659 replies to this topic

[Helllllo]

Could I get the 100mg for 100 US as I'm quite low on funds but am also desperate. Can transfer the money asap just let me know please.

[Helllllo]

Or if anyone wants to go halves on their 250mg, holla.

[Reformed-Redan]

Still some spots open for 500 mg. Last chance. 

 

Cheers.

[Bukujutsu]

I could definitely split 250mg with someone reputable after they receive it, if anyone's interested.

[lambda]

250mg here.

[lambda]

Still some spots open for 500 mg. Last chance. 

 

Cheers.

 

I'm in for 500mg. I can't send you more PMs.

[Reformed-Redan]

 

Still some spots open for 500 mg. Last chance. 

 

Cheers.

 

I'm in for 500mg. I can't send you more PMs.

 

Got you.

[samson75]

Hello Redan, did you got my order ?

[Reformed-Redan]

Hello Redan, did you got my order ?

I'm pretty sure Nick got it. If you want confirmation PM him with your transaction number. 

 

Cheers.

[dankis]

So how long to, or how much $ before we can start synthesis?

Regards

[Reformed-Redan]

So how long to, or how much $ before we can start synthesis?

Regards

As far as I know, the synthesis has already begun. Either that or Nick is closing the final details with the Polish lab. 

 

Cheers.

[Reformed-Redan]

There are still some 500 mg spots left if anyone is interested.

[Milkyway11]

OK so how do I request 250mg of NRX 1074?

[opusensemble]

@Milkyway11 or someone interested. I'm stepping out of this group buy.
I'm selling my 250mg spot for $207.5 (which was how much I negotiated with redan, to include shipping). Contact me for Paypal payment details.
Once paid I'll need to update redan about the new shipping address: now your address. 
I'll sell it to the first person contacting me. 

Edited by opusensemble, 02 May 2016 - 08:00 PM.

[MoreNowAgain]

@Milkyway11 or someone interested. I'm stepping out of this group buy.
I'm selling my 250mg spot for $207.5 (which was how much I negotiated with redan, to include shipping). Contact me for Paypal payment details.
Once paid I'll need to update redan about the new shipping address: now your address. 
I'll sell it to the first person contacting me. 

Is there a certain reason why you decided to step out? Just genuinely curious.

[opusensemble]

 

@Milkyway11 or someone interested. I'm stepping out of this group buy.
I'm selling my 250mg spot for $207.5 (which was how much I negotiated with redan, to include shipping). Contact me for Paypal payment details.
Once paid I'll need to update redan about the new shipping address: now your address. 
I'll sell it to the first person contacting me. 

Is there a certain reason why you decided to step out? Just genuinely curious.

 

No special reason, just decided to postpone my NRX-1074 trial and extend my drug washout period.
Releasing my 250mg spot to anyone interested. 


 

[franbird]

Why would you have to pay more than $200 for 250mg shipped? Wasn't that the stated price in this thread by Nick and redan?

[Nick Kyz]

2 packages are more expensive than 1. Average shipping cost will be about $15+. Priority shipping, insurance, labor/materials. These have costs.

 

I'm about to close the deal with the laboratory. I'm following up with a few of their client references (you can't be too safe). And based on those calls I will send the money.

[opusensemble]

Why would you have to pay more than $200 for 250mg shipped? Wasn't that the stated price in this thread by Nick and redan?

Nick just answered your question. 

[foreseason]

I'm late to this party. any spots still available?

[Reformed-Redan]

I'm late to this party. any spots still available?

Some 500 mg spots open.

 

400 USD buys you 500 mg of NRX-1074.

[stillwater]

I am interested in a $100 position if it's still available.

 

[Kulcan]

I'd be interested in 100mg for 100usd as well if its still available

[foreseason]

Hmmm. Not sure I'm $400 interested. On the fence

[GreenWhite]

Someone from germany interested in sharing 500mg?

 

If i don't find someone to share i'll take the 500 by myself. Would be nice if some could give a quick tutorial on how to turn NRX into a nasal spray

[Nick Kyz]

MA wrote a good post on making your own nasal sprays: http://www.metabolic...l-selank-spray/

 

Edit: Oh the curse of terminable online media. The website is relaunching, I'm not sure if it will even have the same URL afterwards. Suffice it to say it's easy to do and one of us can write a guide when the time comes.

