13 replies to this topic

[Stanfoo]

I would say I'm a non responder to stims/nootropics, as both caffeine and Phenylpiracetam has no effect on me. I'm wondering what are the chances of Adrafinil working for me? It's not your normal stim/nootropic so I'm being hopeful. All I want from it is to keep me awake.

Edited by Stanfoo, 20 April 2014 - 08:16 AM.

[ZHMike]

Yea it should, although modafinil would do a better job.. the adrafinil would be worth a shot..I would dose 600-900 mg in the Am on an empty stomach.  good luck, let us know how it goes for you

[ModaMinds]

Can I ask how long you tried phenylpiracetam? Many people say they get no effect, but they also say they only used it for a day or so. Many racetams have a crescendo effect in which you won't notice full results until up to a week or two after beginning continuous use.

 

Adrafinil metabolizes into modafinil, so best to just address modafinil here. Caffeine and modafinil don't work exactly in the same way, but caffeine does have dopaminergic-like effects, so it's possible that your lack of response to caffeine may indicate your potential response to modafinil. However, I personally believe modafinil is much stronger than caffeine - i.e. one pill would yield the effects of countless cups of coffee without the jitter and other negative side-effects. Note that if you use adrafinil, you'll have some delayed effects as your body has to first metabolize adrafinil into modafinil, whereas you don't have this grace period when starting immediately with modafinil. We can supply you a small 30ct order of modafinil from ModaMind.

[Stanfoo]

Yea it should, although modafinil would do a better job.. the adrafinil would be worth a shot..I would dose 600-900 mg in the Am on an empty stomach.  good luck, let us know how it goes for you

 

I should be getting it on Tues, will update on Wed.

 

Can I ask how long you tried phenylpiracetam? Many people say they get no effect, but they also say they only used it for a day or so. Many racetams have a crescendo effect in which you won't notice full results until up to a week or two after beginning continuous use.

 

Adrafinil metabolizes into modafinil, so best to just address modafinil here. Caffeine and modafinil don't work exactly in the same way, but caffeine does have dopaminergic-like effects, so it's possible that your lack of response to caffeine may indicate your potential response to modafinil. However, I personally believe modafinil is much stronger than caffeine - i.e. one pill would yield the effects of countless cups of coffee without the jitter and other negative side-effects. Note that if you use adrafinil, you'll have some delayed effects as your body has to first metabolize adrafinil into modafinil, whereas you don't have this grace period when starting immediately with modafinil. We can supply you a small 30ct order of modafinil from ModaMind.

 

I've tried Phenylpiracetam for the past 3 days now. Day 1, 100mg, Day 2, 300mg, Day 3, 400mg, all at around 10-11PM. I could not notice anything different in me. I took it primarily for the wakefulness effect but did notice it, and had no troubles sleeping.

 

Regarding Adrafinil, I'm just looking to get a good 5 hours out of it (midnight to 5AM, then I go to sleep afterards). What would be a good time to take the dose to accomplish this? And would 300mg suffice?

[ModaMinds]

 

Yea it should, although modafinil would do a better job.. the adrafinil would be worth a shot..I would dose 600-900 mg in the Am on an empty stomach.  good luck, let us know how it goes for you

 

I should be getting it on Tues, will update on Wed.

 

Can I ask how long you tried phenylpiracetam? Many people say they get no effect, but they also say they only used it for a day or so. Many racetams have a crescendo effect in which you won't notice full results until up to a week or two after beginning continuous use.

 

Adrafinil metabolizes into modafinil, so best to just address modafinil here. Caffeine and modafinil don't work exactly in the same way, but caffeine does have dopaminergic-like effects, so it's possible that your lack of response to caffeine may indicate your potential response to modafinil. However, I personally believe modafinil is much stronger than caffeine - i.e. one pill would yield the effects of countless cups of coffee without the jitter and other negative side-effects. Note that if you use adrafinil, you'll have some delayed effects as your body has to first metabolize adrafinil into modafinil, whereas you don't have this grace period when starting immediately with modafinil. We can supply you a small 30ct order of modafinil from ModaMind.

