9 replies to this topic

[BioFreak]

Well the topic says it. I am a non responder / high side effects responder from chronic noopept use. However, I got a massive boost when using n-acetyl-cysteine not low dose (like 900mg/day split in 3) but HIGH dose (aprox 3g/day split in 3).

Now this is the opposite of noopepts side effects what I experienced with high dose nac and I wondered if anyone tried that combination yet who did not respond well to chronic noopept alone?

I would try it myself, but I need to be very productive at the moment, so I won't test it for some time.

[DamnedOwl]

Interesting.

I take NAC most days at a single dose of 1000mg, which I do in the hope that any alcohol I drink will be less harmful to me, but I'd long suspected for a while now that it was having something of an amplifying effect on some of the more nootropic (or nootropic-like) substances I take like piracetam and modafinil.

[BLimitless]

N-Acetyl-Cysteine (6-15g, 1tbsp) + Vit C (3g) makes me feel amazing no matter the occasion. And it gives a clear vigour to all other substances in the system. Definitely potentiates other nootropics and has many of its own to boot.

A lot of things can be taken in higher doses than typically used, as they are practically just nutrients and less is not always more when it comes to these things.

This combo works wonders on any kind of stress-induced fatigue on the body. Combine it with a heavy green smoothie based on broccoli, kale and spinach (300g altogether) and you will find your fatigue, wearyness and tiredness just dissolve like they've been watered away.

Edited by BLimitless, 14 May 2013 - 03:52 PM.

[DamnedOwl]

Even in a smoothie, surely that much NAC must be a real challenge to swallow? I'm fairly hardy when it comes to these things but I find even my 1g dose dissolved in about a 3/4 pint of water to be a tad unpleasant.

Still, I'm nevertheless interested to see whether upping my dose will bring similarly pronounced effects.

How often to you do this? Every day? Occasionally?

[BioFreak]

Wow, 6-15g... thats a LOT. Still worring about side effects at chronic higher dosages (above 10g?) like the ones rats had.

For the taste I mix nac with sodium bicarbonate, its better for the teeth too. Should not make any difference in the body, at least I still feel the effects.

NAC in high dosages is somewhat of a game changer for me.

[BLimitless]

Yes I do not do chronic high doses. If I dose 15g it will be once in a while on a very stressful day. However I dose regularly at 3-6g with zero issues. It's one of those things that actually feels very good to put into your body altogether though yet I do not know what dose would start doing more harm than good.


I drink my NAC with water, rarely some kind of juice or smoothie. I am used to things tasting funky, things of all kinds. NAC is like a really zingy sherbet powder more so than anything. Now if you had tasted a couple of the various roots I have savoured over the last few years, you might gleam a certain kind of appreciation for such flavours that are strong but thankfully do not immediately trigger instantaneous projectile vomiting, spontaneous combustion and enlightened euphoria.


No comment on what it can do to the teeth. I don't know, should I be worried? It feels a tiny bit acidic but I have never noticed any changes in tooth sensitivity or any strange signals from my teeth after drinking NAC.


What I can say is that Coconut oil seems to have a very similar effect on the brain, though acting via very different mechanisms. Both coconut and NAC produce a crystal clearheadedness & sharpness with corresponding relaxation of the eyes. In fact I learnt off another member here that coconut oil reverses the brain fog induced by Piracetam, which immediately I put into trial by administering a nice coconut oil shake to find it working wonders. I do believe it would work for Noopept and potentiate Noopept too. Unlike NAC there is no real worry about dosing this high as it is a macronutrient.

I will have to test out the actual combo of Pept and NAC as described, I do not have any systematic observations of the difference between Pept alone vs Pept + high dose NAC. Never really thought about it until you pointed it out actually.

[DamnedOwl]

Well, I took a double dose (2g) yesterday evening, and after having felt less than optimal all day, I began to feel far more of a balanced state. So this higher-dose NAC's certainly something I'll be giving more attention to.

I've always taken NAC between 6 and 7pm before, so I'll be interested to see how I fare with it when I take it in the morning, and also if I can distinguish any effects between the varying doses.

I must look over again any of the safety concerns associated with NAC though. I remember concluding that at 1g most days it was safe, but about these much higher doses I just don't know.

By the way, I'd always taken NAC on empty stomach - how about you guys?

[DamnedOwl]

And in what form do you take the coconut oil? Since you put it in a shake, I assume it was the powdered/liquid form rather than the softgels. What kind of quantities are you taking?

[cATsE]

N-Acetyl-Cysteine (6-15g, 1tbsp)

That's a total waste, IMO. The stuff will be out of your body in a matter of hours. Better invest in a time-release form of N-A-C (Jarrow comes to mind) and take that like 3-4 times a day. That way you don't have to take so much, it doesn't taste like crap AND it will have more effect too.

[edit] Just looked it up, plain N-A-C has a biological half-life of 1 1/2 hour!

Edited by cATsE, 15 May 2013 - 11:06 AM.

[BioFreak]

Well if your teeth get in contact with a lot of acid, chronically, they will have a hard time. So its probably best to neutralize acids or weaken them.

BLimitless, do you normally have side effects with noopept, or no benefits? Or do you want to see if it improves noopepts effects for you further?

I did not bother to take it on an empty stomach only.

Maybe it's not nac that is needed for long time effects. I.e.:
upregulation of genes that stay that way for some time
effects from substances that need nac as building block (glutathione, ...)

Also, its half life is how long you can detect it in blood, I think. That means any substance that gets readily absorbed into cells would not show up for long, but still have a benefit for longer times then its half life would suggest. For example, this makes sense for any precursors, while half life is important for any substance that acts on cell receptors (like hormones) - if its no longer in the blood, it can't act on receptors in the body.

etc...

Just from my personal experience, 3x1g/day did not lead to a benefit intensitiy curve of 1 1/2 hours, it is present the whole day.

Edited by BioFreak, 15 May 2013 - 03:12 PM.