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Safety study in humans

human resveratrol

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#1 malbecman

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Posted 02 June 2014 - 03:44 PM


I know a lot of interest has died out here in resveratrol but there still are a number of ongoing studies coming out in Pubmed.

Here's one that just came out:

 

 

Exp Gerontol. 2014 May 24. pii: S0531-5565(14)00176-4. doi: 10.1016/j.exger.2014.05.015. [Epub ahead of print]
Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study.
Abstract

Resveratrol has been found to have potent antioxidant, anti-inflammatory, and anticarcinogenic effects. The safety and efficacy of resveratrol supplementation in older adults are currently unknown. We conducted a double-blind, randomized, placebo-controlled trial to examine the safety and metabolic outcomes in 32 overweight, older adults (mean age, 73±7years). Participants were randomized into one of three treatment groups: (1) placebo, (2) moderate dose resveratrol (300mg/day), and (3) high dose resveratrol (1000mg/day). Both resveratrol and placebo were orally ingested in capsule form twice daily for 90days. Blood chemistry values remained within the normal range, and there were no significant differences in the number of participants reporting adverse events across conditions. Compared to placebo, glucose levels were significantly lower at post-treatment among participants randomized to both resveratrol conditions, with and without adjustment for the corresponding baseline values (ps<0.05). Glucose values of participants in the treatment groups, however, were not significantly different from baseline levels. These findings suggest that short-term resveratrol supplementation at doses of 300mg/day and 1000mg/day does not adversely affect blood chemistries and is well tolerated in overweight, older individuals. These findings support the study of resveratrol for improving cardio-metabolic health in older adults in larger clinical trials.

Copyright © 2014. Published by Elsevier Inc.

KEYWORDS:

Blood pressure; Glucose; Metabolism; Resveratrol; Safety

PMID: 24866496  





Also tagged with one or more of these keywords: human, resveratrol

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