 

Edited by Nick Kyz, 04 May 2016 - 11:31 PM.

[Reformed-Redan]

MA wrote a good post on making your own nasal sprays: http://www.metabolic...l-selank-spray/

 

Edit: Oh the curse of terminable online media. The website is relaunching, I'm not sure if it will even have the same URL afterwards. Suffice it to say it's easy to do and one of us can write a guide when the time comes.

One thing that concerns me is if the product will dissolve in aq. solutions? Could you ask the Polish lab what they think?

 

Best regards.

[The Capybara]

I had posted a few pages back that I would order some bulk Radix Polygalae extract based on the posting below.

It has arrived and if anyone wants some, just message me.

I'm not trying to redirect any NRX topics, but this was a short discussion within this thread previously and I'm just following up.

They are 100g bulk sealed aluminized bags. Non-irradiated and from one of my steady, reliable and trustworthy Chinese sources.

I included this one in my last bulk order which just arrived and this was based on "opusensemble's" posting.

How's $20 including shipping within the US (for Longecity people only)?

Now back to our regular programming......

 

I have recently placed a post, while looking for an alleged "Ketamine cousin" from nature from a 2013 research from South Korea: 

http://www.longecity...on/#entry765325
 

Radix Polygalae

Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract. (2014 study)
http://www.ncbi.nlm....pubmed/24520403
http://journals.plos...al.pone.0088617

 

At least that research paper concludes on Radix Polygalae, the root from polygala tenuifolia (a.k.a. yuan zhi -> Chinese: 遠志), the following: 

 

"RP may possibly substitute for other rapid-onset antidepressants like ketamine that are associated with addiction risk and unacceptable side effects. It will be worthy to further evaluate the pharmacologic effects of RP and especially its constituent parts as candidates for novel antidepressant development."

As counter-argument: There is actually a study on the same herb identifying 6 saponin molecules (YuanZhi-1 to YuanZhi-6, 4 of them with antidepressant potential)
http://www.sciencedi...278584614000438
http://sci-hub.io/10...880200903280034
Being hormones, is not very attractive due to the problems they can induce in hormonal systems. Also, they are shown in the study to have anti-depressive potential through affinity to monoamines (SERT, DAT, NET), which gets it on the same realm as SSRIs/SNRIs and TCAs. So, RP gets a bit discouraging there, despite other article from 2015 mentioning the potential of saponins in addressing depression: 

Saponins: the phytochemical with an emerging potential for curing clinical depression. (<- the word "curing" was probably used irresponsibly or lost in translation)

http://www.ncbi.nlm....pubmed/25075957

http://sci-hub.io/10...419.2014.942661

 

 

[Reformed-Redan]

 

I had posted a few pages back that I would order some bulk Radix Polygalae extract based on the posting below.

It has arrived and if anyone wants some, just message me.

I'm not trying to redirect any NRX topics, but this was a short discussion within this thread previously and I'm just following up.

They are 100g bulk sealed aluminized bags. Non-irradiated and from one of my steady, reliable and trustworthy Chinese sources.

I included this one in my last bulk order which just arrived and this was based on "opusensemble's" posting.

How's $20 including shipping within the US (for Longecity people only)?

Now back to our regular programming......

 

I have recently placed a post, while looking for an alleged "Ketamine cousin" from nature from a 2013 research from South Korea: 

http://www.longecity...on/#entry765325
 

Radix Polygalae

Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract. (2014 study)
http://www.ncbi.nlm....pubmed/24520403
http://journals.plos...al.pone.0088617

 

At least that research paper concludes on Radix Polygalae, the root from polygala tenuifolia (a.k.a. yuan zhi -> Chinese: 遠志), the following: 

 

"RP may possibly substitute for other rapid-onset antidepressants like ketamine that are associated with addiction risk and unacceptable side effects. It will be worthy to further evaluate the pharmacologic effects of RP and especially its constituent parts as candidates for novel antidepressant development."

