10 replies to this topic

[platypus]

What would you include in a stack whose purpose was to delay the onset of Alzheimer's in the elderly? There are too many things out there that might help, what would you do? I was thinking about the following:

- High dose curcumin
- Green tea extract
- Fish oil, olive oil and coconut oil
- A good multi with enough B-vitamins

What else?

[tunt01]

Don't think I would use "high dose" curcumin per se, given that it has been shown to reduce lifespan in mice (w/o statistical significance). I would use it in conjunction w/ vitamin D.

I think exercise, proper nutrition (multi-vitamin is OK, but somewhat of a crutch), and well spaced meals w/ no snacking is critical.

I would probably add carnosine.

[Turnbuckle]

Niacinamide.

These preclinical findings suggest that oral nicotinamide may represent a safe treatment for AD and other tauopathies, and that phosphorylation of tau at Thr231 may regulate tau stability.

[renfr]

Yearly IP6 chelation to reduce iron stores (unless your ferritin is low), iron causes ROS damage and accumulation damages the brain.
http://www.ncbi.nlm....ubmed/15105269/

[ta5]

Don't think I would use "high dose" curcumin per se, given that it has been shown to reduce lifespan in mice (w/o statistical significance).

Which study was that?

This review references studies that showed increase lifespan in mice, fruit flies, and roundworm:



Biofactors. 2013 Jan-Feb
Curcumin and aging.
Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
Turmeric has been used commonly as a spice, food additive, and an herbal medicine worldwide. Known as a bioactive polyphenolic extract of Turmeric, curcumin has a broad range of health benefit properties for humans. Recently, active research on curcumin with respect to aging and related traits in model organisms has demonstrated that curcumin and its metabolite, tetrahydrocurcumin (THC), increase mean lifespan of at least three model organisms: nematode roundworm, fruit fly Drosophila, and mouse. Nematodes grown on media containing curcumin showed a significantly increased lifespan by reducing the production of reactive oxygen species. Genes osr-1, sek-1, mek-1, skn-1, unc-43, sir-2.1, and age-1 are required for curcumin-mediated lifespan extension. The lifespan extension of Drosophila by curcumin supplementation was associated with increased superoxide dismutase (SOD) activity, and decreased lipofuscin and malondialdehyde levels. Curcumin up-regulated expression of SOD genes and down-regulated expression of several age-related genes, such as dInR, ATTD, Def, CecB, and DptB. In addition, THC extended lifespan in Drosophila and inhibited the oxidative stress response by regulating FOXO and Sir2. Mice fed diets containing THC starting at the age of 13 months had significantly increased mean lifespan. In summary, the positive effects of curcumin on lifespan extension likely arise from beneficial regulation of common oxidative stress responses and age-related genes. Understanding the molecular mechanism(s) of curcumin action has provided base knowledge and rationale for future human clinical trials, and for nutritional intervention in aging and age-associated disorders in humans.
PMID: 23325575

[Logic]

PQQ http://en.wikipedia....inoline_quinone

[tunt01]

Which study was that?

http://online.lieber...9/rej.2012.1386

I trust in Dr. Spindler's work.

Attached Files

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[Rich D]

Cinnamon
http://www.forbes.co...mins-and-spice/

[tunt01]

Interestingly there was another paper in that same issue of Rejuvenation Research stating that ginger extract was a good intervention.

http://www.ncbi.nlm....pubmed/23374025

[mait]

Coconut oli added to daily diet. And supplementing with Ashwagandha (Withania somnifera).

Ashwagandha because of:
http://www.ncbi.nlm....pubmed/20680931
http://www.pnas.org/...109/9/3510.full
http://www.degruyter...8FB856BFBC0375A
http://www.ergo-log....alzheimers.html

I am also for curcumin (because of Fe chelation) and for vitamin C (a copper chelator).
http://www.ncbi.nlm....0?dopt=Abstract

Edited by mait, 25 May 2013 - 05:59 PM.

[Logic]

Mr Happy's Uridine, Choline, DHA stack?