 

I've tried Phenylpiracetam for the past 3 days now. Day 1, 100mg, Day 2, 300mg, Day 3, 400mg, all at around 10-11PM. I could not notice anything different in me. I took it primarily for the wakefulness effect but did notice it, and had no troubles sleeping.

 

Regarding Adrafinil, I'm just looking to get a good 5 hours out of it (midnight to 5AM, then I go to sleep afterards). What would be a good time to take the dose to accomplish this? And would 300mg suffice?

 

 

Are you sure you need a stim for just five hours? Seems like maybe several cups of coffee or even a 5-Hour Energy (though I need two of these to get five hours...) would be fine. 300mg of adrafinil is going to be too much for 5 hours. Maybe even 100mg-200mg would be fine. I would take it an hour to an hour-and-a-half prior unless you're on an empty stomach, in which case the metabolization process won't take as long.

[Stanfoo]

Are you sure you need a stim for just five hours? Seems like maybe several cups of coffee or even a 5-Hour Energy (though I need two of these to get five hours...) would be fine. 300mg of adrafinil is going to be too much for 5 hours. Maybe even 100mg-200mg would be fine. I would take it an hour to an hour-and-a-half prior unless you're on an empty stomach, in which case the metabolization process won't take as long.

 

I've tried a boatload of supplements/stimulants meant to give energy/keep a person mentally awake and none have worked, including caffeine pills and 5 hr energy, so coffee probably wouldn't do anything for me either (I don't drink coffee in the first place, lol).

 

I'd like to try Adrafinil first, but if for some reason it doesn't work, I will try Modafinil.

[ModaMinds]

 

Are you sure you need a stim for just five hours? Seems like maybe several cups of coffee or even a 5-Hour Energy (though I need two of these to get five hours...) would be fine. 300mg of adrafinil is going to be too much for 5 hours. Maybe even 100mg-200mg would be fine. I would take it an hour to an hour-and-a-half prior unless you're on an empty stomach, in which case the metabolization process won't take as long.

 

I've tried a boatload of supplements/stimulants meant to give energy/keep a person mentally awake and none have worked, including caffeine pills and 5 hr energy, so coffee probably wouldn't do anything for me either (I don't drink coffee in the first place, lol).

 

I'd like to try Adrafinil first, but if for some reason it doesn't work, I will try Modafinil.

 

 

Also I should mention that the 100mg-200mg estimate is based on usual dosages, but if you don't respond well to stims, you may need a higher dose. You should set up an environment in which you can safely test dosages apart from the 12am-5am time frame so that you can see how long its effects last on you.

Edited by ModaMind, 20 April 2014 - 09:05 PM.

[FW900]

 

Yea it should, although modafinil would do a better job.. the adrafinil would be worth a shot..I would dose 600-900 mg in the Am on an empty stomach.  good luck, let us know how it goes for you

 

I should be getting it on Tues, will update on Wed.

 

Can I ask how long you tried phenylpiracetam? Many people say they get no effect, but they also say they only used it for a day or so. Many racetams have a crescendo effect in which you won't notice full results until up to a week or two after beginning continuous use.

 

Adrafinil metabolizes into modafinil, so best to just address modafinil here. Caffeine and modafinil don't work exactly in the same way, but caffeine does have dopaminergic-like effects, so it's possible that your lack of response to caffeine may indicate your potential response to modafinil. However, I personally believe modafinil is much stronger than caffeine - i.e. one pill would yield the effects of countless cups of coffee without the jitter and other negative side-effects. Note that if you use adrafinil, you'll have some delayed effects as your body has to first metabolize adrafinil into modafinil, whereas you don't have this grace period when starting immediately with modafinil. We can supply you a small 30ct order of modafinil from ModaMind.