As counter-argument: There is actually a study on the same herb identifying 6 saponin molecules (YuanZhi-1 to YuanZhi-6, 4 of them with antidepressant potential)
http://www.sciencedi...278584614000438
http://sci-hub.io/10...880200903280034
Being hormones, is not very attractive due to the problems they can induce in hormonal systems. Also, they are shown in the study to have anti-depressive potential through affinity to monoamines (SERT, DAT, NET), which gets it on the same realm as SSRIs/SNRIs and TCAs. So, RP gets a bit discouraging there, despite other article from 2015 mentioning the potential of saponins in addressing depression: 

Saponins: the phytochemical with an emerging potential for curing clinical depression. (<- the word "curing" was probably used irresponsibly or lost in translation)

http://www.ncbi.nlm....pubmed/25075957

http://sci-hub.io/10...419.2014.942661

 

 

Sure, sounds like a steal. 

[MoreNowAgain]

 

I had posted a few pages back that I would order some bulk Radix Polygalae extract based on the posting below.

It has arrived and if anyone wants some, just message me.

I'm not trying to redirect any NRX topics, but this was a short discussion within this thread previously and I'm just following up.

They are 100g bulk sealed aluminized bags. Non-irradiated and from one of my steady, reliable and trustworthy Chinese sources.

I included this one in my last bulk order which just arrived and this was based on "opusensemble's" posting.

How's $20 including shipping within the US (for Longecity people only)?

Now back to our regular programming......

 

I have recently placed a post, while looking for an alleged "Ketamine cousin" from nature from a 2013 research from South Korea: 

http://www.longecity...on/#entry765325
 

Radix Polygalae

Preclinical evidence of rapid-onset antidepressant-like effect in Radix Polygalae extract. (2014 study)
http://www.ncbi.nlm....pubmed/24520403
http://journals.plos...al.pone.0088617

 

At least that research paper concludes on Radix Polygalae, the root from polygala tenuifolia (a.k.a. yuan zhi -> Chinese: 遠志), the following: 

 

"RP may possibly substitute for other rapid-onset antidepressants like ketamine that are associated with addiction risk and unacceptable side effects. It will be worthy to further evaluate the pharmacologic effects of RP and especially its constituent parts as candidates for novel antidepressant development."

As counter-argument: There is actually a study on the same herb identifying 6 saponin molecules (YuanZhi-1 to YuanZhi-6, 4 of them with antidepressant potential)
http://www.sciencedi...278584614000438
http://sci-hub.io/10...880200903280034
Being hormones, is not very attractive due to the problems they can induce in hormonal systems. Also, they are shown in the study to have anti-depressive potential through affinity to monoamines (SERT, DAT, NET), which gets it on the same realm as SSRIs/SNRIs and TCAs. So, RP gets a bit discouraging there, despite other article from 2015 mentioning the potential of saponins in addressing depression: 

Saponins: the phytochemical with an emerging potential for curing clinical depression. (<- the word "curing" was probably used irresponsibly or lost in translation)

http://www.ncbi.nlm....pubmed/25075957

http://sci-hub.io/10...419.2014.942661

 

 

 

There's another more studied TCM alternative to ketamine with ketamine-like mechanisms that you can look into as well. Yeu Ju Wan (Escape Restraint Pill).

 

http://www.ncbi.nlm....les/PMC4551989/

 

​Yueju, a Traditional Chinese Medicine formula, exhibited fast-onset antidepressant responses similar to ketamine. This study focused on assessing the rapid and persistent antidepressant efficacy of Yueju and ketamine in chronically stressed mice and its association with alternations in prefrontal N-methyl-D-aspartate (NMDA) receptor and mammalian target of rapamycin (mTOR)-related activity. Chronic mild stress (CMS) led to deficits in sucrose preference test (SPT), forced swim test, tail suspension test, and novelty-suppressed feeding test, which were improved differently by acute Yueju or ketamine administration. The improvement in SPT started as soon as 2 hours post Yueju and ketamine but lasted for 6 days only by Yueju. Body weight was regained by Yueju more than ketamine at post-drug administration day (PAD) 6. CMS decreased phosphorylation of the mTOR effectors 4E-BP1 and p70S6K, their upstream regulators ERK and Akt, and downstream targets including synaptic protein GluR1. Yueju or ketamine reversed these changes at PAD 2, but only Yueju reversed phosphor-Akt at PAD 6. CMS selectively and lastingly increased NMDA receptor subunit NR1 expression, which was reversed by ketamine or Yueju at PAD 2 but only by Yueju at PAD 6. These findings suggest that NR1 and Akt/mTOR signaling are important therapeutic targets for depression.

