120 replies to this topic

[BioFreak]

Bromantane looks interesting, both a stimulant and an anxiolytic with a very good safety profile: http://en.wikipedia....wiki/Bromantane

Although this is not a group buy candidate, It could be a good solution to the anxiety problem.

For the record, I would avoid anything that has bromide in it. Even if it works short term, long term the mental problems with bromide are not worth any positive short term effects.

[Virtual Reality]

FGL also known as FG look.

[jakord]

Bromantane looks interesting, both a stimulant and an anxiolytic with a very good safety profile: http://en.wikipedia....wiki/Bromantane

Although this is not a group buy candidate, It could be a good solution to the anxiety problem.

For the record, I would avoid anything that has bromide in it. Even if it works short term, long term the mental problems with bromide are not worth any positive short term effects.

Well, this is just false. Bromine might be toxic on its own, but not bond to a chemical structure.

[jakord]

OK guys, I'm pretty desperate here.

I'm going to try and start a group buy for two compounds:
partial agonists are better than full agonists:
https://en.wikipedia.org/wiki/ELB-139
then maybe
https://en.wikipedia.org/wiki/Y-23684

They might be a little bit better, but mainly in terms of side effects. I wouldn't consider those substances to deserve the term "Novel anxiolytic". Main problem with effective anxiolytics is tolerance and addiction. I don't think there is much benefit in that regard from ELB-139 compared to taking a low dose of a normal benzo.

[Reformed-Redan]

OK guys, I'm pretty desperate here.

I'm going to try and start a group buy for two compounds:
partial agonists are better than full agonists:
https://en.wikipedia.org/wiki/ELB-139
then maybe
https://en.wikipedia.org/wiki/Y-23684

They might be a little bit better, but mainly in terms of side effects. I wouldn't consider those substances to deserve the term "Novel anxiolytic". Main problem with effective anxiolytics is tolerance and addiction. I don't think there is much benefit in that regard from ELB-139 compared to taking a low dose of a normal benzo.

I think partial agonists are much more preferable than the benzo full agonist shit.

[gnappi]

Hi friends, look at this:
http://en.wikipedia.org/wiki/Validol
http://www.stopacne....10-x-60-mg.html
Anyone tried it?

Edited by gnappi, 21 December 2013 - 10:08 PM.

[Reformed-Redan]

Phenylethylidenehydrazine will be done soon, AFAIK. Need someone with lab access to test this if they can. It's gratis for Q did it! and some other guys who showed prior interest.

[focus83]

Phenylethylidenehydrazine will be done soon, AFAIK. Need someone with lab access to test this if they can. It's gratis for Q did it! and some other guys who showed prior interest.

How much Phenylethylidenehydrazine did you order and from which lab? What's the daily dosage of PEH? I can't remember you ever made a list of participants.

[dijital]

Seems like the group buy for Phenylethylidenehydrazine wasn't public. Are there any experience reports yet?

[golden1]

Phenylethylidenehydrazine will be done soon, AFAIK. Need someone with lab access to test this if they can. It's gratis for Q did it! and some other guys who showed prior interest.

http://reddit.com/r/...t_round/ceyfnsd

if you still need a test

[Reformed-Redan]

Phenylethylidenehydrazine will be done soon, AFAIK. Need someone with lab access to test this if they can. It's gratis for Q did it! and some other guys who showed prior interest.

http://reddit.com/r/...t_round/ceyfnsd

if you still need a test

Thank you.

[socialpiranha]

what about eptapirone, it actually might be oxytocinergic via 5ht1a agonism similar to mdma, shows most robust antidepressant/anxiolytic effects of all the 5ht1a agonists.

[formergenius]

> Bump

Interesting socialpiranha; current 5ht1a agonists indeed leave much to ask for. I'd be interested in synthetic CBD, if it's affordable. I tried CBD as CanChew, which was alright, and as CibDex, which got me high. Both are too expensive though.

Anyway, just bumping this to see if there's still an interest in these substances; Emapunil in particular.

[Reformed-Redan]

I've already tried tofilospam and lamictal for anxiety. There was much to be asked for. Still think SSRI's and a bezno still does the thing. Otherwise just wait for Phenylethylidenehydrazine because Nardil pretty much beat the shiet out of anxiety for me; but, with wayyyy tooooo many side effects.

