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Neuropeptide S

stimulating neuropeptide s anxiety

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#31 Infinite1

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Posted 30 October 2014 - 07:37 PM

Anyone else have any self reports?



#32 Ezeon

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Posted 31 October 2014 - 08:50 AM

How did you suspend it?  

 

A standard saline solution.



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#33 medievil

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Posted 29 November 2014 - 10:22 AM

Neuropeptide S (NPS) may help in treating schizophrenia
Jul 10, 2006, 06:18, Reviewed by: Dr. Ankush Vidyarthi
   
"Although preliminary, our animal studies indicate the NPS receptor should be explored as a target for the development of novel antipsychotic drugs. Whether molecules activating the NPS system will prove to be better drugs than others used to treat the symptoms of schizophrenia remains to be seen. We still have a very long way to go before proving it can alleviate symptoms in humans as we've seen it do in rodents"

 

  

By University of Pittsburgh Medical Center, A small protein in the brain that has only recently been discovered and, paradoxically, induces both profound wakefulness and a less anxious state, may represent a novel target for the treatment of psychotic behavior and schizophrenia, according to new research presented at the 6th International Congress of Neuroendocrinology (ICN 2006) recently. 

Neuropeptide S (NPS), so named by Rainer K. Reinscheid, Ph.D., assistant professor, Program in Pharmaceutical Sciences, University of California, Irvine, is produced by a small cluster of cells in the brainstem, yet its specialized receptors are found in several areas of the brain, including those that are associated with the regulation of arousal, sleep and wakefulness, anxiety, appetite, learning and memory. Dr. Reinscheid and his colleagues reported finding the new neuropeptide just last year and described animal studies showing how binding of NPS to its receptors on the surfaces of neurons promotes strong arousal, suppresses all phases of sleep and lessens anxiety in stressful or unfamiliar situations.

Dr. Reinscheid's group reports how NPS also can reduce the biochemical and behavioral symptoms of schizophrenia in an established animal model for this mental illness that affects some 2 million Americans. Animals pretreated with NPS before receiving a drug that normally induces psychotic-like behaviors did not develop the signature behavioral symptoms and neurochemical features of schizophrenia, reported Naoe Okamura, M.D., Ph.D., who is a co-worker of Dr. Reinscheid at the University of California, Irvine.

"Although preliminary, our animal studies indicate the NPS receptor should be explored as a target for the development of novel antipsychotic drugs. Whether molecules activating the NPS system will prove to be better drugs than others used to treat the symptoms of schizophrenia remains to be seen. We still have a very long way to go before proving it can alleviate symptoms in humans as we've seen it do in rodents," said Dr. Reinscheid.

"We've already seen how NPS is unique, being able to modulate both arousal and stress responses. So it could potentially be a target for drugs to treat anxiety and, interestingly, both insomnia and narcolepsy," he added.

The receptor for NPS belongs to a class of those with similar structure called G protein-coupled receptors. Collectively, they have a hand in modulating most every physiological process in the body and brain. Moreover, according to Dr. Reinscheid, about 40 percent of drugs on the market target the function and various actions of these receptors.

Dr. Reinscheid's lab is only beginning to understand how the NPS system works. Thus far, the team's research suggests it acts much like an excitatory neurotransmitter that initiates an impulse by the receiving neuron. Currently, the team is looking at whether natural mutations in the genes of NPS and its receptor might be associated with mental disorders and developing animal models that lack parts of the NPS system in order to better understand its functions. 
 fullstop.gif

- 6th International Congress of Neuroendocrinology (ICN 2006)
 

www.upmc.edu 

 

 


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#34 Babychris

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Posted 29 November 2014 - 02:44 PM

Man I'm going to see the police you're really kidding me and I don't like that. 


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#35 medievil

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Posted 29 November 2014 - 02:53 PM

Man I'm going to see the police you're really kidding me and I don't like that. 

read the other thread, i really apologise, i allways intended to pay you back but what we agreed was too much as i need money for stims, i agreed to pay the other guy 20 pound everytime i can, give me a few days otherwise feel free to go to the police, if you want to do that email me to askl my name please dont involve the person that received the money who is innocent:



#36 medievil

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Posted 29 November 2014 - 02:55 PM

i wanted to pay you last time when i said i could but ended up buying a laptop, i admit i think too much of myself when others need the money, again sorry and lets leave this discussion in the other thread.



#37 tolerant

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Posted 01 January 2017 - 10:12 PM

I want to bump this thread. Here are just some of the studies to have been published since this thread has last been active (with brief conclusions). The first two studies overlap with the currently active threads on KOR antagonists and HDAC inhibitors, respectively.