 

http://www.ncbi.nlm....pubmed/26825573

 

 

Accumulating evidence indicated that N-methyl-D-aspartate (NMDA) receptors are involved in the pathophysiology of depression and implicated in therapeutic targets. NMDA antagonists, such as ketamine, displayed fast-onset and long-lasting antidepressant activity in preclinical and clinical studies. Previous studies showed that Yueju pill exerts antidepressant effects similar to ketamine. Here, we focused on investigating the association of acute and lasting antidepressant responses of Yueju with time course changes of NMDA receptor subunits NR1, NR2A, and NR2B expressions in the hippocampus, a key region regulating depression response. As a result, Yueju reduced immobility time in the forced swimming test from 30 min to 5 days post a single administration. Yueju acutely decreased NR1 and NR2B protein expression in the hippocampus, with NR2A expression unaltered. NR1 expression remained down-regulated 5 days post Yueju administration, whereas NR2B returned to normal level in 24 h. Yueju and ketamine similarly ameliorated the depression-like symptoms at least for 72 h in learned helplessness test. They both reversed the up-regulated expression of NR1 in the learned helpless mice 1 or 3 days post administration. Different from ketamine, the antidepressant effects of Yueju were not influenced by blockade of amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor. These findings served as preclinical evidence that Yueju may confer acute and long-lasting antidepressant effects by favorably modulating NMDA function in the hippocampus.

 

http://www.ncbi.nlm....les/PMC4551989/

 

Yueju, a Traditional Chinese Medicine formula, exhibited fast-onset antidepressant responses similar to ketamine. This study focused on assessing the rapid and persistent antidepressant efficacy of Yueju and ketamine in chronically stressed mice and its association with alternations in prefrontal N-methyl-D-aspartate (NMDA) receptor and mammalian target of rapamycin (mTOR)-related activity. Chronic mild stress (CMS) led to deficits in sucrose preference test (SPT), forced swim test, tail suspension test, and novelty-suppressed feeding test, which were improved differently by acute Yueju or ketamine administration. The improvement in SPT started as soon as 2 hours post Yueju and ketamine but lasted for 6 days only by Yueju. Body weight was regained by Yueju more than ketamine at post-drug administration day (PAD) 6. CMS decreased phosphorylation of the mTOR effectors 4E-BP1 and p70S6K, their upstream regulators ERK and Akt, and downstream targets including synaptic protein GluR1. Yueju or ketamine reversed these changes at PAD 2, but only Yueju reversed phosphor-Akt at PAD 6. CMS selectively and lastingly increased NMDA receptor subunit NR1 expression, which was reversed by ketamine or Yueju at PAD 2 but only by Yueju at PAD 6. These findings suggest that NR1 and Akt/mTOR signaling are important therapeutic targets for depression.

 

 

 

http://www.ncbi.nlm....pubmed/27108051

 

 

Both petroleum ether (GJ-PE) and n-butyl alcohol fraction (GJ-BO) fractions of GJ displayed rapid antidepressant potential in the FST. In the TST, the antidepressant effects of GJ-PE lasted for a longer time than GJ-BO. Acute administration of either GJ-PE or GJ-BO significantly reversed the behavioral deficits in the tests of TST, FST, SPT and NSF in chronically stressed mice, confirming both fractions conferred rapid antidepressant efficacy. Interestingly, GJ-PE, but not GJ-BO, increased the expression of BDNF and TrkB in the hippocampus post a single administration.Two standardized fractions GJ-PE and GJ-BO exhibited comparable rapid antidepressant-like effects in the CMS mice. However, only the effects of GJ-PE was associated with BDNF signaling.

 

 

I'd be willing buy the extract that you have; but the thing is that I have been taking Yue Ju Wan TCM decoction for 3 months now. It has helped only slightly, no where near as effective as ketamine.

 

I actually have stopped taking it now but I might start taking it again.

Edited by MoreNowAgain, 05 May 2016 - 09:34 PM.