[Dinvestor]

Is there a group buy for Phenylethylidenehydrazine (PEH)? Can someone respond with some info?

[socialpiranha]

emapunil probably will be similar to etifoxine, they both attach to the 18kda translocater protein site iirc

[Strangelove]

Phenylethylidenehydrazine will be done soon, AFAIK. Need someone with lab access to test this if they can. It's gratis for Q did it! and some other guys who showed prior interest.

Quite interesting, and a possible long term solution for some...

Eptapirone looks very interesting too!

Nice thread.

[celebes]

Eptapirone comes right after JDTic for me.

[stillwater]

I would be interested in Ganaxolone (INN, also known as CCD-1042) if it's a possibility.

 

[Area-1255]

I'll be eventually running another group buy with synthesizer, IDK when yet..but we'll be running a second one. 

 

Tell me ladies and gentlemen, which of these compounds would you want to see in the next group buy?

 

SB-699551  - A 5-HT5A antagonist with anxiolytic and insomnia relieving activity..in theory it would have anti-psychotic activity as well.

http://www.ncbi.nlm....pubmed/16002289

http://www.ncbi.nlm....pubmed/16516972

http://www.ncbi.nlm....pubmed/22785385

 

RITANSERIN - A multi-serotonin receptor antagonist, with main affinity for the type 2AR's but also extends to 5-HT7 receptors , inducing an anti-depressant effect and anxiolytic effect as well as reductions in cortisol, prolactin and ACTH.

 

http://en.wikipedia....wiki/Ritanserin

http://pubchem.ncbi....ound/ritanserin

http://www.ncbi.nlm..../pubmed/2860558

https://books.google...iolytic&f=false

Edited by Area-1255, 02 May 2015 - 11:20 PM.

[YoungSchizo]

I might, if it's affordable for me off course, be in for SB-699551, although, Ritanserin seems like an interesting chemical too. Anyway, I'll go for which of the one is more anxiolytic and anti-psychotic.

[Area-1255]

I might, if it's affordable for me off course, be in for SB-699551, although, Ritanserin seems like an interesting chemical too. Anyway, I'll go for which of the one is more anxiolytic and anti-psychotic.

5-HT5A receptors are similar to 5-HT1A serotonin receptors.

Except they have a strange locale distribution and thus regional territory; mainly in the SCN and other thalamic areas.

 

The 5-HT5A receptors, as stated in this thread of mine. When activated.

 

• Inhibit serotonin release.
• Inhibit GABA release.
• Decrease cAMP.
• Decrease calcium channel activity. (presumably  ↓ nitric oxide)
• Decreased glutamate release due to above.

 

 

When blocked/antagonized you'd have characteristically opposite effects of the above.

 

 

• Potentiation of the glutamate-NMDA-N.O pathway.
• A rise in GABA ; relaxation.  (keep in mind glutamate is needed to convert into GABA)
• Increase in serotonin though likely not to be of significance, because there are other autoreceptors that upregulate in compensation when this receptor is blocked...
• Increased cAMP which may improve some forms of memory, metabolism and will help maintain normal heart rhythms. 

Edited by Area-1255, 03 May 2015 - 04:21 PM.

[Peak Noots]

I will donate 2,000 into this group buy. This chemical is very interesting and would be excited to launch it in our store. It seems to be fully targeting 5ht1a without affinity to other receptors. PM me

[Peak Noots]

Sorry, meant to say a group buy for Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class

[katrina]

My best advice is to get your thyroid checked before doing any of this, even if male.

[Fenix_]

I have been interested in afobazole for a while now.

[Peak Noots]

My best advice is to get your thyroid checked before doing any of this, even if male.

Katrina, can you enlighten us as to why thyroid needs to be checked?

[katrina]

 

My best advice is to get your thyroid checked before doing any of this, even if male.

Katrina, can you enlighten us as to why thyroid needs to be checked?

 

Rampant anxiety is the tip off.  Most doctors will miss simple thyroid disorders as the cause.   Pretty bad if you ask me.

[playground]

Sorry, meant to say a group buy for Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class

 

Flesinoxan... is very interesting.  Will there be a group buy ?

[Area-1255]

still think we should look at 5A  antagonists ---> http://www.ncbi.nlm....pubmed/22785385