 

I've tried Phenylpiracetam for the past 3 days now. Day 1, 100mg, Day 2, 300mg, Day 3, 400mg, all at around 10-11PM. I could not notice anything different in me. I took it primarily for the wakefulness effect but did notice it, and had no troubles sleeping.

 

Regarding Adrafinil, I'm just looking to get a good 5 hours out of it (midnight to 5AM, then I go to sleep afterards). What would be a good time to take the dose to accomplish this? And would 300mg suffice?

 

 

Modafinil has a half life of over 12 hours and is active effective for combating sleepiness for roughly that period of time. Adrafinil is a prodrug of modafinil- it would be metabolized more slowly, adding to the duration of how long it would affect you for. (For another comparison: Vyvsane, which is a prodrug of d-amphetamine, has a longer duration than d-amphetamine simply due to the prolonged metabolization of a prodrug). In theory adrafinil, would last much longer than 5 hours.

[ModaMinds]

 

 

Yea it should, although modafinil would do a better job.. the adrafinil would be worth a shot..I would dose 600-900 mg in the Am on an empty stomach.  good luck, let us know how it goes for you

 

I should be getting it on Tues, will update on Wed.

 

Can I ask how long you tried phenylpiracetam? Many people say they get no effect, but they also say they only used it for a day or so. Many racetams have a crescendo effect in which you won't notice full results until up to a week or two after beginning continuous use.

 

Adrafinil metabolizes into modafinil, so best to just address modafinil here. Caffeine and modafinil don't work exactly in the same way, but caffeine does have dopaminergic-like effects, so it's possible that your lack of response to caffeine may indicate your potential response to modafinil. However, I personally believe modafinil is much stronger than caffeine - i.e. one pill would yield the effects of countless cups of coffee without the jitter and other negative side-effects. Note that if you use adrafinil, you'll have some delayed effects as your body has to first metabolize adrafinil into modafinil, whereas you don't have this grace period when starting immediately with modafinil. We can supply you a small 30ct order of modafinil from ModaMind.

 

I've tried Phenylpiracetam for the past 3 days now. Day 1, 100mg, Day 2, 300mg, Day 3, 400mg, all at around 10-11PM. I could not notice anything different in me. I took it primarily for the wakefulness effect but did notice it, and had no troubles sleeping.

 

Regarding Adrafinil, I'm just looking to get a good 5 hours out of it (midnight to 5AM, then I go to sleep afterards). What would be a good time to take the dose to accomplish this? And would 300mg suffice?

 

 

Modafinil has a half life of over 12 hours and is active effective for combating sleepiness for roughly that period of time. Adrafinil is a prodrug of modafinil- it would be metabolized more slowly, adding to the duration of how long it would affect you for. (For another comparison: Vyvsane, which is a prodrug of d-amphetamine, has a longer duration than d-amphetamine simply due to the prolonged metabolization of a prodrug). In theory adrafinil, would last much longer than 5 hours.

 

 

Correct, if taking a dosage of adrafinil (300mg) that's roughly the equivalent of modafinil (200mg). However, keep in mind he doesn't respond well to stims meaning he'll likely need a higher dose, and I also recommended he only take 100mg-200mg of adrafinil to see the duration, which should be far shorter than the max duration.

[Introspecta]

Adrafinil will leave you awake well beyond 5 hours. I felt its effects for well over 12 hours my first time yesterday.

[Stanfoo]

Adrafinil will leave you awake well beyond 5 hours. I felt its effects for well over 12 hours my first time yesterday.

 

At what dosage?
 

[Ritchie]

I'm just wondering, why can't you stay awake? Do you have narcolepsy? Or just really sever chronic daytime fatigue?

If you feel tired and you don't know why try to see a sleep doctor, it could be sleep apnea in which case a c-pap machine should eliminate your fatigue.

