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Acute Nerve Damage? Please Help Prevent Chronic Pain

nerve

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#1 typo MyUsername

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Posted 07 March 2014 - 09:18 PM


Salutations everyone,

I am a long time lurker. I suppose it is too bad that my first post is as follows. I am afraid that I damaged the nerves in my big toe. Two nights ago (3/5/14) I used Aniracetam and Ephedrine to stay awake all night and complete university assignments that were due the following morning. The last two paragraphs are the most important if you do not want to read everything

At one point I stood up and after taking a few steps noticed a pain in my big toe. At first I thought I had been stung by something. I continued to work and limp on that foot. I am worried that when I was sitting on my legs for an extended amount of time, Aniracetam modified the response when my foot 'fell asleep', because the pain has not stopped and I can feel tingles on my toe when pressure is applied in certain places, such as sitting indian style. The shooting pain still exist during the second part of taking a step on that foot (the part where you bend your toes and move the other foot forward) It is a very strong pain and I have had to not bend my foot as I walk.

Playing with my foot right now, it seems a lot of this pain originates when pressure is applied to the right side of this toe. This is the part facing my other foot, not between my toes. It seems when I take a step I can see that pressure gets applied at that area, and from there lots of sensations occur that should not. In fact, the more I mess with it, I realize it is this area, as putting even a little pressure on it causes me to flinch in pain. A small amount of pressure seems to penetrate the entire toe.

I feel as though I am losing much of my diginity, but here is what I took:
7pm - 900mg EPA/DHA/DPA, 667% RDA vit E complex (high in gamma isomer), 100mg CoQ10
12am - 100mg r-lipoic acid on an empty stomach
12:30am - 6.25mg Ephedrine/100mg Caffeine/750mg Aniracetam/???sublingal methylB12/Gingko + Gensing
1:30am - 6.25mg Ephedrine/50mg Caffeine/400mg Magnesium (from malate)/1.15mg sublingual rosveratrol
3:00am 100mg r-lipoic acid
4:00am 6.25mg Ephedrine/400 mg Magnesium/500mg VitC (with bioflavaniods so tasty!) PAIN STARTED HERE
7am 100mg r-lipoic acid/6.25mg Ephedrine
2pm - 200mg r-lipoic acid
3pm - .5g VitC + magnesium
5pm - VitA + 900mg EPA/DHA/DPA (Maybe a VitE complex that also has fat soluble C and racemic lipoic I cannot remember if I took it or not)
7pm - 200-600 mcg Melatonin + 500mg Theanine + Epsom Salt bath (Magnesium Sulfate) one pound on my body and let it sit while wet for a long time before letting the water rise. A lot on my foot =)
10pm - sleep, I felt so relaxed it took a while to fall alseep if that makes any sense.

I listed everything in case somebody can spot something that should not have been mixed. The only new thing was the rosveratrol and Gingko/Gensing at the same time. Only used CoQ10 a few times and I feel it does more harm that good.

As we know Aniracetam changes responses to oxygen deprivation and LTP. Studies suggest blockade of NR2B subtype of NMDA receptors can prevent nerve pain from becoming chronic. This is interesting because tinnitus has been a problem for me and I am very sensitive to it. I have found that high does NMDA antagonism can stop a tinnitus from becoming chronic if administered close enough to onset. In fact, there are studies that demonstrate this too!

I might can get my hands on some ketamine and of course I can get some DxM. I want to know how I can reduse any possible neurotoxicity of these compounds without reducing the power of their NMDA antagonism. I have had tinnitus for a long time now. I do not want to look back and regret not having taken dxm or K because I cannot walk for the rest of my life. For tinnitus it was found that it must be administered within 4-5 days of onset, and this seems to support my first hand experience. But for nerve injuries I cannot seem to find a time period.

All input is appreciated, as the clock is ticking. Lets hope this is just a spider bite that is not showing any swelling! For now I am very hungry and will check back when I am done eating.

#2 typo MyUsername

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Posted 08 March 2014 - 09:51 AM

If a moderator would like to move this thread in order to get better responses that would be appreciated. Maybe I should have posted in brain or supps. Nonetheless, it seems I will be taking some diphenhydramine with my poison because Ach antagonist prevent NMDA exitotoxicity. And yes, you read that correct. By inhibiting the NMDA channel it is though to also inhibit inhibition for certain cells. It appears GABA agonist or allosteric modulators would be of use too. If anyone could recommend one that is not alcohol and OTC that would be awesome. But I highly doubt such a thing exist :] Phenibut and Picomilon are on hand. Direct agonist like Valarian may not work well methinks. But doesn't Phenibut decrease seizure threshold?

I just can't see how I could have caused a bruise this deep without any blackening or swelling as that is what it feels like now. Although tingling shooting pains still happen occasionally. Not to mention I was sitting down! I'll try to keep the thread updated. Lets just hope it was not hypoxia at my feet.

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