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Alagebrium/ALT-711 Suppliers

algebrium alt-711 supplement supplier

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#1 solarfingers

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Posted 08 June 2013 - 03:18 PM


I performed a search and located the following vendors selling Alagebrium/ALT-711...

Has anyone bought Algebrium/ALT-711 from or had any business with any of these vendors? If so, what was your experience?

http://www.iron-dragon.com
ALT-711 (thiazolium chloride), 15g $67.00

http://www.greatwhitepeptides.com
ALT-711 (15MG PER 1ML 60ML BOTTLE W MARKED MEASURING DEVICE) $79.99

http://www.stenlabs.com
ALT-711 (thiazolium chloride), 15 mg/ml x 30ml - 450mg total- [AT11] Sale $29.99

http://www.topracehorse.com
ALT711 25mg X 30ml $69.99

http://www.spectrumpeptides.com
ALT-711 25mg X 30ml $69.99

Thanks!

#2 Logic

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Posted 08 June 2013 - 11:12 PM

Local posts mentioning these:

iron dragon:
http://www.longecity...pryl-emsam-etc/
http://www.longecity...bowel-movement/
http://www.longecity...4-pramiracetam/
http://www.longecity...am/page__st__30

Greatwhitepeptides:

Sten Labs:
http://www.longecity...bowel-movement/
http://www.longecity...gebriumalt-711/
http://www.longecity...aminoguanidine/

topracehorse:

spectrumpeptides:


Based on this it looks like Iron Dragon is the way to go?

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#3 solarfingers

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Posted 09 June 2013 - 04:06 AM

Local posts mentioning these:

iron dragon:
http://www.longecity...pryl-emsam-etc/
http://www.longecity...bowel-movement/
http://www.longecity...4-pramiracetam/
http://www.longecity...am/page__st__30

Greatwhitepeptides:

Sten Labs:
http://www.longecity...bowel-movement/
http://www.longecity...gebriumalt-711/
http://www.longecity...aminoguanidine/

topracehorse:

spectrumpeptides:


Based on this it looks like Iron Dragon is the way to go?


I'll have to look them up and see how long this site has been up... It would be nice to hear from some people who are taking it. Some people just like to protect their sources...

#4 zen

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Posted 09 June 2013 - 03:29 PM

If I am not mistaken it looks like the Iron Dragon website sells Alagebrium in the powder form while the rest on the websites mentioned by solarfingers sells some kind of Alagebrium solutions. Do you know what is used to dissolve Alagebrium and create solution? Is it necessary to dissolve Alagebrium before consuming it?

Edited by zen, 09 June 2013 - 03:30 PM.


#5 zen

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Posted 09 June 2013 - 03:36 PM

Local posts mentioning these:

iron dragon:
http://www.longecity...pryl-emsam-etc/
http://www.longecity...bowel-movement/
http://www.longecity...4-pramiracetam/
http://www.longecity...am/page__st__30

Greatwhitepeptides:

Sten Labs:
http://www.longecity...bowel-movement/
http://www.longecity...gebriumalt-711/
http://www.longecity...aminoguanidine/

topracehorse:

spectrumpeptides:


Based on this it looks like Iron Dragon is the way to go?



The most cost effective way seems to be to order directly from China, Alibaba website lists one supplier who has min order 100g with the price $2-$3 per gram http://www.alibaba.c...Text=alagebrium

#6 solarfingers

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Posted 09 June 2013 - 03:44 PM

The most cost effective way seems to be to order directly from China, Alibaba website lists one supplier who has min order 100g with the price $2-$3 per gram http://www.alibaba.c...Text=alagebrium


Granted, and this is what vendors like these are doing... Buying from China and selling it to consumers in lesser quantities. Markup is likely twice their cost. On the other hand this is a service for people who don't want to spend $200 - $300 dollars upfront to use a supplement. It would be interesting to start a supplemental coop to reduce the cost.

I'm not sure if it is water soluble or not.

Edited by solarfingers, 09 June 2013 - 03:45 PM.


#7 Logic

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Posted 09 June 2013 - 03:56 PM

To summarise; Iron Dragon seems ok and pretty well trusted by forum members, whereas the stuff that Sten Labs sells as ALT-711 isn't.

The other companies are not mentioned on this forum.
The other place to get ALT-711 is from MoreLife:
http://morelife.org/...ms/ALT-711.html
You will however have to write an SA explain that you are not an agent for whoever has the patent on ALT-711 and that you are worthy of ALT-711. With references!