Before you try any stimulants, try looking a precursors. Dopamine and Adrenalin precursors such as L-tyrosine(Weak) and Mucuna Pruriens(Strong) could help, maybe your brain is simply depleted of adrenalin.

[FW900]

I'm just wondering, why can't you stay awake? Do you have narcolepsy? Or just really sever chronic daytime fatigue?

If you feel tired and you don't know why try to see a sleep doctor, it could be sleep apnea in which case a c-pap machine should eliminate your fatigue.

Before you try any stimulants, try looking a precursors. Dopamine and Adrenalin precursors such as L-tyrosine(Weak) and Mucuna Pruriens(Strong) could help, maybe your brain is simply depleted of adrenalin.

 

The OP mentioned he wanted to stay up till 5:00am without tiring in another thread.

 

Sleep doctors can take months to arrange an appointment with, an MSLT is usually not cheap, and if you do not do "well" on the MSLT, it "rules out" that you have a sleep disorder. I find it amazing that people take multiple naps a day, are immune to coffee, can fall asleep behind the wheel, and sleep can 12 hours straight, have to go through such a lengthy process simply to pursue even basic treatment such as modafinil. Yet, a condition like ADHD people are given neurotoxic stimulants right off the bat, without any tests (aside from a basic questionnaire). In terms of treating (not related to sleep apnea) excessive daytime sleepiness, it's best to educate yourself and see if it can be treated with supplements/drugs you can legally buy before visiting a doctor; simply because visiting a doctor is not a guarantee that you will be treated in any fashion for sleepiness.

 

I have not read much indicating that either L-Tyrosine or L-Dopa can combat fatigue. If you have used either to treat excessive daytime sleepiness, how effective would you say they are? Do you have a sleep disorder (if you don't mind me asking)? Also, I don't see how a brain can 'simply be depleted' of norepinephrine--I do not think that this is the case for the OP or people with sleep disorders.

[Ritchie]

 

I'm just wondering, why can't you stay awake? Do you have narcolepsy? Or just really sever chronic daytime fatigue?

If you feel tired and you don't know why try to see a sleep doctor, it could be sleep apnea in which case a c-pap machine should eliminate your fatigue.

Before you try any stimulants, try looking a precursors. Dopamine and Adrenalin precursors such as L-tyrosine(Weak) and Mucuna Pruriens(Strong) could help, maybe your brain is simply depleted of adrenalin.

 

The OP mentioned he wanted to stay up till 5:00am without tiring in another thread.

 

Sleep doctors can take months to arrange an appointment with, an MSLT is usually not cheap, and if you do not do "well" on the MSLT, it "rules out" that you have a sleep disorder. I find it amazing that people take multiple naps a day, are immune to coffee, can fall asleep behind the wheel, and sleep can 12 hours straight, have to go through such a lengthy process simply to pursue even basic treatment such as modafinil. Yet, a condition like ADHD people are given neurotoxic stimulants right off the bat, without any tests (aside from a basic questionnaire). In terms of treating (not related to sleep apnea) excessive daytime sleepiness, it's best to educate yourself and see if it can be treated with supplements/drugs you can legally buy before visiting a doctor; simply because visiting a doctor is not a guarantee that you will be treated in any fashion for sleepiness.

 

I have not read much indicating that either L-Tyrosine or L-Dopa can combat fatigue. If you have used either to treat excessive daytime sleepiness, how effective would you say they are? Do you have a sleep disorder (if you don't mind me asking)? Also, I don't see how a brain can 'simply be depleted' of norepinephrine--I do not think that this is the case for the OP or people with sleep disorders.

 

Oh, sorry I did not see the other thread that the OP posted. I do not have a sleep disorder no, but increasing catecholamines supposedly promotes release or at the very least makes stimulants(which affect adrenaline or dopamine) more effective. What i meant by adenalin depletion is does the op have a catecholamines deficiency or has he used a lot of stimulants in the past that may have desensitized his post sypnatic receptors.