http://www.plosmedic...al.pmed.1001606
Does anyone know why higher citrate levels can lead to higher all-cause mortality?
Also, would it maybe be useful to get blood tests for citrate and alpha-1-acid glycoprotein, even when one is young?
Posted 27 February 2014 - 02:44 AM
Posted 27 February 2014 - 06:41 PM
Citrate is an intermediate in the Krebs cycle and thus central to energy metabolism. Circulating citrate levels are tightly regulated, since citrate acts as a chelator to modulate calcium, magnesium, and zinc ion concentrations, and thereby exhibits anticoagulating properties [31]. ... Increased citrate was associated with increased risk of cardiovascular death as well as cancer death among participants in the Estonian Biobank cohort;
[31] Fraenkl SA, Muser J, Groell R, Reinhard G, Orgul S, et al. (2011) Plasma citrate levels as a potential biomarker for glaucoma. J Ocul Pharmacol Ther 27: 577–580. doi: 10.1089/jop.2011.0062
"In this masked study, plasma citrate levels were significantly decreased in Caucasian patients with glaucoma giving the possibility to use them eventually as a biomarker. "
Posted 27 February 2014 - 08:39 PM
Posted 27 February 2014 - 09:43 PM
Edited by xEva, 27 February 2014 - 09:45 PM.
0 members, 1 guests, 0 anonymous users