So, as far as anxiolytics are concerned I think Neuropeptide S beats them all. Here is a wiki exert:
Neuropeptide S
(NPS) is a neuropeptide found in human and mammalian brain, mainly produced by neurons in the amygdala and between Barrington's nucleus and the locus coeruleus, although NPS-responsive neurons extend projections into many other brain areas.[1][2][3] NPS binds specifically to a newly de-orphaned G protein-coupled receptor, NPSR.[4][5] Animal studies show that NPS suppresses anxiety and appetite, induces wakefulness and hyperactivity, including hyper-sexuality, and plays a significant role in the extinction of conditioned fear.[6][7][8][9][10][11][12] It has also been shown to significantly enhance dopamine activity in the mesolimbic pathway.[12]
These effects seem very positive and since anxiety and all other neurological disorders are interrelated, such as depression, then I suspect that some gene or other type of dysfunction in the production or receptor disruption with Neuropeptide S may be related closely to them, specifically anxiety disorders.
I'm wondering how or if anyone has any more information on how to stimulate the production of Neuropeptide S in the CNS. Seems like a potent and safe way to combat anxiety. I'm thinking BDNF closely regulates the production of NPS, though exactly in what manner, I'm unsure. Any more info much appreciated on this. Hell, if anyone is a medicine major, this would be one helluva topic to write a paper on and get a good review on.