Beta-endorphins do have their benefits, and they are released during running "creating the runner's high" and during other repetitive cardiotonic / aerobic exercises...the only issue with the concept of enhancing beta-endorphin, is that we don't know entirely what the side-effects can be and long-term effects on the HPG axis are questionable, and in some cases, worrysome.
Beta-endorphin is meant to be released naturally from activities, and while opiate antagonism has it's benefits, it can also have some downsides...
This mainly is reflected in opiate users who end up having their hormones shut down. Can result in sexual dysfunction and infertility, as well as memory issues...on the other hand, selectively antagonizing/blocking certain opiate receptors at the proper affinity, can enhance hormone release if enough is done.
Therefore it depends on how you do it, nociceptin is virtually incapable of being blocked as no drugs have been developed and released to specifically block it or at high affinity.
Mu-opioid which represents a high affinity target for both natural beta-endorphin and for dynorphin's that are released, can have many downsides to being over-activated, including but not limited to hyperthermia or hypOthermia, and depression and concentration issues..in many cases, it's actually better to antagonize the receptor..
KAPPA activation causes dysphoria in many instances, so antagonizing it with amentoflavone may be a good idea while experimenting with endorphin enhancement.