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What is causing mania?

supplements mania depression

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11 replies to this topic

#1 AnygirlX

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Posted 04 April 2014 - 04:26 PM


I've taken prozac off and on, but mostly on, for the last 7 years. I've never had any abnormal side effects. Recently I've started adding some supplements and other things. I'm not sure what is doing it, but this is a smart group of people so I thought I'd ask. I am diagnosed with major depressive disorder and ADD, not bipolar. I feel like that has been an accurate diagnosis, but recently with my current medications and supplements something is sending me into a kind of hypomanic state. It's not necessarily unenjoyable, but I can tell that something is off. My thoughts are racing, I can't focus, I get paranoid, I can't complete a task, I'm having great ideas and realizations but I can't focus enough to do anything with them. At the same time I get completely caught up in what I'm doing and forget everything else. It's hard to explain, but I'm fairly certain this is a case of mania. So here's what I'm taking.

40mg Prozac
100-200mg Wellbutrin (I've stopped that the last day or so to see if it makes a difference)
180mg Baclofen (I take high doses of baclofen to combat alcoholism)
14g Kratom (7g morning and 7g early evening for pain)
500mg DMAE
500mg Rhodiola
500mg Taurine (with 10mg B6)
Ashwagandha
333mg Dopa Bean
2g inositol
100mg 5-HTP
60mg Gingko Biloba
600mg NAC
1500mg GABA
1g Hydrolyzed fish collagen
400mg magnesium
10mg bioperine
200mg L-Theanine
B complex
2000 IU Vitamin D
multi vitamin

It's probably that multi vitamin isn't it ; )
I'm also running about 16-20 miles/week, 2 yoga classes a week, the mother of a 3 year old, and I have a very demanding job. If there's any suggestions that anyone has about things I should be taking or shouldn't be or thoughts on what is causing the mania I would really appreciate your feedback.

#2 YOLF

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Posted 05 April 2014 - 12:50 AM

Wasn't there a group buy going on a for an experimental MDD drug? IIRC it's a vast improvement and has passed the safety/efficacy portions of the trials. Was that NSI-189?

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#3 AnygirlX

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Posted 05 April 2014 - 02:43 AM

Wow! Thank you. I've never heard of this. I'm really excited.

#4 Luminosity

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Posted 05 April 2014 - 06:23 AM

I'd ask the doctor that prescribed the drugs.

#5 Mr. Pink

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Posted 05 April 2014 - 06:35 PM

My comments are in caps bellow; i am not yelling, just trying to help. Really hope you figure it out. If I had to take a guess, I'd say inositol.

40mg Prozac
100-200mg Wellbutrin (I've stopped that the last day or so to see if it makes a difference) - DON'T STOP WITHOUT DOCTOR'S INFORMED INPUT (I MEAN TELL THE DOC EVERYTHING YOU'RE TAKING BEFORE ASKING TO CEASE THE WELLBUTRIN)
180mg Baclofen (I take high doses of baclofen to combat alcoholism) - OFFTOPIC (MAYBE): THIS IS A MUSCLE RELAXANT AND HELPS WITH PHYSICAL DEPENDENCE ON ALCOHOL; ALCOHOLISM HAS A MUCH LARGER PSYCHOLOGICAL COMPONENT; THE BEST TREATMENT IS ACTIVELY WORKING A 12 STEP PROGRAM AND COMPLETELY STOPPING USE OF ALL RECREATIONAL DRUGS INCLUDING ALCOHOL AND WEED; CONSIDER HOW MUCH YOU DRINK AND OTHER RECREATIONAL DRUGS YOU DO WHEN TRYING TO NARROW DOWN THE SOURCE OF THE MANIA
14g Kratom (7g morning and 7g early evening for pain) - THIS IS PSYCHOACTIVE AS I UNDERSTAND, SIMILAR TO OPIATES; SOMETHING TO LOOK AT IF YOU'RE AN ALCOHOLIC
500mg DMAE
500mg Rhodiola
500mg Taurine (with 10mg B6)
Ashwagandha
333mg Dopa Bean - NOT SURE WHAT IT IS, BUT IF IT'S L-DOPA - THE PRODRUG FOR DOPAMINE THAT CAN CROSS THE BLOOD BRAIN BARRIER, THIS IS SOMETHING TO LOOK AT, AS WELL AS LOTS OF OTHER HEALTH DANGERS (MANIA, PSYCHOSIS, ETC)
2g inositol - THIS CAN CAUSE MANIA, SEARCH AROUND THE BOARDS HERE
100mg 5-HTP - HOPE YOU'RE TAKING SOME GREEN TEA WITH IT FOR YOUR HEART'S SAKE
60mg Gingko Biloba
600mg NAC
1500mg GABA
1g Hydrolyzed fish collagen
400mg magnesium
10mg bioperine
200mg L-Theanine
B complex
2000 IU Vitamin D
multi vitamin

#6 AnygirlX

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Posted 05 April 2014 - 11:21 PM

Thank you Mr. Pink, I will certainly read more on the effects of inositol. I have worked a 12 step program of recovery with a sponsor who has a sponsor and so on, but I do not find it to be a complete solution. I am aware of the addiction potential of kratom, but it is a better solution than much stronger and highly addictive narcotic pain killers that are normally prescribed to me. I have chosen this as the lesser of two evils that allows me to function and do the things that keep me healthy like running and yoga. I do take breaks from the kratom to combat tolerance. I dose two times a day with a set amount and never exceed the dosage I set for myself. Why is green tea necessary for the 5-HTP? I have also started taking L-Theanine 100mg 1-2x/day. Would that work as well? I really appreciate the thoughtful response.