Given the info on kidney rejuvenation, by Poolboy, I'm surprised there isn't more interest in this stuff!?
http://www.longecity...post__p__505800

#8 solarfingers

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Posted 09 June 2013 - 04:19 PM

Eroids review's of Iron Dragon

Review on RXMuscle.com

Whois reveals that the company is six years old. Generally if a company survives it's 5 year mark it is on its way to becoming establised. Domain: irondragon.com Owner: Registrant obfuscated Description: http://www.irondragon.com Registrar: GODADDY.COM, LLC Creation Date: 02-jan-2004 Expiration Date: 2014-01-02 Status: taken Last Updated: 28-dec-2012 Name server: NS19.DOMAINCONTROL.COM, NS20.DOMAINCONTROL.COM

#9 blood

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Posted 10 June 2013 - 08:52 AM

http://www.iron-dragon.com
ALT-711 (thiazolium chloride), 15g $67.00


15 gram wouldn't last long at a daily dose of 300 mg.

#10 niner

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Posted 10 June 2013 - 12:49 PM

If I am not mistaken it looks like the Iron Dragon website sells Alagebrium in the powder form while the rest on the websites mentioned by solarfingers sells some kind of Alagebrium solutions. Do you know what is used to dissolve Alagebrium and create solution? Is it necessary to dissolve Alagebrium before consuming it?


I would never buy a compound like this in solution. That's a ticket to watch your drug decompose at a vastly increased rate. Alagebrium is relatively small and charged- it looks water soluble to me. Buy the powder and cap it.
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#11 solarfingers

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Posted 10 June 2013 - 02:08 PM

http://www.iron-dragon.com
ALT-711 (thiazolium chloride), 15g $67.00


15 gram wouldn't last long at a daily dose of 300 mg.


Well is it depends on how much you need. This looks like the kind of thing you want to reverse damage and use less costly preventative supplements to follow-up like Aminoguanidine and L-Carnosine. You might to want to use it for 30 days and wait another 6 months to a year before using it again.

It depends on what you can afford... I would do something like take ALT-711 once a year for a month, Aminoguandine every six months for two months and L-Carnosine daily for a year...

You are ramping up to this 1mg/kg of ALT-711 level?

::Yes. Based on the fact that human metabolism is not that different from dogs in size and rate. Other abstracts also suggest that is a good dosage to aim for. I am 63-64 kg and Kitty is 54-55 kg and we mix our powders together for simplicity, so I decided to aim for a 60 mg daily dosage average with her taking a little less of the mix than I do.::

In the same article, another studys results are described (and the dosage was 10mg/kg every other day)

Studies on the effects of ALT-711 on healthy older rhesus monkeys showed that an injection of 10 mg/kg ALT-711, every other day for three weeks, improved the flexibility of all vessel walls, increased blood flow to the heart and enhanced blood delivery from the left ventricle into circulation. The improved vascular flexibility persisted over time, with maximum improvement seen six weeks after the end of ALT-711 treatment, and a gradual return to baseline 39 weeks after treatment was stopped. Improvement in cardiac functions persisted longer, continuing until the end of the study, at 39 weeks.

::I am always cautious with new supplements, especially xenobiotics, so I decided to start with the smaller dose. If you took the larger dose, it would be a lot more expensive, but you might be able to save by cycling off and on as in that experiment. Based the way ALT-711 operates, one could make a case for either methods. For myself it is far easier to take a regimen constantly than to cycle on and off. I make enough changes with new products and formulations constantly changing that I dont need any additional self-enforced ones to remember. What the larger dose does show however, is that this chemical is quite safe and tolerable, and is likely to be even moreso at the smaller dosage..::

Later on in the same article, another studys postive results are summarized (dosage level 210mg/day)

In the studies, that you know of, conducted on ALT-711, which dosage levels are associated with positive (and I realize that positive is extremely vague) results?

Thanks,

Stephen Flynn


In a trial of 93 humans, aged >= 50 years and with evidence of vascular stiffening, given an oral dosage of 210 mg of ALT-711 daily for 56 days...

Thanks...

Edited by solarfingers, 10 June 2013 - 02:54 PM.

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#12 Logic

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Posted 10 June 2013 - 03:52 PM

I wonder about synergies between ALT-711, aminoguanidine, chelators such as EDTA etc. and plant based AGE breakers (tetrahydrostilbene's etc.) and the other known breakers and blockers?

Has anyone else considered this and done any research?

#13 zen

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Posted 11 June 2013 - 12:16 AM

I would never buy a compound like this in solution. That's a ticket to watch your drug decompose at a vastly increased rate. Alagebrium is relatively small and charged- it looks water soluble to me. Buy the powder and cap it.

Thank you for your advice! If I decide to give it a try I will definitely buy the powder and not the solution.

#14 blood

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Posted 12 June 2013 - 06:30 AM

Well is it depends on how much you need. This looks like the kind of thing you want to reverse damage and use less costly preventative supplements to follow-up like Aminoguanidine and L-Carnosine. You might to want to use it for 30 days and wait another 6 months to a year before using it again.

