• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo

What is the mechanism for cholesterol metabolism as it pertains to the ApoE alleles?

cholesterol atherosclerosis apoe

  • Please log in to reply
2 replies to this topic

#1 ShrewdSimian

  • Guest
  • 9 posts
  • 8
  • Location:East Coast U.S.
  • NO

Posted 08 March 2014 - 08:42 PM


I recently found out I have the ApoE E3/E4 allele. My overall combined LDL cholesterol is presently abnormally high (176 mg/dL), which is the only thing "high risk" in my results. I'm wondering what the actual mechanism is for the function of this gene and how to attenuate its function. I've really been digging but can't seem to find a good explanation of how it really functions on a root level to process cholesterol in the liver.

Attached is my happy little SpectraCell LPP graph of my results after being on a hybridized paleo/primal/slow carb/keto diet for about 6 months.

I feel absolutely fantastic on the diet and have more energy, better overall health and clearer headedness that at any point in my past. I'm more than a little bothered by the current research that points to a high fat diet being potentially pathological to the presence of an ApoE4 variant, especially considering I feel like crap when eating a high carb low fat diet.

Yes, the possibility for AD does present a concern to me with this gene, but much less so than CHD/CAD given the men who have suffered from heart disease in my family.

So far my only lead in reducing the presence of ApoB-100 (114 mg/dL) in the blood has been supplementation with berberine. 1, 2 I have yet to find the optimal berberine dosage.

Attached Files


Edited by ShrewdSimian, 08 March 2014 - 08:45 PM.


#2 Bonee

  • Guest
  • 147 posts
  • 61
  • Location:Budapest

Posted 10 March 2014 - 10:03 AM

I think this Entrez entry summarises the fuction of apoE very well

"Entrez Gene summary for APOE Gene: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. (provided by RefSeq, Jul 2008)

so you got a high level of ldl because your body got a hard time removing your isoform of apoE from the blood because it's got a lower affinity for the receptors.

On the therapy side, I am a big fan of high dose niacin 1000-2000 mg / day because it raises hdl (and lowers triglycerides and ldl) and the hdl is which can remove the plaques.

sponsored ad

  • Advert
Click HERE to rent this MEDICINES advertising spot to support LongeCity (this will replace the google ad above).

#3 ShrewdSimian

  • Topic Starter
  • Guest
  • 9 posts
  • 8
  • Location:East Coast U.S.
  • NO

Posted 11 March 2014 - 07:26 PM

Thanks for the data and analysis. Helps point me in the right direction for my plan of action. :)





Also tagged with one or more of these keywords: cholesterol, atherosclerosis, apoe

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users