Ahhh. Taken from:
http://examine.com/s...ensis/#summary5 5. Interactions with Glucose Metabolism 5.1. MechanismsDue to the ability of both Wogonin
[38] and Baicalin
[33] (as well as the whole plant extract
[39]) to activate AMPK,
scutellaria baicalensis has some evidence investigating its interactions with glucose metabolism. This is since AMPK activation is inhernetly hypoglycemic
[30] and the molecular target of many anti-diabetic compounds (Metformin and
Berberine in particular).
Scutellaria baicalensis may have anti-diabetic properties due to its ability to activate AMPK
5.2. Blood GlucoseIn studies of diabetic mice, 10-100mg/kg of the plant extract (11.02% baicalin, 1.40% baicalein, and 0.39% wogonin) has been found to dose-dependently reduce circulating insulin concentrations over four weeks
[39] which has been replicated with 400mg/kg of the plant over the same timeframe with a potency nonsignificantly greater than 500mg/kg metformin.
[86]50mg/kg of
scutellaria baicalensis (20.46% baicalin, 0.93% baicalein, and 0.33% wogonin) or 5mg/kg of isolated baicalin have elsewhere failed to reduce blood glucose in diabetic rats
[87] although 400mg/kg appears to be as effective as the reference drug (500mg/kg metformin).
[86]This plant may reduce blood glucose, although it appears to require a few weeks to be effective. It seems to be more effective in reducing insulin than in reducing glucose