It depends on what you can afford... I would do something like take ALT-711 once a year for a month, Aminoguandine every six months for two months and L-Carnosine daily for a year...



What are your thoughts on benfotiamine?

http://benfotiamine....nfo600Study.pdf



Here, we studied the effect of benfotiamine, a lipid-soluble thiamine
derivative with known AGE-inhibiting properties in-vitro on the
intracellular formation of (CML) and methylglyoxal-derived AGE in
red blood cells. Blood was collected from 6 Type 1 diabetic patients
(2 m, 4 f, age 31.8 ± 5.5 years; diabetes duration 15.3 ± 7.0 years)
before and after treatment with 600 mg/day benfotiamin for 28 days.

In addition to HbA1c (HPLC), CML and methylglyoxal were
measured using specific antibodies and a quantitative dot blot
technique

While treatment with benfotiamin did not affect HbA1c levels (at
entry: 7.18±0.86%; at conclusion 6.88±0.88%; p not significant),
levels of CML decreased by 40% (737 ± 51 arbitray unit/mg protein
(AU) vs 470 ± 86 AU; p<0.001). The levels of intracellular
methylglyoxal-derived AGE were reduced by almost 70% (1628 ±
1136 AU vs 500 ± 343 AU; p < 0.01). The data indicate that thiamine
derivatives are effective inhibitors of both intracellular glycoxidation
and AGE formation.


Edited by blood, 12 June 2013 - 06:32 AM.


#15 solarfingers

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Posted 12 June 2013 - 02:10 PM

Benfotiamine sounds like a useful product. I do believe there was some concern about it activating cancer. I think that's why I discounted it. I probably should spend more time looking at it since my bias about cancer seems to have waned on other products.

#16 solarfingers

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Posted 12 June 2013 - 06:39 PM

I recant...

What I have heard about Benfotiamine's connection to cancer:

Note From Benfotiamine.Org:

A knowledgeable benfotiamine user has offered the following response to this article:

"I have searched through the publications of Laszlo Boros on the connection between thiamine and cancer and can report that he has developed so far no evidence that there is a link in humans. In laboratory rats, however, he showed that if they were initially deficient in thiamine, then thiamine supplementation improved the growth of advanced tumors, which are typically thiamine deficient. There was no evidence that thiamine supplementation encouraged the initial appearance of tumors or the increased growth of non-advanced tumors. Interestingly, extremely high megadoses of thiamine were found to have the opposite effect, reducing the growth of advanced tumors."

http://www.longecity...ncer-risk-quit/
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#17 zorba990

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Posted 22 June 2013 - 08:20 PM

How much Alagebrium would one add to 2oz (about 50 grams) of lotIon for topical use?

#18 solarfingers

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Posted 22 June 2013 - 09:16 PM

Sorry, I have no idea. Perhaps somebody else has tried this...

#19 Logic

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Posted 23 June 2013 - 12:23 PM

How much Alagebrium would one add to 2oz (about 50 grams) of lotIon for topical use?


https://www.google.c...iw=1242&bih=504

#20 JohnFurber

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Posted 27 April 2014 - 02:47 AM

Would you really trust a Chinese source?  How would you know what you were getting? How would you test it's purity? How could you get your money back if they send you sugar?

OK. For starters, the pure alagebrium is absolutely sparkling, crystalline white, like freshly fallen snow.  Any hint of grey, yellow, or brown is impurity.

Second, it is highly soluble in water, and also absorbs moisture from the air.  You can set a spoonful on the scale and watch it get heavier by the second as it absorbs moisture from the air.  So you want to keep it stored in an airtight bottle with a silica gel packet.  Store it in the dark, not in direct sunlight.  For long term storage, you can freeze it for years, but let it come to room temp before opening the jar, to avoid condensation.

If you want drops, you can easily mix 100 mg/mL, or even 200 mg/mL in distilled water (water from the Glacier RO machine works fine) or even vodka. It is more stable in distilled water than in vodka.  But it is much more stable as a dry solid, kept in the dark.

To test composition, you can do a melting point test. It melts very sharply at around 219-221C with decomposition to a brown or black substance.  If you see a broad melting range, it is not pure. Because of the decomposition, you need to raise the temperature rapidly so that you will see the melting before it decomposes.

You could also have more expensive tests done (HPLC, Mass Spec) if you are buying a large quantity.

The taste is extremely bitter!  Even with a dropperful of 100 mg/mL solution, you would want to dilute it in a glass of water or grapefruit juice.  Or else make capsules.

You can find some background info here:

http://LegendaryPhar.../glycation.html

I know several people who have taken 100 mg/day of pure alagebrium for 14 years.

I hope this helps.


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#21 niner

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Posted 28 April 2014 - 12:26 PM

I know several people who have taken 100 mg/day of pure alagebrium for 14 years.