 

https://www.ncbi.nlm...pubmed/27013974 ("Therefore, the endogenous opioid dynorphin is suited to inhibit NPS neurons with a subsequent decrease in NPS release in putative target regions leading to a variety of physiological consequences such as increased anxiety or vulnerability to stress exposure.")

 

https://www.ncbi.nlm...pubmed/26625894 ("By using the potentially nonsedative anxiolytic neuropeptide S and the cognitive enhancer D-cycloserine to facilitate deficient fear extinction, we provide here the first evidence of a purported efficacy of a dual over a single drug approach. This approach may render exposure sessions less aversive and more efficacious for patients, leading to enhanced protection from fear relapse in the long term.")

 

https://www.ncbi.nlm...pubmed/27883964 ("The brain neuropeptide S (NPS) system has recently generated substantial interest and may be of major relevance for central stress regulation. The NPS receptor (NPSR1) is highly expressed in the limbic system, exogenous NPS exerts pronounced anxiolytic and fear-attenuating effects in rodents and extensive close crosstalk between the NPS system and the hypothalamic-pituitary-adrenal (HPA) axis has been demonstrated. In humans, associations between NPSR1 variants and anxiety and panic disorder, as well as amygdala responsiveness to fear- relevant faces and prefrontal cortex activity in a fear conditioning paradigm have been reported. Moreover, a NPSR1 sequence variant was found to be associated with cortisol stress responses in males.")

 

https://www.ncbi.nlm...pubmed/27784496 ("Up-regulated interleukin-6 and tumor necrosis factor-alpha in asthma can inhibit the secretion of neuropeptide S in neuronal cells. The decline of brain neuropeptide S, which has anti-anxiety effect, may lead to the occurrence of anxiety, which may be a potential mechanism of comorbidity of asthma and anxiety.")

 

https://www.ncbi.nlm...pubmed/27044664 ("Taken together, our study extends the potent anxiolytic profile of NPS to a social context by demonstrating the reduction of social fear and social avoidance, thus providing the framework for studies investigating the involvement of the NPS system in the regulation of different types of social behaviour.")

 

https://www.ncbi.nlm...pubmed/25830625 ("Collectively, our study uncovers a multifaceted high-anxiety neurophysiological endophenotype in the murine ventral hippocampus and provides the first evidence that an intranasally applied neuropeptide can shift such an endophenotype in an anxiety-regulating brain structure towards a "normal"-anxiety one".)

 

The main question I have is the following: Is this product legit?

 

 

 



#38 Reformed-Redan

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Posted 02 January 2017 - 07:33 PM

The main question I have is the following: Is this product legit?

Yes, it is legit. Back in the heyday, I worked closely with THT to develop BPAP, Pitolisant, and GTS-21.

 

Only reason why the prices are quite high from THT is because the owner decided to orient his product to research labs and such institutions instead of individuals.

 

I am actively searching for compounds that stimulate the production of NPS directly or via other routes. It's a highly promising compound given my short trial with taking it via the ocular route, much like how one would take NGF. 



#39 tolerant

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Posted 02 January 2017 - 11:19 PM

 

The main question I have is the following: Is this product legit?

Yes, it is legit. Back in the heyday, I worked closely with THT to develop BPAP, Pitolisant, and GTS-21.

 

Only reason why the prices are quite high from THT is because the owner decided to orient his product to research labs and such institutions instead of individuals.

 

I am actively searching for compounds that stimulate the production of NPS directly or via other routes. It's a highly promising compound given my short trial with taking it via the ocular route, much like how one would take NGF. 

 

 

I don't think the price is high. ΨChemicist calculated the HED to be 0.5 mg, meaning that for $175 you get 1000 doses. Maybe it's the concerns about NPS being carcinogenic that is stopping people from trying it.



#40 BlueCloud

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Posted 12 January 2017 - 09:57 AM

I don't think the price is high. ΨChemicist calculated the HED to be 0.5 mg, meaning that for $175 you get 1000 doses. Maybe it's the concerns about NPS being carcinogenic that is stopping people from trying it.


But if NPS isn't supposed to be taken on a regular basis, but only on sporadic occasions to help extinct the specific fears, perhaps the carcinogenic aspect isn't of much concern ? Do we know how long one has to take NPS before the carcinogenic effects start appearing ?

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#41 mrak1979

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Posted 02 February 2017 - 12:38 AM

If one were to cycle this on a regular basis, what would a good schedule look like?







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