Posted 15 June 2014 - 03:55 PM
I don't mean to promote here; but, EVP-6124 just became commercially availabe at a popular nootropic vendor. (Omitting mentioning to avoid promoting companies, as a matter of discretion with all the other vendors out there today.) Anyway, awesome stuff as nothing bad in healthy competition, eh? Can't wait to see some more a7n-partial agonists/PAM's.
Edited by yadayada, 15 June 2014 - 04:16 PM.
Posted 15 June 2014 - 05:55 PM
The price is very high though. I would be willing to try it if they half the price. I am not affiliated with any nootropic vendors, I don't see anything with saying that it is in fact newmind that is stocking this. Of course if there were many different vendors suggesting newmind over others vendors would be "promoting".
Edited by telight, 15 June 2014 - 05:55 PM.
Posted 15 June 2014 - 07:45 PM
Haven't it been available for a while (atleast a few days) now?
You should also probably respond to the ISRIB thread.
I have nothing to say there. The money was burned through and no positive effects on cognition were reported from some anecdotal evidence. That group buy is closed, as in it never happened. And, I'm still not in the Bahamas drinking pina coladas.
Posted 15 June 2014 - 10:49 PM
This ain't good news in my view, significant commercial interest of a high profile patented drug is just going to attract unwanted attention.
It's of my opinion that potent agonists and high profile compounds should be kept personal and small within group buys here, otherwise it's just a matter of time before someone gets in trouble by law or by simply taking too much.
Edited by Dazzcat, 15 June 2014 - 11:26 PM.
Posted 16 June 2014 - 01:07 AM
I don't recall discussion about retailers ever being prohibited. For those curious, this is in stock at Newmind. Assuming it is pure, it will cost around $3.44 per dose of 1 mg (1 mg according to the Alzheimer's study on the product page). I would not assume it is pure, at least with the information currently provided.
Be warned, there is no third party CoA provided, no HPLC chromatogram provided, and lastly there is no H-NMR spectra provided; these are all ways of confirming the product is pure that most retailers like Ceretropic, NSN, Nootropics Depot provide for every product. This means there is no way to confirm the product is "98%" pure as there website puts it or if it actually is EVP-6124. I'd avoid this retailer at all costs until they decide to have third party testing of the compound.
With enough pressure from the nootropics community as a whole, Newmind will be forced to use third-party testing or lose their business to retailers who do.
Posted 16 June 2014 - 11:07 PM
I;m much more interested in GTS-21, if and when it becomes available. Haven;t seen such a promising nootropic in a while.
Acording to the primary paper behind EVP-6124, there is only so much an agonist can evoke inward current at the a7 nicotinic receptor before we see receptor desensitization, so I can't see how GTS-21 would bring anything new to the table.
Posted 17 June 2014 - 02:22 AM
Dunno when they added this, but must've been recently: https://newmind.com/sen12333.html
Posted 17 June 2014 - 03:37 AM
Dunno when they added this, but must've been recently: https://newmind.com/sen12333.html
I looked at the rodent study they did with this drug, the effect size looks really small and disappointing. Still, I hope someone here decides to try it and report back.
Edited by telight, 17 June 2014 - 03:37 AM.
Posted 18 June 2014 - 04:58 PM
This is strange that we have almost no feedback on EVP-6124. If I am not mistaken then the group buy of EVP-6124 here has delivered the EVP-6124 for US participants weeks ago and we still don’t have much feedback. I have still my fingers crossed that the EU participants (inc me) will get their EVP-6124 from Hungarian customs.
Posted 18 June 2014 - 09:30 PM
People need to realize when it comes to some of these substances that not every cognitive enhancer is going to give overt noticeable high-like effects. A good compound for instance would improve on efficiency of cognitive development. If such a compound were taken and the consumer does not actively do anything that would push the brain to expand in very noticable/challenging ways, then it will be very difficult to notice much at all. I get the feeling a lot of the people taking these substances are just looking for the quick-boost, automatic enhancement, etc.
Posted 18 June 2014 - 11:52 PM
Do you know the dosage on these things? If not, I'm assuming you work up day to day from a microgram dosage?
The HED from rats (3mg/kg) is around 35mg for a 70kg person. So, 40mg seems safe bet.
Interesting thing about WAY, is the concurrent H3 agonism, given possibly its similar structure to Pitolisant and other H3 agonists/autoreceptor blockers.
Posted 19 June 2014 - 12:01 AM
Do you know the dosage on these things? If not, I'm assuming you work up day to day from a microgram dosage?
The HED from rats (3mg/kg) is around 35mg for a 70kg person. So, 40mg seems safe bet.
Interesting thing about WAY, is the concurrent H3 agonism, given possibly its similar structure to Pitolisant and other H3 agonists/autoreceptor blockers.
Do be aware that rats generally require higher concentrations, for whatever reason. For instance, what is considered a therapeutic adderall/amphetamine dosage for rats is about 4x greater than the therapeutic concentration for humans. The therapeutic dose for rats was considered an abuse dose for humans if I'm not mistaken. While rats and humans are both mammals it is important to keep in mind that our bodies are proportioned in different ways.
Posted 20 July 2017 - 07:52 PM
Do you know the dosage on these things? If not, I'm assuming you work up day to day from a microgram dosage?
The HED from rats (3mg/kg) is around 35mg for a 70kg person. So, 40mg seems safe bet.
Interesting thing about WAY, is the concurrent H3 agonism, given possibly its similar structure to Pitolisant and other H3 agonists/autoreceptor blockers.
Do be aware that rats generally require higher concentrations, for whatever reason. For instance, what is considered a therapeutic adderall/amphetamine dosage for rats is about 4x greater than the therapeutic concentration for humans. The therapeutic dose for rats was considered an abuse dose for humans if I'm not mistaken. While rats and humans are both mammals it is important to keep in mind that our bodies are proportioned in different ways.
Metabolism.
Rats have an exponentially more potent metabolism than us - they are frighteningly active, all the time. This metabolism is one of the reasons why they can so quickly adapt to toxins and become immune to some forms of rat-poison.
They also grow much, much faster than us, as a result of this powerful metabolism.
They burn through the drugs far, far faster than us humans.
Most peeps seem unaware of this, even though only a cursory knowledge of rodents makes it obvious why they would likely need higher dosages per kilo than humans...
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