I'm surprised, but here it is:
http://www.ncbi.nlm....les/PMC3360794/
Antiviral Res. Author manuscript; available in PMC 2013 June 1.
Published in final edited form as:
Antiviral Res. 2012 June; 94(3): 258–271.Published online 2012 March 23. doi: 10.1016/j.antiviral.2012.03.005
PMCID: PMC3360794
NIHMSID: NIHMS365909
Quercetin inhibits rhinovirus replication in vitro and in vivo
Shyamala Ganesan,1 Andrea N. Faris,1 Adam T. Comstock,1 Qiong Wang,1 Suparna Nanua,1 Marc B. Hershenson,1,2 and Uma S. Sajjan1
1Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA 48109
2Department of Internal Medicine, 2Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA 48109
*Address correspondence to: Uma Sajjan, Ph.D., University of Michigan, 1150 W. Medical Center Dr., Room 3570, MSRBII, Box 5688, Ann Arbor, MI USA 48109-0688. Phone: (734) 936-4200; FAX: (734) 764-3200; Email: usajjan@umich.edu
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Summary
Rhinovirus (RV), which is responsible for the majority of common colds, also causes exacerbations in patients with asthma and chronic obstructive pulmonary disease. So far, there are no drugs available for treatment of rhinovirus infection. We examined the effect of quercetin, a plant flavanol on RV infection in vitro and in vivo. Pretreatment of airway epithelial cells with quercetin decreased Akt phosphosphorylation, viral endocytosis and IL-8 responses. Addition of quercetin 6 h after RV infection (after viral endocytosis) reduced viral load, IL-8 and IFN responses in airway epithelial cells. This was associated with decreased levels of negative and positive strand viral RNA, and RV capsid protein, abrogation of RV-induced eIF4GI cleavage and increased phosphorylation of eIF2α. In mice infected with RV, quercetin treatment decreased viral replication as well as expression of chemokines and cytokines. Quercetin treatment also attenuated RV-induced airway cholinergic hyperresponsiveness. Together, our results suggest that quercetin inhibits RV endocytosis and replication in airway epithelial cells at multiple stages of the RV life cycle. Quercetin also decreases expression of pro-inflammatory cytokines and improves lung function in RV-infected mice. Based on these observations, further studies examining the potential benefits of quercetin in the prevention and treatment of RV infection are warranted.