John, thanks for that fantastic information about alagebrium purity and handling! I'm curious about the long term users- What have their experiences been? Do they notice any improvements, for example in skin suppleness/elasticity? FMD? I assume these people are not diabetic. Do you think there's a chance of a glucosepane breaker anytime soon?

#22 Golestan

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Posted 13 May 2014 - 03:23 AM

To summarise; Iron Dragon seems ok and pretty well trusted by forum members, whereas the stuff that Sten Labs sells as ALT-711 isn't.


You will however have to write an SA explain that you are not an agent for whoever has the patent on ALT-711 and that you are worthy of ALT-711. With references!
 

 

There is no specific patent holder.  The owners of the patent made it 'public domain' upon dissolution of Synvista Therapeutics, formerly Alteon Pharma.

This is why nobody has taken up the pursuit of further clinical trials.  There is no patent protection, which would make that feasible.  I would not be surprised if the alagebrium base for all that is marketed here would originate in China.  That is, where I get mine from.

 

I understand, that there is further research done in Korea, possibly in the hope of developing a patentable variant.



#23 smithx

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Posted 14 May 2014 - 08:47 AM

Interesting compound.

 

According to this study (https://auth.cardios...ation/Post.aspx) it was beneficial over a year trial in humans, only when combined with an exercise regimen.

 

Also, it's not thiazolium chloride. It's oxo-phenethyl dimethyl thiazolium chloride, CAS 341028-37-3, so I'd be worried about any supplier which said it was selling thiazolium chloride.



#24 StevesPetRat

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Posted 28 November 2014 - 01:57 AM

Bump :) any news in the past year?

#25 Rocket

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Posted 28 November 2014 - 03:11 AM

I've been using this at about 300mg taken in 3 doses daily for about a year. The thing about all the people asking about skin and wrinkles is i don't believe ages play that pivotal a role in withering and wilting the skin. One thing I will say is be careful against ingesting too much at one time... Causes dizziness. Its effect are probably unseen in that it doesn't rejuvenate but probably slows down some affects of aging.

#26 sthira

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Posted 20 December 2014 - 01:41 AM

I've been using this at about 300mg taken in 3 doses daily for about a year. The thing about all the people asking about skin and wrinkles is i don't believe ages play that pivotal a role in withering and wilting the skin. One thing I will say is be careful against ingesting too much at one time... Causes dizziness. Its effect are probably unseen in that it doesn't rejuvenate but probably slows down some affects of aging.


In your year of taking alt-711, what, if anything, have you noticed (other than dizziness)?
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#27 Rocket

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Posted 20 December 2014 - 02:41 AM

No discernible results of any kind. But if I'm keeping internal organs from stiffening with aging that isn't ssomething you'd notice.

The dizziness is from overdose. Also there can be some transient vision sides ffrom overdose.

Edited by Rocket, 20 December 2014 - 02:43 AM.


#28 JohnFurber

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Posted 19 March 2015 - 03:30 PM

Interesting compound.

 

According to this study (https://auth.cardios...ation/Post.aspx) it was beneficial over a year trial in humans, only when combined with an exercise regimen.

 

Also, it's not thiazolium chloride. It's oxo-phenethyl dimethyl thiazolium chloride, CAS 341028-37-3, so I'd be worried about any supplier which said it was selling thiazolium chloride.

 

Good points. It's chemical name is 4,5-dimethyl-3-(2-oxo-2-phenylethyl)-thiazolium chloride (PTC).

ptc.gif

More details on my website http://legendaryphar.../glycation.html  and in my Chapter 19 of The Future of Aging (book. Ed by Greg Fahy.) Chapter 19: Repairing Extracellular Glycation and Aging.

 

I tried to go to your link (auth.cardiosource.org), but got server error 403: access denied.  Could you kindly post the reference citation so that I might find it in the library. Thx!


Edited by JohnFurber, 19 March 2015 - 04:07 PM.


#29 Daniel Cooper

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Posted 26 February 2016 - 06:37 PM

Reviving this old thread.

 

Is Iron Dragon still the preferred provider for alagebrium/alt-711?

 

 

 



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#30 JohnFurber

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Posted 26 February 2016 - 08:03 PM

Hi Daniel Cooper,  regarding Iron Dragon...

Would you really trust a Chinese source?  How would you know what you were getting? How would you test it's purity? How could you get your money back if they send you sugar?

I have worked out the synthesis and purification procedures in my lab at Legendary Pharmaceuticals, and have been consuming my own product daily since 2001. I can help you to obtain some pure experimental material for your own research projects, if you contact me offline.

Some background information can be found on my website www.LegendaryPharma.com/glycation.html  and in my Chapter 19 of The Future of Aging (book. Ed by Greg Fahy.) Chapter 19: Repairing Extracellular Glycation and Aging.

 


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