7 replies to this topic

[udinesio]

Hey,

I'm doing some research on neuroplasticity and am interested on stimulating it. It's a long story and everyone is probably going to laugh, but I want to stimulate it to a point I'd have the same learning abilities as a kid. Due to my lack of luck, I wasn't born in the best place out there. Because of that I have problems to do things that are considered normal. I didn't learn them when I was supposed to and now that I'm 20 years old it's extremely hard to learn them. I'm still beginning my research, but as far as I know the main thing here is the AMPA-receptor. Dopamine and noradrenaline seem to play a hole.

Basically I intend to take methylphenidate for a while and try to stimulate the AMPA receptors as much as I can. Does anyone know where I can get ampakines? Which ones are more effective? It might seem weird, but I'm willing to make them at home if needed/possible. Also, is there a risk of downregulation because of ampakines use? Are there other drugs to stimulate AMPA receptors? Like something that stimulates the release of Glutamate.

I know there are risks and side effects and they can be more complicated with experimental drugs and I'm interesting on knowing all of them before starting. Still, even if those risks are huge, it's worth trying it. I have way too many problems that can only be solved by stimulating plasticity and they're fucking me up a lot. It's not really worth living the way I'm living now. After thinking about it for some time, I decided I'm willing to take the risk.

Thanks!

[Debaser]

What things didn't you learn as a kid? The only things I can really think of which are significantly easier to pick up as a child are languages and playing musical instruments, but these are things that can still be learnt in adulthood if you put the time in. According to Malcolm Gladwell / Anders Ericsson, spend 10,000 hours on anything and you can master it.

[Jeoshua]

Monoamine neurotransmitters are certainly important, but any large scale plasticity of the human body in general is going to require hormonal support. How old are you, udinesio? I ask because if over the age of 30, you could look into Pregnenalone, which would encourage myleination, dendritic growth, and overall stress relief... but only if you're low in it. If you're 18 it won't do a thing for you.

[udinesio]

Monoamine neurotransmitters are certainly important, but any large scale plasticity of the human body in general is going to require hormonal support. How old are you, udinesio? I ask because if over the age of 30, you could look into Pregnenalone, which would encourage myleination, dendritic growth, and overall stress relief... but only if you're low in it. If you're 18 it won't do a thing for you.

I'm 20, but I got into andropause when I was 13. I'm currently in T shots

What things didn't you learn as a kid? The only things I can really think of which are significantly easier to pick up as a child are languages and playing musical instruments, but these are things that can still be learnt in adulthood if you put the time in. According to Malcolm Gladwell / Anders Ericsson, spend 10,000 hours on anything and you can master it.

No matter how much I try, I cannot trust or build emotional ties with people. I also have trouble to write/draw. And I have to learn Dutch(as I'm going to move to Holland soon) and am learning how to sing and play the guitar. I can benefit a lot from this.

[Flex]

Monoamine neurotransmitters are certainly important, but any large scale plasticity of the human body in general is going to require hormonal support. How old are you, udinesio? I ask because if over the age of 30, you could look into Pregnenalone, which would encourage myleination, dendritic growth, and overall stress relief... but only if you're low in it. If you're 18 it won't do a thing for you.

I'm 20, but I got into andropause when I was 13. I'm currently in T shots

What things didn't you learn as a kid? The only things I can really think of which are significantly easier to pick up as a child are languages and playing musical instruments, but these are things that can still be learnt in adulthood if you put the time in. According to Malcolm Gladwell / Anders Ericsson, spend 10,000 hours on anything and you can master it.

No matter how much I try, I cannot trust or build emotional ties with people. I also have trouble to write/draw. And I have to learn Dutch(as I'm going to move to Holland soon) and am learning how to sing and play the guitar. I can benefit a lot from this.

-Overstimulation of Ampa receptors( or any other glutamate ones) will cause Apostosis ( Neuronal cell death) !
especially in conjunction with a alpha2 atagonist
same game with Calcium releasing agents

Be careful with Dopaminergics, too much release will cause Dopamine to oxidize, so --> Cell Death.
But can be prevented with mao-a alltough eventual bloodpressure (or maybe bloodthinning) changes could occur

Let me tell You that Desperation caused by misfortune or a sad Life
is the ultimative men´s poison.
It brings the smartest people to do the Stupidest things, and cause more pain than before.
( especially if You hurry up with Your decision and dont take propper time to rethink)

Therefore, please dont try to reach some things at any cost.
------
# You could learn about the effects of Cocaine and do the exact opposite ( further advice; do never take it. I know what I´m talking about, or take a look at ncbi.nlm.nih.gov/pubmed )
# Read about LTP (long term potentiation)
# Thc could help You or make it worser in regards learning/cognition. But dont make it to a habbit

# Change the way of thinking like more flexible thinking. This and to like what You´re learning will compensate the worser learning compared to childhood.
Because this helped me when I went with 27 Years again to School

Edited by Flex, 26 February 2014 - 04:54 PM.

[JPC16]

That “childlike learning state” you are referring to is called the critical period.
And as far as I know, the only way to reinduce that critical period is by agents that cause histone deacetylase-inhibition. Valproic acid is such an inhibitor that (with the correct training) can actually give you an absolute pitch (http://www.ncbi.nlm....les/PMC3848041/). But valproic acid in itself woudn't be an ideal neuroplasticity enhancer since it has a GABAergic effect. You should look into compounds such as Vorinostat and Romidepsin.

I am actually theorizing that if you combine substances like valproic acid with an intense training regimen on inductive reasoning, that you could enhance your fluid intelligence. Here is a study wherein a modest transfer effect occurred: http://www.sciencedi...361476X01910793
I would also like to note that genetic influences on IQ are as “low” as 26% during the critical period (http://en.wikipedia....of_intelligence). So there might be a good chance that this strategy actually works. This would be the world's first fluid-intelligence-enhancing-method in adults.

Maybe a combo with dihexa would be interesting? Or one could maybe use it in combination with TDCS or TRNS, to give the cortical areas involved in fluid intelligence (http://decisionneuro..._et_al_2013.pdf) an extra "boost"?

Edited by JPC16, 26 February 2014 - 08:55 PM.

[celebes]

HDAC2 inhibitors https://drive.google...dit?usp=sharing

Edited by celebes, 26 February 2014 - 09:25 PM.

[Flex]

Edit

Edited by Flex, 20 March 2014 - 01:12 AM.