5 replies to this topic

[VP.]

"Here, we show for the first time that a synthetic SIRT1 activator extends lifespan and improves healthspan of mice fed a standard diet,"
http://www.naturewor...ds-lifespan.htm

"In the study, the rodents were fed 100 mg/kg SRT1720 along with a standard diet."

Edited by velopismo, 02 March 2014 - 04:41 PM.

[malbecman]

Nice find, thanks for posting.

[APBT]

FULL TEXT: http://www.sciencedi...4714000655?cc=y
Summary
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD⁺-dependent deacetylase, improves metabolism and confers protection against physiological and cognitive disturbances in old age. SRT1720 is a specific SIRT1 activator that has health and lifespan benefits in adult mice fed a high-fat diet. We found extension in lifespan, delayed onset of age-related metabolic diseases, and improved general health in mice fed a standard diet after SRT1720 supplementation. Inhibition of proinflammatory gene expression in both liver and muscle of SRT1720-treated animals was noted. SRT1720 lowered the phosphorylation of NF-κB pathway regulators in vitro only when SIRT1 was functionally present. Combined with our previous work, the current study further supports the beneficial effects of SRT1720 on health across the lifespan in mice.

[niner]

Considering how potent a SIRT1 activator SRT1720 was supposed to be, they sure fed a lot of it to these mice. 100mg/kg sounds like a dose that would be appropriate for a natural product like resveratrol. I'd expect a highly engineered compound to exhibit more potency than that. Was this just an OD because they wanted to be sure they got a result, or did they do a dose-ranging study to see what was needed?

[nootropicsandsarms]

here a source of buy srt1720 : http://www.acrosebio...show.asp?id=188

and resveratrol (natrual extact):50%.with Emodin 3%min,50% withEmodin 2%max;55%,98%,99%(400usd/kg) in stock

Edited by nootropicsandsarms, 30 March 2014 - 12:52 PM.

[fairy]

Unfortunately SRT1720 does not extend maximum lifespan, still doing a good job with it's mean value.