9 replies to this topic

[protoject]

Hey guys, so I'm not sure if there actually is a solution to this problem I'm having, but here's the deal.

I have severe insomnia which is uncontrollable by many behavioral and medical means.

I have found some medical means to control the insomnia pretty well.

However the meds leave me with daytime side effects.

Particularly I'm looking at pregabalin.

I'm wondering if any of you have any ideas on how to reverse the pharmacological effects of this med during the day time by using some other med or supplement to stop those effects. The main effects I'm concerned with are cognitive and emotional dulling, including memory impairment. .

Taking pregabalin occassionally doesn't cause much of a problem but if I take it daily it practically malleates my brain. I can't have this happening but the fact of the matter is I need my sleep and there is no other way around it.

Actually, Eplivanserin works good as well, and without those side effects from pregabalin, however I only have a chinese version of it which is probably contaminated with something, unfortunately. So if anyone has suggestions for where I can get high quality eplivanserin I'm also open to that. . . .

[damon]

I've found small amounts of caffeine (< 100 mg) is useful to offset the mental fog of gabapentin (never tried Lyria).

[protoject]

How about NSI-189 people? or would the acute effect of synaptogenesis not be present, is it more of an over-time thing?

[protoject]

I just found a study saying that donepezil would reduce the "somnolence" effect of pregabalin.

I have galantamine, I think..... somewhere stashed away. Which is similar. Right?

I have been back on a higher dose of pregabalin due to etizolam withdrawal/ bad insomnia.. so I might try it. 

 

I kind of don't want to because I don't remember liking galantamine's effects. Also I am wondering if it would work in the exact same way as donepezil for the issue, and, whethere its "somnolence" deleting effect is what I'm looking for. (is my brain being swiss-cheezish meaning somnolence? what about this fatigue I am having? I thought somnolence was more of a sleepy or drowsy thing, unless im wrong)

[drg]

Valproic acid worked similar to pregabalin for sleep for me. Though it is an older medication with probably similar cognitive effects but you never know how you will respond without trying it.

 

I tried NSI with pregabalin several times. It is hard to say whether the NSI effected the cognitive effects I usually experienced with Pregabalin. I was only taking the pregabalin when I was desparate to get some sleep, not every day like I did when I noticed cognitive effects of pregabalin. But I would say I though the cognitive effects were much less noticeable with NSI.

 

NSI189 has acute and gradual effects, according to most people reporting their experience

[protoject]

Thanks for the response.  I made this post a year ago and never ended up bothering to buy galantamine for this purpose. (i couldn't find the galantamine in my stash the whole time).  However I just found my galantamine so I might try this soon.

[protoject]

Ok so it's working!!!!

 

I got the idea from http://conference.pa...s/08/288-46.pdf

It won't let me copy and paste.

 

 

Anyway I found my stash of galantamine from years ago.

 

Started using a lot more pregabalin at night- about 160 mg now- a dose which before would make me turn completely retarded the next day.

 

I've been taking 8 mg of galantamine every day in the morning and it seems to be helping cognitive function quite a bit in regards to pregabalin. It's even a bit energizing at times.

 

I'm pretty surprised that it worked

 

 

it's not perfect but it's definitely working

 

edit: I've only done this for about 3 days so far

edit2: Yes I know the study is about Donepezil not galantamine, though they do almost the same thing.

Edited by protoject, 05 February 2015 - 07:11 PM.

[protoject]

It's been about 7 days now and it is still working.

 

I've even escalated my pregabalin dosage.

 

Not sure if this is just some strange coincidence.

 

But let me put it this way. Usually if I took 150-200 mg for a couple days my mind would be destroyed the next day (usually extreme mind fog, inability to remember words, to do any mental work such as math, depressed etc)

 

Even doses somewhat lower than that messed up my mind.

 

It seems that with galantamine now I can go up to a good 500 of pregabalin and still maintain mental function.

 

I take pregabalin at night BTW, no other time.

 

So what do you think guys? Coincidence or not?

 

8 mg galantamine is what I'm using. If it use 16 mg it makes me depressed. 8 seems pretty good.

I'm thinking the effect might last for a while too. I haven't taken it today yet but I can still feel it from yesterday (but not as strongly obviously).

 

Anyone else on gabapentin (sometimes mockingly called Morontin to make fun of its real name Neurontin, because it turns you into a moron)

or pregabalin?

 

Maybe wanna give this a shot and report back?

 

 

[riloal]

Hi, protoject, any report on how are you doing? Thanks

[AlexCanada]

Gabapentin is oddly one of the few medications to relieve anhedonia in me at some level at 3+ hours after dosing. Initially there is sedation, dullness and low emotion though.  But I generally have super low emotion and reaction anyway.  Yet somehow 3 hours after gabepentin I have bit more subtle interest, sometimes capable of even becoming ''excited'' (very rare for me), and even a bit engaged in a tv program, + pro-social and easy going effects.    Does anyone know why this happens? At the same time there is usually some notable stupor esp w name recall though yet the heightened functionality and improved sense of well-being make up for it.  And what alternative medications or supplements may help create such an effect?    It's like there is some jolt of life in me from gabapentin during those moments and even positive adrenaline but tolerance to such effects is pretty quick.   Yet if I stop for 3+ days and start again there is such a sense of euphoria that arrives and notable anti-depressant action. 

 

I have low Testosterone, Low E, hypothyroid, very low cortisol, CFS, poor memory + cognition, all negative schizophrenia symptoms, anhedonic amotivational type of depression. Also dealing w long protracted valium taper withdrawal. Severe lack of emotion and lack of thought.  Like I'm in some deep Hypo state.    

Edited by AlexCanada, 02 January 2016 - 03:09 AM.