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the elusive choline sweet spot

piracetam aniracetam noopept brain damage marijuana creative perfect

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#1 Guest_Funiture2_*

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Posted 18 March 2014 - 03:26 PM


I find it incredibly difficult to pinpoint my exact needs. The trouble I run into is that CDP choline has a short half life which requires continual dosing. It seems that I can easily overdo my choline supps easily resulting in a depressed mood, introversion, stiff neck and what not. But I can also easily underdo my choline which means my stack stops working. My normal state is depressed so its a bit difficult to decipher when I need more or less. Do true choline sources like CDP, bitartrate, Alpha GPC, and Lecithin need to be supplemented with a 1:1 ratio of an Acetyl group donating supplement like ALCAR or NAC? Many people have success with just one or the other, but wouldn't in theory we would require both in equal amounts for acetylcholine formation?

I need to know if anyone has had experience with some other choline similar supplement (like DMAE, centrophenoxine, Huperzine A, etc) that has helped them find their choline sweet spot. There's a thin line for me between too much and too little, and I feel whiplashed going from bad to good to bad again, so is there a compound/drug combo/supplement that will help prevent choline overload while maintaining a healthy level?

It would also be helpful to go into the mechanisms of such a drug not just personal experiences (although that is very helpful too).

#2 ron45

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Posted 18 March 2014 - 11:14 PM

Hello oner, I'm unsure if nootropic compounds are good for depression. I'm not educated in medicine. But perhaps you could look into lecithin granules. They should take longer to get into your system. By itself I don't know if lecithin has everything needed to support pirasetam's actions in our brain. I'm very new to nootropics and am reading what I can find on the subject and you can not believe every thing you read on line. Most MDs know nothing about this field. There is a chemist active over at: http://ceri.com/index.htm... but if he is still claiming to cure Alzheimer's and herpes I wouldn't place a lot of stock in everything he says. The was a very unprofessional thing to allege.

This is a fairly new field, you could say… the wild west of brain food. The wild west was a magnet for…… the kindest thing I could say is nefarious speculators from the shallow end of the gene pool This field is not too different. Everyone you meet is selling the perfect snake oil. There are also sincere adventurers who are finding their was thru a very complex topic and who in some cases stand behind their product. But how to separate the wheat from the chaff is the question.

The only thing we can and must, do is try to verify what we read. That is not easy and time consuming. The best solution if you have the right kind of insurance is to go to an alternative medicine Dr.with a brick and mortar building whose face you can look into while you get their pitch. In the absence of personal experience it is tough. Hopefully this forum and others like it should have some non trollers who have been using some of these products and will share their experience.

Remember everyone is a biochemical individual. What works for me might do nothing or even harm you.

It occurred to me that inositol is part of what helps choline to get used. Possibly some searches with choline and timed release or long acting may be of help. Tho it's tough to verify if someone's alleged timed release is working properly.

I can say my experience while short, is positive so far with using vinpocitine, piracetam, Choline Citicoline. in fairly conservative doses. Ran into so some sleaze when I bought the vinpocitine, I'd didn't look at the size of the dose on the bottle. I think most people taking nootropics would agree that 5mg is something less than ideal. Swanson has it cheaper in larger doses. 30 mg. They seem to be a pretty good company to deal with. I hope you get some better answers then mine. Might try the Drug Forum, they probably have the most active nootropics forum. There seem to be active chemists there. Some of the posts are pretty scholarly.

I told the moderators they spent too much time IN MY FACE with large black and yellow popups every time I changed screens where they were begging for money. All the while saying we are commercial free. I can't be the only one who sees the lie in that.

Their response was to banish me for all eternity. They sure don't want that sort of information spreading around. Those people seem to be suffering from delusions of adequacy. Most people have the good taste to simply state they accept donations somewhere on a page even each page. These folks go at it like third world am radio. I will admit I am sensitive to marketing, allergic might be more descriptive.

Thank you for pointing out that choline doesn't hang around long. I will look into that too. See ya when I find something and the very best luck in finding a solution.

Ron
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#3 Guest_Funiture2_*

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Posted 16 April 2014 - 10:38 PM

I'm researching sublingual Uridine as well as DMAE as effective methods to control choline spikes and drops which I have trouble with.



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#4 chris106

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Posted 13 May 2014 - 07:54 AM

I'm researching sublingual Uridine as well as DMAE as effective methods to control choline spikes and drops which I have trouble with.

 

This is very inetersting, Oner. I have high Acetylcholine symptoms from constant Modafinil use. While modafinil doesn't directly influence ACh levels, I suspect it indirectly raises it through elevated Glutamate over time.

 

I tried 1st gen antihistamines, but they also cancel out the positives from Modafinil...

Have you had any success in treating high ACh symptoms with Uridine and/or DMAE yet?







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