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Poll on next group buy for novel rapid acting antidepressants.

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8 replies to this topic

Poll: Antidepressants (22 member(s) have cast votes)

Which of the following or unmentioned below would you like to see synthesized?

  1. ISX-9 (1 votes [4.55%])

    Percentage of vote: 4.55%

  2. Ro 25-6981 (6 votes [27.27%])

    Percentage of vote: 27.27%

  3. CERC 301 (0 votes [0.00%])

    Percentage of vote: 0.00%

  4. 4'-dimethylamino-7,8-dihydroxyflavone (5 votes [22.73%])

    Percentage of vote: 22.73%

  5. NRX-1074 (4 votes [18.18%])

    Percentage of vote: 18.18%

  6. P7C3A20 (2 votes [9.09%])

    Percentage of vote: 9.09%

  7. Hydroxynorketamine (4 votes [18.18%])

    Percentage of vote: 18.18%

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#1 Reformed-Redan

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Posted 21 June 2014 - 06:45 AM


I've spoken with THT and they've mostly confirmed that 1,2, and 4 would be feasible to make. I'm pretty sure Ro 25-6981 is the one to go with until we know what the structure of NRX is. Any other interesting candidates I haven't mentioned? Not sure if there would be issues with legality for producing Hydroxynorketamine, nor how long would the effects last. 

 

Personally, I'd love to see ISX-9 and Ro 25-6981, the most. Thoughts? 


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#2 Reformed-Redan

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Posted 22 June 2014 - 04:41 PM

Lol, looks like everyone wants a little of everything. Why not synthesize them all? Hehe.


Edited by yadayada, 22 June 2014 - 04:41 PM.

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#3 tolerant

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Posted 17 July 2014 - 06:27 AM

What is the difference between 7,8-dihydroxyflavone and 4'-dimethylamino-7,8-dihydroxyflavone? Also, what is the correct name/CAS for Hydroxynorketamine? Is it (2S,6S)-hydroxynorketamine? I will request quotes for some of these substances from a local lab.


Edited by tolerant, 17 July 2014 - 06:41 AM.


#4 Flex

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Posted 17 July 2014 - 05:20 PM

For me are the advantages of i4'-dimethylamino-7,8-dihydroxyflavone negligible compared to 7,8-dihydroxyflavone.

I´m not a big fan in using too much Research chemicals.

If something goes wrong, You would not know the cause.

Furthermore the consideration of natural compounds, which are used since a long time, lacks.

 

Btw, who would lead this Group buy ?

 

 


Edited by Flex, 17 July 2014 - 06:12 PM.

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#5 tolerant

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Posted 18 July 2014 - 10:48 AM

Is there anybody here with enough knowledge of chemistry to have a look at this patent together with the enclosed paper and determine the definite structure of hydroxynorketamine that would have to be synthesised? I am particularly confused that the paper identifies the (2S, 6S) version, yet the patent (which was filed by authors of the paper) focuses on the (2R, 6R) version.

Attached Files


Edited by tolerant, 18 July 2014 - 10:52 AM.


#6 knockout_mice

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Posted 18 July 2014 - 02:41 PM

http://journals.lww....ine_and.26.aspx

 

In the current study, (2S,6S)-hydroxynorketamine was used instead of (2R,6R)-hydroxynorketamine or the racemic mixture, a decision based on data indicating that this isomer was the most potent of the three compounds in the suppression of intracellular D-serine levels (unpublished data from preliminary in vitro study obtained following previously described protocol14 provided by Irving W. Wainer, Ph.D., D.H.C., Baltimore, Maryland, August 2013) and its availability in our laboratory.

 

 


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#7 NinefingerJoe

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Posted 05 March 2015 - 06:44 PM

Personally I would love to see how P7C3A20
could be used as an adjunct to a neurogenic cycle (NSI189 Cerebrolysin etc).

New neurons are most likely to die off quickly but according to research P7C3A20 could in theory aid in ensuring a maximal survival rate.

Follow it all up with a synaptogenic Dihexa cycle and…

Think about it.
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#8 plumper76

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Posted 23 June 2016 - 06:53 AM

I read about P7C3 compounds if we could get that synthesized I'd be very game.

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#9 Ark

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Posted 23 June 2016 - 03:09 PM

Ro 25-6981 Please!!!





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