3 replies to this topic

[nootrop1097]

Im wondering what is the order of most stimulating / activating to least stimulating for these antidepressants:

Wellbutrin, Remeron, Effexor, Prozac, Prestiq, Cymbalta, Zoloft, Parnate and Nardil

[NeuroNootropic]

Remeron and Nardil are actually sedating rather than stimulating. My best guess of the order of most stimulating to least is:

• Wellbutrin
• Parnate (on top of being an irreversible MAOI, it acts like an amphetamine, but with 1/10 its potency)
• Prozac (many users claim it's activating. Possible mechanism is the 5-HT2C antagonism which disinhibits dopamine and norepinephrine release in the prefrontal cortex)
• Effexor
• Prestiq
• Cymbalta
• Zoloft (mild dopamine reuptake inhibitor)
• Nardil
• Remeron (used as a sleep aid)

[nootrop1097]

ive read by searching through goolge that Prestiq is more stimulating than effexor and effexor is more stimulating than prozac.


heres one site:
http://www.crazyboar...mulation-scale/

[Tom_]

There is no way to answer that question - people respond very differently.

With Tranylcypromine for example a lot of people find it quite sedating.

Typically at lower doses Venlafaxine is quite sedating while above 200mg it becomes quite activating. Duloxetine for example is a slightly stronger NRI than Venlafaxine and so tends to be more activating. Bupropion is nearly always stimulating however. So other than placing Bupropion at the top you can't really decide one is more stimulating than another.

AD's more stimulating than Bupropion include: Reboxetine, Protriptyline and possibly Desipramine.