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Comparison of L-Tyrosine VS Sulbutiamine subjective effects

sulbutiamine l-tyrosine dopamine

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#1 BlueCloud

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Posted 29 March 2014 - 10:36 PM


I've been taking both of these on and off for some time, and while they are often cited in the same breath when mentionning supplements with pro-dopaminergic effects, I find they have as many things in common as they have subtle differences.

Their mechanisms of action is already discusses in various thread , but suffice to say that L-Tyrosine delivers the basic building block (Tyrosine) for the brain to convert into Dopamine , then later into Norepinephrine, where Sulbutiamine is more complex and not entirely understood, as it is mainly a form of Vitamin B1 ( thiamine ) that crosses the blood-barrier, but has all sorts of weird effects such as lowering dopamine while increasing dopamine receptors density.

There are already some good discussions about Sulbutiamine , like this one , and about Tyrosine like this one ( and many others once you do a search ). But this thread is to highlight subjective common points as well as differences.

Effects they both have in common :

- Feeling of sustained mental energy : being able to sustain mental work longer through the day, with more depth , less fatigue. Sulbutiamine has the edge over Tyrosine however, I get sustained mental energy that last much longer thru the day than Tyrosine, the latter still leaves me tired at the end of the day, in a natural way and perhaps a healthier way ( we're not supposed to be running on and on like Energizer bunnies ). Wich leaves me to think that Sulbutiamine should be used more sporadically than Tyrosine. And because of that I've never been able to take Sulb more than a few days in a row without a longer break, since that lingering energy worsens my already bad insomnia.

- Better Focus : Both do enhance capacity for concentration, better focus, lessening of ADHD. Sulbutiamine brings a sort of sharper, laser-like focus, while Tyrosine's focus is a bit more natural.

- Slightly enhanced libido : Both seemed to enhance desire and interest in sex, but not in a dramatic way.

Effects that are quite unique to each one :

- Sulbutiamine

* Pro-social effect : I don't get this with Tyrosine. I'm quite introverted and have some Social Phobia. On Sulbutiamine I surprised myself ,on many occasions, spontaneously talking to strangers, bouncing off their jokes, etc.. It happens in a natural way, and I often only notice afterwards ( " Wow, did I really just do/say that ?"). Conversations seems more fluid, words come more easily without too much thought beforehand.

- L-Tyrosine

* Decision Taking and Motivation : Strangely enough, I don't really feel that my motivation is increasing so much on Sulbutiamine. I still find myself procrastinating very often on a lot of things. Whereis on Tyrosine , a most striking difference is the much enhanced facility to MAKE DECISIONS. And taking decisions is the crux of procrastination. I procrastinate a lot, wich means that I linger into weighting the pros and cons of many actions , constantly postpone the decision, often because I feel that I need even more "pros VS cons" evaluations before deciding on a direction, and just don't feel strongly the neeed to end this process or to close the file..
On L-Tyrosine, what changes is the WILL TO MAKE A DECISION. Not that it makes me more impulsive; I still carefully weigh the pros and cons before deciding. However there is now a strong desire to bring the process of evaluation to an end, to close the open loops, to take a decision, a firm direction; close the file and move on to other things.


* Feelings of anger : It doesn't happen often, ( and rarely on Sulbutiamine ), but I sometimes get this low-intensity form of anger, of being pissed-off, that lingers in the background. This may be due to the Dopamine being converted into Norepinephrine ( SNRIs for example often make me very angry ). This can be as much a negative side-effect as a positive one. As long as the anger is not overwhelming, it can be additional source of energy to solve issues left unsolved, to move projects forward, to not settle on the Status-Quo.
On some occasions however, it can be overwhelming and end up being unproductive.

Edited by BlueCloud, 29 March 2014 - 10:37 PM.


#2 pbandy1

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Posted 30 March 2014 - 01:35 AM

Thanks for your thoughts. Both are good for me but have yet to try them both concurrently throughout the day. I will say that while tyrosine is a nice thing to take upon waking to get the day started, I prefer sulbutiamine as a pre-workout (Neurodrive or Biotest Spike).

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