rapamycin reduces intracellular aging
but it can inhibit mTORC2 which can cause insulin resistance
insulin resistance isn't necessarily bad in those who are CR and who
have naturally low glucose levels. but in those who aren't CR'ed
already... then couldn't it lead to higher glucose levels in those who
take rapamycin? which could attenuate its decrease in extracellular
aging - e.g. crosslinks