4 replies to this topic

[Aurel]

1.) From my understandings one of the benefits of exercising is, that it actually kills the unfit mitochondria in the cells trough the exess amount of ROS. Thus leaving the more fit mitochondria behind, which then will produce their "offspring".

2.) C60 is a scavenger hunter, yes, but it seems that the major benefit is, that it changes the charge of mitochondria membrane, so that it is better protected from outside influence in the first place.

 

IF (!!!) both off these assumptions are correct, wouldnt it be better for an unfit individual (like me), to do some high intensity workouts/cardio before starting with the C60 regime? Otherwise it could protect some rather unfit mitochondria for some time.

[YOLF]

Good point, interesting question.

[Turnbuckle]

You might find these papers of interest--

 

Natural selection of mitochondria during somatic lifetime promotes healthy aging

Effects of Exercise on Mitochondrial Content and Function in Aging Human Skeletal Muscle

 

Taken together, they suggest you might be right. On the other hand, it's unknown how exactly C60 is improving the function of mitochondria. If it's by some epigenetic mechanism, then it's not clear whether treatment would be better before or after an exercise regime. The epigenetics of mtDNA is quite complex, and involves crosstalk with nDNA--

 

Mitochondrial regulation of epigenetics and its role in human diseases

 

Some mitochondrial dysfunction is likely epigenetic, and if C60 has some effect on the epigenetic coding (perhaps by inhibiting methyltransferase) then intermittent treatment would be best, as it would allow natural selection to amplify the best functioning mitochondria after random demethylation. Intermittent treatment might be best no matter what the actual mechanism is. If C60 protects the functioning of mitochondria, then daily treatment would lessen the selection pressure and might actually have a long term negative effect on a cell's mitochondrial population. (A no-child-left-behind effect.)

[YOLF]

Let me start by saying that I'm not an expert. 

 

I've thought that given any random racemix of cytoplasm and C60's strong affinity for ROS that it would attach to whatever structures particle physics would allow for and then attract ROS to itself and thus the structure it is attached to causing that structure to fail and require replacement.

 

AFAIAA, there is no conflict with this and other theories.

[Yeshe Rabsal]

(A no-child-left-behind effect.)

 

LOL