Luminosity, My psychiatrist is aware of all the medications and supplements I take, but has been very straightforward about his ignorance concerning the supplements. I have an appointment with him scheduled and already plan on discussing this with him. I'm not quite sure why you bothered to reply to my post. It wasn't a helpful or insightful response and actually sounds bad-mannered.

Edited by Anonygurl, 05 April 2014 - 11:22 PM.


#7 YOLF

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Posted 05 April 2014 - 11:27 PM

You might think about getting a LEF.org subscription. You should be able to their medical professionals and the subscription is $75/year.

#8 Mr. Pink

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Posted 06 April 2014 - 02:36 AM

Thank you Mr. Pink, I will certainly read more on the effects of inositol. I have worked a 12 step program of recovery with a sponsor who has a sponsor and so on, but I do not find it to be a complete solution. I am aware of the addiction potential of kratom, but it is a better solution than much stronger and highly addictive narcotic pain killers that are normally prescribed to me. I have chosen this as the lesser of two evils that allows me to function and do the things that keep me healthy like running and yoga. I do take breaks from the kratom to combat tolerance. I dose two times a day with a set amount and never exceed the dosage I set for myself. Why is green tea necessary for the 5-HTP? I have also started taking L-Theanine 100mg 1-2x/day. Would that work as well? I really appreciate the thoughtful response.

Luminosity, My psychiatrist is aware of all the medications and supplements I take, but has been very straightforward about his ignorance concerning the supplements. I have an appointment with him scheduled and already plan on discussing this with him. I'm not quite sure why you bothered to reply to my post. It wasn't a helpful or insightful response and actually sounds bad-mannered.


5-htp is bad for the heart if it gets converted into seratonin in the gut. green tea inhibits the enzyme that does that so that it will get converted in the brain and not cause heart problems. read the below link around 5.2

http://examine.com/s...HTP/#summary5-1

#9 Jeoshua

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Posted 06 April 2014 - 03:40 AM

If you are doing things that cause you pain, you should stop causing yourself pain, rather than finding a chemical way of masking said pain. If you're running until you need painkillers, you are overdoing it. As a matter of fact, you're overdoing quite a lot, here. There are only a few people who have posted such a long and detailed every day stack, and one of them is a body builder going for superhuman levels of everything.

Most doctors have been trained to think of supplements as "nothing", and "no big deal", and "completely ineffectual, so nothing to worry about".

They have been trained to think wrong. The medications you have voluntarily decided to take in such high amounts are leaps and bounds more active than the amount of welbutrin you have been prescribed. I'm not surprised you're experiencing mania, I'm surprised you're not experiencing something worse.

#10 penisbreath

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Posted 06 April 2014 - 05:07 AM

My guess is the Rhodiola plus SSRI. Someone else reported becoming hypomanic on the combination.
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#11 lammas2

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Posted 06 April 2014 - 07:34 AM

40mg Prozac
100-200mg Wellbutrin
333mg Dopa Bean


This.

Fluoxetine/Prozac is a 5-HT2C antagonist, which means it acts as a norepinephrine-dopamine disinhibitor (increases NA/DA release). Wellbutrin is a dopamine reuptake inhibitor. Dopa Bean/L-DOPA is a dopamine precursor that readily crosses the blood-brain barrier. So it all comes down to excessive dopaminergic stimulation.
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#12 AnygirlX

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Posted 06 April 2014 - 11:37 AM

Thank you! Just the sort of responses I was hoping for.
Jeoshua, I really enjoy the running. I stopped last year because of the pain and inflammation. That was the beginning of a year long depressive episode. I gained a good deal of weight and ended up with similar problems because of the weight. The running is also great for my mental health. Maybe I should try to be more balanced and instead of increasing my distance/time anymore focus on what I'm doing that is causing the pain? I don't know but, your feedback is appreciated on this because obviously my thinking tends toward pushing it too far. What would you recommend I cut back or remove amongst the medications/supplements?
lucky.pierre, I too wondered about the Rhodiola. I thought I read somewhere that it could do that in people predisposed to mania. Thank you.
lammas2, I think you're on to something. I cut out the Wellbutrin mostly because of a feeling I had, but I didn't really understand why. Do you know what I mean? Like I had a little tickeling in the back of my brain, probably based on something I'd read but couldn't recall easily. Otherwise I feel like my "stack" (I can not get used to saying this word with out feeling like a meat head and wanting to follow it up with, "hey man, I've got this totally killer stack and I'm going to Pump. Some. Iron!") is working very nicely. I am productive at work, motivated, have patience and energy for home, etc. Your response was ideal, you didn't judge me. You didn't make sweeping generalizations. You simply looked at the information, processed it, and made a recommendation. Thank you for your help.

Edited by Anonygurl, 06 April 2014 - 11:39 AM.






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