/Akt pathway.

 

https://www.ncbi.nlm...pubmed/28001756

Photomed Laser Surg. 2016 Dec;34(12):610-626. doi: 10.1089/pho.2015.4037.
Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to Improve Cognition in Chronic Traumatic Brain Injury.
Naeser MA1,2Martin PI1,2Ho MD1,2Krengel MH1,2Bogdanova Y1,3Knight JA1,3,4Yee MK1,2Zafonte R5,6,7,8Frazier J9Hamblin MR10,11,12Koo BB13.
Abstract

We review the general topic of traumatic brain injury (TBI) and our research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. tPBM improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is released from the cells increasing regional blood flow in the brain. Review of published studies: In our previously published study, 11 chronic TBI patients with closed-head TBI caused by different accidents (motor vehicle accident, sports-related, improvised explosive device blast injury) and exhibiting long-lasting cognitive dysfunction received 18 outpatient treatments (Monday, Wednesday, Friday for 6 weeks) starting at 10 months to 8 years post-TBI. LED therapy is nonthermal, painless, and noninvasive. An LED-based device classified as nonsignificant risk (FDA cleared) was used. Each LED cluster head (5.35 cm diameter, 500 mW, 22.2 mW/cm2) was applied for 9 min 45 sec (13 J/cm2) using 11 locations on the scalp: midline from front-to-back hairline and bilaterally on frontal, parietal, and temporal areas. Testing was performed before and after transcranial LED (tLED; at 1 week, 1 month, and at 2 months after the 18th treatment) and showed significant improvements in executive function and verbal memory. There were also fewer post-traumatic stress disorder (PTSD) symptoms reported. Ongoing studies: Ongoing, current studies involve TBI patients who have been treated with tLED using either 26 J/cm2 per LED location on the head or treated with intranasal only (iLED) using red (633 nm) and NIR (810 nm) diodes placed into the nostrils. The NIR iLED is hypothesized to deliver photons to the hippocampus, and the red 633 nm iLED is believed to increase melatonin. Results have been similar to the previously published tLED study. Actigraphy sleep data showed increased time asleep (on average one additional hour per night) after the 18th tLED or iLED treatment. LED treatments may be performed in the home. Sham-controlled studies with veterans who have cognitive dysfunction from Gulf War Illness, blast TBI, and TBI/PTSD are currently ongoing.

 

 

 


Edited by lostfalco, 03 January 2018 - 03:13 AM.

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#3818 lostfalco

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Posted 03 January 2018 - 03:17 AM

Dear Lostfalco:

 

Longtime lurker and fan, first time commenter.   I greatly admire your nootropic daring, and I'm glad you're busy with a great new job.  

 

I picked up LLLT and INI from you, thanks!

 

You said a few months ago, "Right now, I am testing every element of Dr. Bredesen's protocol simultaneously (with a few of my own additions)."    I'm an intellectual, but not educated in life sciences, 68 years old and APOE 4/4.  Thus, I'm very interested in your explorations and discoveries with the protocol.   Bredesen mentions a few substances in his book that are quite obscure and that remain unmentioned at apoe4.info.   Also, by the way, there is a an analytic elaboration of the Bredesen protocol at Anti-Aging Firewalls that might interest you.   http://www.anti-agin...art-1-the-plan/

 

Happy to hear your results someday. 

 

Best,

 

Bladedmind

Hey Bladedmind, thanks so much! I'm glad you've gained something from some of my experiments. 

 

I'm still testing everything from Bredesen's protocol. I'll be sharing one of these days (hopefully soon). 

 

Thanks for the link. I like Vince's site so I'll definitely have to check it out. 


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#3819 Mr. Olive Oil

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Posted 04 January 2018 - 01:35 PM

Hi Lostfalco,

 

I was wondering if LLLT on mice possibly has a better effect because of how small their skulls are?

 

It seems the light can penetrate at least one inch into the human brain. Wouldn't the light be able to penetrate the entire brain of mice?

Apologies if this question was asked before!
Thank you either way.



#3820 airplanepeanuts

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Posted 05 January 2018 - 10:41 PM

I am contemplating to buy a joovv device to use on my head because it scares me to use a device intended for a completely different purpose. Do you guys think this is wasted money?



