5 replies to this topic

[ComfortablyNumbb]

I have a regimen I’m looking for some input on - my goal is to get rid of my emotional flatness, mental dullness and concentration issues that have come from a period of high anxiety and a series of weed-induced panic attacks.

For a while I felt I was experiencing chronic depersonalization, but what I feel now, while similar in that I still feel disconnected, feels more like plain depression/apathy/burnout, mixed with a bit of anxiety. I’m not “down” about myself or my life, it just seems to pass by me in a haze. If anyone’s interested in more details, I can give them.

I’d hugely appreciate any advice – additions, subtractions, dosages, method of administration, etc..


The Regimen ----------------

[* = Supplements I’ve already been taking for a few weeks and feel stable, and maybe a bit better than usual on]

*ALCAR – 1x500mg, 1x Daily

*NAC - 2x600mg, 2x Daily

*Vitamin C – 2x1000mg, 2x Daily

Noopept – 1x15mg, 2x Daily, Sublingually

Lion's Mane – 1x3g, 1x Daily

UMP – 1x250mg UMP, 2x Daily, Sublingually,

Fish Oil - (400mg DHA + 400mg EPA) – 1x Daily

*Rhodiola – 2x170mg, Daily

*Ashwaghanda (Jarrow's Sensoril) - 1 Cap Daily [seems to make me sleepy so I'm thinking about taking it before bed]

*B-Complex - 1 Daily

*Zinc – 1x50mg, 1x Daily



Thanks!

[InBetween]

Hey, that stack looks promising - could you tell me which differences in your mood, cognition etc. you felt?

[Peak Noots]

Try adding mucuna pruriens. It is a dopamine enhancer by enhancing L-dopa (direct precursor to dopamine). It also helps to raise seretonin levels. If that works try to get your hands on some selegiline

[Peak Noots]

I was just thinking I wrote a post on one of our sites relating to this http://elitenootropi...e-low-dopamine/

[Flex]

For the flat emotions could the striatum( a hypofunction) be blamed.
Especially the caudate( as far as i Know im just an Amateur, but have also some similair problems).

Also maybe responible for the motivation .
But an overactive striatum could increase anxiety.
(MAO-B inhibition could help in this terms, or a 5-ht2a agonist and/or a 5-ht2c antagonist

Furthermore, maybe the increase of d3 receptors in the nucleus accumbens could lead to Motivation Problems.
(at least for me helped in this Terms, cyproheptadine a h1, 5ht-2a.b.c and d3 antagonist)

Hope that i could help.
But be VERY carefull with self-medication.
Ive destroyed my allready (THC)damaged brain with Ritalin!!

[Flex]

Ok this is the thing when someone is not a Doctor..sigh, so I.

 

Found out that the Anterior Cingulate Cortex could also be involved in some those terms.

 

Anterior cingulate cortex regulation of sympathetic activity

Given the findings that relate cognitive processes to the ACC, it is somewhat surprising that lesions to the ACC do not produce massive or consistent cognitive deficits. Early on, it was recognized that patients with lesions to the frontal lobe, including the ACC, demonstrated normal performance on a host of neuropsychological and intelligence tests (Rylander, 1947; Teuber, 1964). More recent studies have basically confirmed these early observations, but they also show that patients with ACC lesions do demonstrate performance deficits on the Stroop task and other tasks that have been shown to activate the ACC (Cohen et al., 1999; Ochsner et al., 2001). Perhaps the most consistent observation regarding changes associated with lesion of the ACC is with regard to affect. These patients have been described as apathetic and unconcerned when significant events occur, such as making mistakes (Eslinger and Damasio, 1985; Rylander, 1947).

http://brain.oxfordj...26/10/2119.full

 

Apathy following stroke.

...It appears to be associated with the presence of cognitive impairment, a chronic course characterized by progressive functional decline, and with disruption of neural networks connecting the anterior cingulate gyrus, the dorsomedial frontal cortex, and the frontal pole with the ventral aspects of the caudate nucleus, the anterior and ventral globus pallidus, and the dorsomedian and intralaminar thalamic nuclei....

 

...Cholinesterase inhibitors and nefiracetam may significantly reduce apathetic symptoms. However, their efficacy was examined in relatively small clinical trials that require replication...

http://www.ncbi.nlm....ingulate cortex

 

Furthermore: Only wikipedia and the link to a database, claims that Cyproheptadine is a dopamine d3 inhibitor.

I could not find it anywhere else and I heard that wiki is not very reputable.

So, dont know.

Edited by Flex, 27 June 2014 - 05:49 PM.