5 replies to this topic

[MrKappa]

So, after some time, I've been thinking about making solutions of a handful of nootropics and administering the dose through my ear.

I'll let everyone else decide how good or bad an idea that is based on the various drugs they take.

Me specifically, I am interested in anti-viral, anti-fungal and anti-bacterial drugs.

Administering various drugs through the ear. Will that cross the blood brain barrier? Are there any unforseen issues that may be something to consider?

Thank you for any information provided.

[lammas2]

Whats wrong with sublingual administration?

[MrKappa]

Specifically... I am concerned that I have a latent ear infection...

http://bjp.rcpsych.o.../193/3/192.full

Sure sure... cause and effect and co-incidence, however I'm interested in learning more about the differences, the specific differences, regarding blood brain barriers and ear administration.

When I was young, yeah, I had a massive ear ache, and I was asked to ingest anti-biotics, and I have to wonder why I didn't administer them through my ear.

[Epigenesis]

Specifically... I am concerned that I have a latent ear infection...

http://bjp.rcpsych.o.../193/3/192.full

Sure sure... cause and effect and co-incidence, however I'm interested in learning more about the differences, the specific differences, regarding blood brain barriers and ear administration.

When I was young, yeah, I had a massive ear ache, and I was asked to ingest anti-biotics, and I have to wonder why I didn't administer them through my ear.

I get ear infections a lot, I had three last year, the antibiotics never agree with my stomach, so I have also wondered why there isn't antibiotics for an ear infection that could administered through the ear. I am guessing it could cause a blockage or something, but maybe if it was in a solution which evaporates quickly it could work.

[jadamgo]

In general, drugs administered into the ear are only effective for conditions in the middle or outer ear, and only on that ear.

To bypass first-pass hepatic metabolism and deliver drugs straight into the bloodstream, sublingual or buccal administration works best. Intranasal and transdermal can be considered, but it's really not recommended unless the drug was designed to be administered that way.

None of these methods will affect blood-brain-barrier effectiveness. They only alter the absorption and metabolism of the drug. Whether or not it gets into the brain is based on the chemical properties of the drug itself, not the manner of administration.

[MrKappa]

Thanks. That sounds very reasonable.