I recently found out I have the ApoE E3/E4 allele. My overall combined LDL cholesterol is presently abnormally high (176 mg/dL), which is the only thing "high risk" in my results. I'm wondering what the actual mechanism is for the function of this gene and how to attenuate its function. I've really been digging but can't seem to find a good explanation of how it really functions on a root level to process cholesterol in the liver.
Attached is my happy little SpectraCell LPP graph of my results after being on a hybridized paleo/primal/slow carb/keto diet for about 6 months.
I feel absolutely fantastic on the diet and have more energy, better overall health and clearer headedness that at any point in my past. I'm more than a little bothered by the current research that points to a high fat diet being potentially pathological to the presence of an ApoE4 variant, especially considering I feel like crap when eating a high carb low fat diet.
Yes, the possibility for AD does present a concern to me with this gene, but much less so than CHD/CAD given the men who have suffered from heart disease in my family.
So far my only lead in reducing the presence of ApoB-100 (114 mg/dL) in the blood has been supplementation with berberine. 1, 2 I have yet to find the optimal berberine dosage.
Attached Files
Edited by ShrewdSimian, 08 March 2014 - 08:45 PM.