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Unifiram: The Unsung Hero

unifiram ampakines ampakine ampa modulation

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39 replies to this topic

#31 WillHen

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Posted 28 June 2014 - 10:27 AM

Hi Kassem,
Thanks for your great post!

"a meditative state of mind" is exactly what i'm looking for.

I have intrusive and obsessive thoughts, rarely compulsive.
Coluracetam helps my anxiety and impulse control, can't wait to add unifiram soon.

#32 mait

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Posted 28 June 2014 - 11:18 AM

Sorry to crash the party but I trailed Unifiram 2 months ago with not so impressive results. Described meditative and "deep thinking philosophical" state was there but my subjectively assessed working memory performance (reading and writing span) and productivity fell a significant degree. The days went by effortlessly, and sadly unproductively, while using Unifiram. I wrote a term paper while on unifiram (10-20 mg) and it was subjectively one of my worst writings I have done and handed in during my university studies.

 

The first confounding variable may have been high work load and stress at that time. Still I have written term papers under similar conditions before with much better end results. The second confounding variable may have been my general habit of getting things done by virtue of negative motivation. I mean my work and effort is mostly directed by fear of punishment or bad feedback because of missed deadline. Unifiram completely abolished this “negative motivational anxiety”, which in turn may have had role in subpar performance if compared to my usual standards.

 


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#33 OpaqueMind

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Posted 28 June 2014 - 01:22 PM

"a meditative state of mind" is exactly what i'm looking for.

I have intrusive and obsessive thoughts, rarely compulsive.

 

Have you tried... meditation?  :-D Seriously though, this is exactly what you need. If you don't have the will or your mind is so chaotic it takes you ages to get anywhere, consider Theta-alpha-gamma synchrony neurofeedback training, which is like meditation injected with rocket fuel ie it will get you much further, much faster.

 

Obsessive thoughts is a systems level issue, which cannot be solved pharmacologically (although the symptoms can be temporarily remediated this way, but not without side-effects).

 

Edit; The 2nd part of this post I wrote yesterday should help you understand a) what, at a broad systems level, is causing your obsessive thoughts and b) why pharmaceuticals are ineffective at fixing this.


Edited by OpaqueMind, 28 June 2014 - 02:07 PM.


#34 WillHen

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Posted 28 June 2014 - 10:30 PM

Thanks Mait and OpaqueMind

Haha..yes,i have chaotic mind indeed!

I've tried binaural/isochronic tones, it worked but yes i didn't have a strong will to use it continously.

LLLT is interisting, i will read more about it, thank you.

#35 8bitmore

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Posted 29 June 2014 - 04:14 PM

Update on my Unifiram experience, started being on/off, despite taking intermittently. Even a one time dose of 50mg in capsule failed to give any obvious effect, maybe its too subtle, maybe its not there - the main point is that Unifiram is no 'miracle' molecule for me but rather like so many other drugs, good at times and ineffectual at others. I can second the meditation recommendation, the basics work and they work well, I've yet too see any of the nootropics come close to the effects of having sustained meditation practise (it might also simply be that the fact that I do is overlapping/already-covering some/most of the areas that people see improvements in when they take nootropics.. I digress).



#36 thereisway

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Posted 26 July 2014 - 09:19 PM

Hi Kassem,
Thanks for your great post!

"a meditative state of mind" is exactly what i'm looking for.

I have intrusive and obsessive thoughts, rarely compulsive.
Coluracetam helps my anxiety and impulse control, can't wait to add unifiram soon.

 

Hey did you try that combo. am very interested to hear your results



#37 thereisway

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Posted 27 July 2014 - 07:35 AM

 

Thanks for your detailed reply kassem23. From what you describe, it sounds like Unifiram may be preferable over Sunifiram in individuals prone to anxiety. That anti-fatigue effect is also interesting.
I think I will order some soon, along with Oxiracetam, from NSN. If my findings are anywhere near as noteworthy as yours, I'll be sure to post them here.



BTW. Unifiram combines extremely well with oxiracetam, so that's a great choice.

 

 

I know youve mentioned somewhere that it would not be wise to combine sunifiram with modafinil.... What abt Unifiram with modafinil?



#38 NyteFox

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Posted 08 January 2016 - 08:40 PM

My fiancé showed me this article. So far, Unifiram sounds like an amazing nootropic. As a semi-newbie to nootropics, I'm definitely going to try this out as soon as he buys some.

As for the others you mentioned, he's talked about those too. I can't wait to try all of them out and see how they'll affect my brain.

I'm looking forward to fixing the damage that my past prescription drugs and recreational use of Adderall has done to me, as well as other things. I'm glad I got to read this post.

#39 linlin92

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Posted 08 November 2016 - 10:03 AM

I have now joinged the Unifram club, after reading as much as I could about it on here and reddit. I also has sunifram as well but won't be touching that because I am spooked by some of the experiences I have read.

 

But since I started memantine a few days ago (still titrating up), I find the tiniest amount of unifram makes a noticeable difference to hand eye coordination, overall cognition and mental sharpness. It also improves my baseline mood more than memantine alone so I can't complain about that!

 

ROA is 3mg sublingually chased down with a teaspoon or so of choline bitartrate (so I can let the body grab as much choline as it needs rather than 'forcefeed' it into the brain like with CDP-Choline). The first time I just ate eggs for breakfast for my choline source and still got headaches from it but the bitartrate solved that problem within an hour.

 

So.. Colours are more interesting (my car's interior lights now look like a neon show at times!) and music even from a crappy radio sounds like I am at the main stage of Ultra Music fetival :laugh:


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#40 Zed

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Posted 02 December 2017 - 07:08 AM

I have now joinged the Unifram club, after reading as much as I could about it on here and reddit. I also has sunifram as well but won't be touching that because I am spooked by some of the experiences I have read.

 

But since I started memantine a few days ago (still titrating up), I find the tiniest amount of unifram makes a noticeable difference to hand eye coordination, overall cognition and mental sharpness. It also improves my baseline mood more than memantine alone so I can't complain about that!

 

ROA is 3mg sublingually chased down with a teaspoon or so of choline bitartrate (so I can let the body grab as much choline as it needs rather than 'forcefeed' it into the brain like with CDP-Choline). The first time I just ate eggs for breakfast for my choline source and still got headaches from it but the bitartrate solved that problem within an hour.

 

So.. Colours are more interesting (my car's interior lights now look like a neon show at times!) and music even from a crappy radio sounds like I am at the main stage of Ultra Music fetival :laugh:

 

Any feedback on usage? I am interested in your stacking unifiram with memantine. Given the literature indicates that unifiram reverses the effects of NMDA antagonism it is interesting to see you getting a synergistic effect from stacking them together. I wonder if you are still taking these and whether you tried staggering them ..is taking the unifiram some hours after or before the memantine? 
 







Also tagged with one or more of these keywords: unifiram, ampakines, ampakine, ampa, modulation

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