• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Could Chronic Uridine Use Depress Dopamine Receptors?

uridine dopamine receptor depression

  • Please log in to reply
2 replies to this topic

#1 Phoenicis

  • Guest
  • 339 posts
  • 79
  • Location:-
  • NO

Posted 12 May 2014 - 02:03 AM


Hi, a trusted source has drawn my attention the possibility that chronic uridine use stimulates dopamine receptors similarly to cocaine and thus may depress their number. What do you guys think?

 

Chronic uridine treatment reduces the level of [3H]spiperone-labelled dopamine receptors and enhances their turnover rate in striatum of young rats: relationship to dopamine-dependent behaviours

 

The effect was studied of chronic uridine treatment on the recovery of striatal D-2 dopamine (DA) receptors after their irreversible blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) in young (40 days old) and adult (14 months old) male rats using [3H]spiperone as radioligand. Chronic uridine treatment (15 mg kg-1 day-1, i.p., 14 days) causes a reduction of [3H]spiperone binding sites in striatum of young rats. This treatment also produces an increase in the rate of recovery of striatal [3H]spiperone-labelled DA receptors in young, but not in adult rats. Catalepsy and exploratory locomotor activity, two behaviours associated with blockade versus activation of DA receptors, were evaluated in the same rats. The behavioural recovery from the EEDC^induced syndrome is more rapid in the young rats treated with uridine than in the saline-treated group. The behavioural recovery in old rats was not affected by chronic uridine treatment. Thus, in young rats the pyrimidine nucleoside uridine may modulate the steady state and the turnover rate of striatal D-2 DA receptors.

 

Edited by Phoenicis, 12 May 2014 - 02:05 AM.

  • like x 1

#2 thegenie

  • Guest
  • 1 posts
  • 0
  • Location:USA

Posted 18 May 2014 - 02:10 AM

Bump. Would also be interested to see what some more intelligent/knowledgeable members here have to say on this subject. I am currently supplementing Uridine myself.



sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#3 Arjuna

  • Guest
  • 130 posts
  • 31
  • Location:International Waters

Posted 27 May 2014 - 03:10 PM

That sounded like uridine helped, at-least in the young rats.





Also tagged with one or more of these keywords: uridine, dopamine receptor, depression

1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users