5 replies to this topic

[misterE]

Leptin is a hormone secreted from adipocytes. The amount of triglycerides stored within the adipocyte determines the amount of leptin it manufactures. Leptin is an anabolic hormone that has important functions regarding satiety, metabolism, fertility, skeletal system and cardiovascular system and defects in the leptin axis can impair those benefits. I also personally believe that leptin promotes beauty as well.

 When the adipocyte is accumulating triglycerides, the adipocyte enlarges and the amount of leptin it produces starts to increase, the leptin then goes on to promote growth and repair. However when the adipocyte is losing its collection of triglycerides, the amount of leptin it makes starts to decrease.

Lipolysis is the release of stored fat into the blood. When the body is undergoing lipolysis (like what you see in low-carb diets, diabetes, or starvation), the amount of free-fatty-acids (FFA) increases and leptin production decreases. The increased level of FFAs then impairs the binding of leptin to the receptor-sites. This is where ''leptin-resistance'' comes from.

 

Insulin and leptin are strongly linked together and both hormones cannot work without one another. Insulin inhibits lipolysis and promotes the storage of fat inside the adipocyte, which increases the amount of leptin and leptin in turn increases insulin-sensitivity (among many other things). That is what happens in healthy metabolism.

 

 In a person with diabetes or a person undergoing starvation, you have insulin-resistance within the adipocyte, which causes increased lipolysis and fat burning. As the subcutaneous fat stores become depleted, the amount of leptin is reduced and any leptin left in the body becomes resistant because of the high levels of FFAs. Of course this makes sense because leptin being a satiety hormone decreases the amount of food you crave, well if your fat-stores are becoming depleted, leptin decreases and becomes resistant in order to make you really hungry and eat more calories in an attempt to restore you fat-stores, which evolutionarily was beneficial because it meant you could live longer during famines.

 

It's clear to me now that anything that inhibits lipolysis (carbohydrates, alcohol and acipimox for example) will in turn increase leptin and vice-versa.

Edited by misterE, 05 May 2014 - 02:06 AM.

[Believer]

There are many reasons a high carb (or starch), low fat diet works for weight loss. Thyroid hormones, metabolism, and maybe leptin.

[Nate-2004]

This PhD researcher on insulin function would strongly disagree with your uncited statements.

 

[misterE]

This PhD researcher on insulin function would strongly disagree with your uncited statements.

 

 

 

 

Yeah, eating fatty-foods and avoiding high-fiber complex-carbohydrates is a great way to promote insulin and leptin-sensitivity {rolls eyes}. Even if it were true (which it flat-out isn't) low-carb diets are high in pollutants (PCBs and dioxins) and unsustainable for the planet, so it cannot and never will work. Many studies show that low-carb diets high in animal-products increase your risk of all sorts of diseases, especially CVD, yet NO studies to the contrary show that diets based on whole-grains is harmful, in fact diets based on whole-grains reverse CVD, as show by Ornish, Pritikin, Esselstyn and others. And lets not forget that ketosis occurs with diabetes and if left unmanaged you enter a state of ketoacidosis, which can be deadly!

 

 

 

 

 

[misterE]

Here Nate, watch this 2 min video and explain away these facts:

 

[Nate-2004]

 

This PhD researcher on insulin function would strongly disagree with your uncited statements.

 

 

 

 

Yeah, eating fatty-foods and avoiding high-fiber complex-carbohydrates is a great way to promote insulin and leptin-sensitivity {rolls eyes}. Even if it were true (which it flat-out isn't) low-carb diets are high in pollutants (PCBs and dioxins) and unsustainable for the planet, so it cannot and never will work. Many studies show that low-carb diets high in animal-products increase your risk of all sorts of diseases, especially CVD, yet NO studies to the contrary show that diets based on whole-grains is harmful, in fact diets based on whole-grains reverse CVD, as show by Ornish, Pritikin, Esselstyn and others. And lets not forget that ketosis occurs with diabetes and if left unmanaged you enter a state of ketoacidosis, which can be deadly!

 

 

Dude, you're ridiculously ill informed about what the low carb keto diet even involves. Who said ANYTHING at all about avoiding high fiber complex carbs?? Every single critic and bit of research I read seems to make this straw man argument. A low carb diet is a *high* fiber diet that is mostly fat, and not even necessarily animal fat, coconuts, walnuts, almonds, avocados, all these have high fats. Every single low carb book out there talks about all the veggies you need. Hell, your body gets a little depleted of magnesium, potassium and other electrolytes so spinach is high on that list. In fact you need to keep net (not total) carbs down but that necessarily involves eating plenty of plant based foods. Animal fat is not going to hurt either especially if you include a diet full of vitamin E rich foods like walnuts and almonds. These take care of the glucose spikes and peroxidation that happens. Even Dr. Greger makes this same argument. There's a holy f* ton of evidence supporting its benefits including what that guy is talking about in the video. I've been on and off keto all year and my lab work just came in and I gotta say it's really looking good compared to last year.

 

Getting a little sick of the straw men about low carb.

Edited by Nate-2004, 10 February 2018 - 05:22 AM.