#3821 lostfalco

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Posted 06 January 2018 - 01:30 AM

I am contemplating to buy a joovv device to use on my head because it scares me to use a device intended for a completely different purpose. Do you guys think this is wasted money?

The cheapest one I saw was $495! 

 

I'd test out a $20 device first before spending that much. 


Hi Lostfalco,

 

I was wondering if LLLT on mice possibly has a better effect because of how small their skulls are?

 

It seems the light can penetrate at least one inch into the human brain. Wouldn't the light be able to penetrate the entire brain of mice?

Apologies if this question was asked before!
Thank you either way.

Their skulls are definitely thinner than ours which is why dosing is adjusted for humans. 

 

Here are affordable devices to try out and how to calculate dosing for humans. http://www.lostfalco...therapy-dosing/


Edited by lostfalco, 06 January 2018 - 01:34 AM.


#3822 lostfalco

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Posted 09 January 2018 - 05:50 PM

Enjoy!

 

https://www.ncbi.nlm...pubmed/29307593

 

Brain Res. 2018 Jan 4. pii: S0006-8993(17)30582-6. doi: 10.1016/j.brainres.2017.12.040. [Epub ahead of print]
Transcranial near-infrared photobiomodulation attenuates memory impairment and hippocampal oxidative stress in sleep-deprived mice.
Abstract

Sleep deprivation (SD) causes oxidative stress in the hippocampus and subsequent memory impairment. In this study, the effect of near-infrared (NIR) photobiomodulation (PBM) on learning and memory impairment induced by acute SD was investigated. The mice were subjected to an acute SD protocol for 72 hr. Simultaneously, NIR PBM using a laser at 810 nm was delivered (once a day for 3 days) transcranially to the head to affect the entire brain of mice. The Barnes maze and the What-Where-Which task were used to assess spatial and episodic-like memories. The hippocampal levels of antioxidant enzymes and oxidative stress biomarkers were evaluated. The results showed that NIR PBM prevented cognitive impairment induced by SD. Moreover, NIR PBM therapy enhanced the antioxidant status and increased mitochondrial activity in the hippocampus of SD mice. Our findings revealed that hippocampus-related mitochondrial damage and extensive oxidative stress contribute to the occurrence of memory impairment. In contrast, NIR PBM reduced hippocampal oxidative damage, supporting the ability of 810 nm laser light to improve the antioxidant defense system and maintain mitochondrial survival. This confirms that non-invasive transcranial NIR PBM therapy ameliorates hippocampal dysfunction, which is reflected in enhanced memory function.

 



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#3823 Mr. Olive Oil

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Posted 13 January 2018 - 09:47 AM

Hi Lostfalco,

 

I was wondering if LLLT on mice possibly has a better effect because of how small their skulls are?

 

It seems the light can penetrate at least one inch into the human brain. Wouldn't the light be able to penetrate the entire brain of mice?

Apologies if this question was asked before!
Thank you either way.

Their skulls are definitely thinner than ours which is why dosing is adjusted for humans. 

 

Here are affordable devices to try out and how to calculate dosing for humans. http://www.lostfalco...therapy-dosing/

 

 

Thank you for the reply and the link. I read it but I think I am still misunderstanding or I worded my previous post badly-

 

Since mice brains are so small, and the light can fully penetrate throughout (reaching every part and the hippocampus completely), how would dosing adjustments for humans compensate?

Considering the light penetrates one inch into the human brain, I assume that we have a limitation in effect compared to the full light penetration with mice?

 

P.S:

I have been using the 10,000 lux sunbright product each morning for eye exposure and it has made me feel more alert, energetic, and most important of all... it boosts my mood!

 

Edit: Not sure if chitosan has been discussed in this thread, but I am going to start researching it tomorrow. Seems it increases intranasal administration through the olfactory nerve tissue and is effective with NGF. I wonder if it can be added into insulin without compromising the solution.

 

https://www.ncbi.nlm...pubmed/19156912

https://www.ncbi.nlm...pubmed/21879386
 


Edited by highlightfocus, 13 January 2018 - 09:51 AM.






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