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Research nootropic drug / methods map


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#1 3dbrainarray

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Posted 01 October 2013 - 11:47 AM


I would like to propose the creation of new map similary old nootropic doc on google engine but with research drugs ( need to discuss the form and content of the columns). I can add a big number of substances and methods wich are not on the english-language sites. Read longecity many years and just now wanted to make a step forward.
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#2 Absent

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Posted 02 October 2013 - 01:06 AM

Other research drugs like what?
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#3 3dbrainarray

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Posted 02 October 2013 - 02:31 PM


Thiocetam - piracetam with sulfur part.
GLYX-13 - partial agonist of the NMDA receptor - specifically at the glycine binding.
rosavin, siringin, triandrin derivatives
gammoksin, gliprofen, mefebut - have potential
glycolurils:
dizocilpine (MK-801) - non-competitive antagonist of NMDA
xymedon (1,2-dihydro-4 ,6-dimethyl,-C-(a-hydroxyethyl)-2-pyrimidone)- mb have some nootropic activity
Glucagon-like peptide-1 (7-36)--amide (GLP-1
Boc-Ala-Prd-N, Z-Gln-Prd-N, Z-Met-Prd-N
GEBR - 7b
C16 - PKR inhibitor
derinat, taktivin - immunomodulators with nootropic effects
TGS-20, TGS-79 -
Semax
IDRA-21
Neramexane - NMDA antagonist
Nitromemantine - inhibit  excitotoxity
XBD-173 - anti-anxiety 
URB597(KDS4103) - selective inhibitor FAAH.
Polygala Tenuifolia  3,4,5-Trimethoxycinnamic acid (TMCA) - memory and NGF.
Crebinostat - inhibit histone deacetylase activity and modulates chromatine-mediated neuroplasticity.
GTS-21 - activates 
citomax peptides, citogen peptides - I think this just amino acids with very hi price.
nogo-A inhibitors (GSK1223249) (?)
Orexin-A (hypocretin-1) - very interesting (for better mood, wakefulness)
Ciproxyfan - potent histamine H3 inverse agonist/antagonist.
Flowering Quince, Japanese Quince, Mu Gua, Sweet Nakai, and Chaenomeles Lagenaria
INM-176 -  inhibit acetylcholinesterase activity; anti-alzheimer
LY2940094 (Nociceptin/Orphanin)- anti-analgesic
Oxaloacetate - intermediate in the Krebs cycle.
j147 - curcumine derivative 
Indeloxazine- Japanese nootropic.
Teniloxazine - investigated as a neuroprotective and nootropic agent but ultimately developed and approved as an antidepressant in Japan.
Minocycline - antibiotic that has demonstrated neurorestorative as well as neuroprotective properties.
P7C3A20 -  for neurogenesis
Pirisudanol - used in Europe for mild cognitive impairment, fatigue and depression.
Taltirelin -  thyrotropin-releasing hormone (TRH) analog with purported nootropic, neuroprotective and analgesic effects.
Linopirdine - purported cognition-enhancing drug.
Leteprinim - hypoxanthine derivative with neuroprotective and nootropic effects.
Bifemelane - used for senile dementia in Japan.
Ispronicline - neural nicotinic acetylcholine receptors partial agonist with antidepressant, nootropic and neuroprotective effects.
S-17092 - selective Prolyl endopeptidase inhibitor producing nootropic effects.
Cinnamaldehyde, epicatechin - components of cinnamon extract.
Tenoten - antibodies to brain-specific protein S-100B.
Dupracetam -
Dirifiram - 
Harmine, harmaline, harmalol - MAOI
NF-kB inhibitors
ABT-894 - nicotine agonist
ABT-089 (pozanicline) - nicotine agonist
AZD0328 - alpha-7 agonist
Salviae miltiorrhizae Radix - increase gdnf
1-BCP 1-(1,3-Benzodioxol-5-ylcarbonyl)piperidine - some effects on ampa
IDRA-21 7-chloro-3-methyl-3,4-dihydro-2H-1,2, 4-benzothiadiazine S,S-dioxide
TQS (4-(naphthalen-2-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) - positive allosteric modulator (PAMs).
4BP-TQS (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) - allosteric agonist.
α5IA (LS-193,268) - subtype-selective inverse agonist at the benzodiazepinebinding site on the GABAA receptor.
GABAa alpha 5 inverse agonists - potent new nootrpics that work better than AMPArs
Cyclothiazide (3-bicyclo[2.2.1]hept-5-en-2-yl-6-chloro-3,4-dihydro-2H-1,2,4-benzoth ia diazine-7-sulfonamide 1,1-dioxide) (100 microM), a chemical congener of diazoxide, removed the desensitization of the AMPA response
LM22A-4 - small molecule agonist of tropomyosin-related kinase B improves functional recovery from stroke and increases neurogenesis.
Glucagon-like peptide-1 (7-36)--amide (GLP-1) is an endogenous insulinotropic peptide that is secreted from the gastrointestinal tract 
Gilatide - very strange
Fursultiamine - potent disulfide derivate of thiamine.
MEM 1414 -  effect on creb and it is phosphodiesterase blocker
Picavite
Acorus calamus - like it in big dosage
Entacapone+ L-dopa+carbidopa
Rivastigmine - cholinergic agent
Ropinirole - agonist of D 2,3,4
Iron chelator M30 [5-(N-methyl-N-propargyaminomethyl)-8-hydroxyquinoline] - iron chelators very potent.
Mecamylamine - used for hypertension, but also nicotinic receptor antagonist alpha-7.
Org 26576 - ampakine.
Daidzein, genistein, glycitin - isoflavones with nootropic effects.
MitoQ - antioxidant 
Thymosine beta 4 - have anecdotal nootropic effects.
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#4 3dbrainarray

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Posted 02 October 2013 - 02:41 PM

Decoded Neurofeedback (DecNef)

Trigeminal nerve stimulation

rTMS

Transcranial random noise stimulation

Tendlite

Brain implants, shunts, arrays

Transcranial direct current stimulation

#5 Mind

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Posted 26 October 2013 - 12:46 PM

What type of database structure would be best for this effort?

#6 YOLF

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Posted 21 April 2014 - 06:03 PM

I think just using a google doc would work. This looks like a very interesting list. I'd hate to see it buried again.



#7 3dbrainarray

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Posted 26 April 2014 - 08:55 PM

Ok I will do it on google doc tomorrow.
Where I can put it on the forum?

#8 YOLF

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Posted 27 April 2014 - 08:16 AM

Great of you to step up 3DBrain :) You can start a topic in the nootropic stacks sub forum, or you could start a blog.






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