A good friend's mom has multiple Myeloma and I am looking to design a stack for her.
This study mentions Reishi.
The first problem I have is that I don't know which cell line dosage to look at, and then I don't know how to calculate a dosage from microg/ml or if its even attainable in-vivo??
This is something I need to learn how to do already for all sorts of reasons!
Any other advice also welcome.
Thx in advance
Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.
Müller CI, Kumagai T, O'Kelly J, Seeram NP, Heber D, Koeffler HP.
Source
Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States. MullerCI@cshs.org
Abstract
Over many centuries, herbal remedies have treated a variety of ailments. This empiric observational approach has produced a number of leads for formulated medicines. Ganoderma lucidum extract was screened for its anti-proliferative activity using a panel of 26 human cancer cell lines. The six most sensitive hematologic cell lines were: HL-60 (ED50 26 microg/ml), U937 (63 microg/ml), K562 (50 microg/ml), Blin-1 (38 microg/ml), Nalm-6 (30 microg/ml) and RPMI8226 (40 microg/ml). Cell cycle analyses revealed a G2/M arrest, most prominently in HL-60 cells. Four hematopoietic cell lines (HL-60, Blin-1, U937, RPMI8226) were examined for apoptosis, which ranged between 21 and 92%. After exposure to G. lucidum extract, HL-60 cells became multinucleated with an increased DNA content. These results indicate that G. lucidum extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies.
http://www.ncbi.nlm....pubmed/16423392