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Citrate levels and all cause-mortality?

citrate

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#1 InquilineKea

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Posted 27 February 2014 - 02:44 AM


http://www.plosmedic...al.pmed.1001606

Does anyone know why higher citrate levels can lead to higher all-cause mortality?

Also, would it maybe be useful to get blood tests for citrate and alpha-1-acid glycoprotein, even when one is young?

#2 xEva

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Posted 27 February 2014 - 06:41 PM

Here is what they say:

Citrate is an intermediate in the Krebs cycle and thus central to energy metabolism. Circulating citrate levels are tightly regulated, since citrate acts as a chelator to modulate calcium, magnesium, and zinc ion concentrations, and thereby exhibits anticoagulating properties [31]. ... Increased citrate was associated with increased risk of cardiovascular death as well as cancer death among participants in the Estonian Biobank cohort;

[31] Fraenkl SA, Muser J, Groell R, Reinhard G, Orgul S, et al. (2011) Plasma citrate levels as a potential biomarker for glaucoma. J Ocul Pharmacol Ther 27: 577–580. doi: 10.1089/jop.2011.0062

"In this masked study, plasma citrate levels were significantly decreased in Caucasian patients with glaucoma giving the possibility to use them eventually as a biomarker. "


Interesting that high citrate was associated with higher risk of death in the orig. study, while low citrate was associated with glaucoma in the study they reference.

I was trying to find the normal values for the 4 biomarkers, including citrate. Anyone knows them?

#3 niner

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Posted 27 February 2014 - 08:39 PM

I have a suspicion that these biomarkers are essentially markers of being sick. If you are sick, your odds of dying are generally higher. There is a pretty good chance that these biomarkers are just markers, but are not themselves causative of morbidity or mortality.

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#4 xEva

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Posted 27 February 2014 - 09:43 PM

:laugh: of course biomarkers are just indicators and not the cause of anything. But usually people get sick gradually, blaming it all on old age and not realizing how sick they actually got. Sort of like that frog in a warming pot that relaxes in warm water and does not jump out in time -- until it's too late.

I would expect these biomarkers to provide an estimate how much longer a person got, be it oneself or a relative. ..and signal that it's time to jump out or else.

Edited by xEva, 27 February 2014 - 09:45 PM.






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