7 replies to this topic

[cudBwrong]

I'm surprised, but here it is:

http://www.ncbi.nlm....les/PMC3360794/

Antiviral Res. Author manuscript; available in PMC 2013 June 1.
Published in final edited form as:

Antiviral Res. 2012 June; 94(3): 258–271.Published online 2012 March 23. doi: 10.1016/j.antiviral.2012.03.005

PMCID: PMC3360794
NIHMSID: NIHMS365909
Quercetin inhibits rhinovirus replication in vitro and in vivo


Shyamala Ganesan,¹ Andrea N. Faris,¹ Adam T. Comstock,¹ Qiong Wang,¹ Suparna Nanua,¹ Marc B. Hershenson,^1,2 and Uma S. Sajjan<sup>1


1</sup>Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA 48109
²Department of Internal Medicine, ²Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA 48109
^*Address correspondence to: Uma Sajjan, Ph.D., University of Michigan, 1150 W. Medical Center Dr., Room 3570, MSRBII, Box 5688, Ann Arbor, MI USA 48109-0688. Phone: (734) 936-4200; FAX: (734) 764-3200; Email: usajjan@umich.edu
Author information &#9660; Copyright and License information &#9658;


The publisher's final edited version of this article is available at Antiviral Res
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Summary


Rhinovirus (RV), which is responsible for the majority of common colds, also causes exacerbations in patients with asthma and chronic obstructive pulmonary disease. So far, there are no drugs available for treatment of rhinovirus infection. We examined the effect of quercetin, a plant flavanol on RV infection in vitro and in vivo. Pretreatment of airway epithelial cells with quercetin decreased Akt phosphosphorylation, viral endocytosis and IL-8 responses. Addition of quercetin 6 h after RV infection (after viral endocytosis) reduced viral load, IL-8 and IFN responses in airway epithelial cells. This was associated with decreased levels of negative and positive strand viral RNA, and RV capsid protein, abrogation of RV-induced eIF4GI cleavage and increased phosphorylation of eIF2α. In mice infected with RV, quercetin treatment decreased viral replication as well as expression of chemokines and cytokines. Quercetin treatment also attenuated RV-induced airway cholinergic hyperresponsiveness. Together, our results suggest that quercetin inhibits RV endocytosis and replication in airway epithelial cells at multiple stages of the RV life cycle. Quercetin also decreases expression of pro-inflammatory cytokines and improves lung function in RV-infected mice. Based on these observations, further studies examining the potential benefits of quercetin in the prevention and treatment of RV infection are warranted.

[YoungSchizo]

Ah cool, I didn't had the flu yet but I'm already prepared for it by ordering Quercetin. (I bought it just to see if it has some and/or I notice some health benefits, so let the flu come at me )

Edited by YoungSchizo, 04 February 2014 - 05:48 PM.

[caruga]

In my experience, quercetin makes me feel very strange in the head, and not in a good way.

[Dorian Grey]

"Pretreatment of airway epithelial cells with quercetin"... Do you snort it?

Edited by synesthesia, 04 February 2014 - 10:38 PM.

[cudBwrong]

"Pretreatment of airway epithelial cells with quercetin"... Do you snort it?

HaHa good question, it's a little confusing. This report covers two experiments, one in vitro and one in vivo.

The pretreatment refers to treatment of cells in glass plates.

The live animals were gavaged with a solution containing quercetin or vehicle.

[Roshambo]

The article didn't really specify the differences in efficiency between the in vitro and in vivo tests, but this could be monumental if clinical trials on humans are persued.

[cudBwrong]

The article didn't really specify the differences in efficiency between the in vitro and in vivo tests, but this could be monumental if clinical trials on humans are persued.

I used to get very intense colds, several per season, lasting weeks, so bad I would be sleeping in a chair so my lungs would not fill up. As an experimental therapy for a retina disease, I've been taking resveratrol for about 3.5 years, plus quercetin for about half that time. During that period, I had one real cold, lasting 2 weeks, at the height of flu season. (I had the vaccine, but it's not completely effective). I had several other episodes when I was sure my luck had run out, feeling feverish, bad sore throat, here it comes, and the next morning ... nothing. Completely gone.

This is anecdotal, but the plural of anecdote is data.

[Logic]

Note that the Quercetin is only shown to be effective against one strain of bacteria by the linked study.
Flu is caused strains other than Rhinovirus.
Fortunatly these are all lipid coated virii and can thus be cured by substances that disrupt the coating such as EVCO and BHT.

 

Thx for the info though.  Now I'm covered for colds and flu!