9 replies to this topic

[necrobytez]

I've read that l-theanine reduces nicotine reward feeling. I use swedish snus as a nootropic and i find it as a miracle drug and ever since i took l-theanine supplement i feel like i don't really get any reward from snus anymore, could be placebo but is there any way to revert it back as i enjoy(ed) snus very much.

 

You can google l-theanine nicotine on google if you want to find out more.

Edited by necrobytez, 17 July 2014 - 03:49 AM.

[Turnbuckle]

L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway.

 

 

 

In this study, the inhibitory effect of L-theanine, an amino acid derivative of tea, on the rewarding effects of nicotine and its underlying mechanisms of action were studied. We found that L-theanine inhibited the rewarding effects of nicotine in a conditioned place preference (CPP) model of the mouse and reduced the excitatory status induced by nicotine in SH-SY5Y cells to the same extent as the nicotine receptor inhibitor dihydro-beta-erythroidine (DHβE). Further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the midbrain of mice. L-theanine treatment also reduced the upregulation of the α(4), β(2) and α(7) nicotine acetylcholine receptor (nAChR) subunits induced by nicotine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. In addition, L-theanine treatment inhibited nicotine-induced c-Fos expression in the reward circuit related areas of the mouse brain. Knockdown of c-Fos by siRNA inhibited the excitatory status of cells but not the upregulation of TH induced by nicotine in SH-SY5Y cells. Overall, the present study showed that L-theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway. These results may offer new therapeutic strategies for treatment of tobacco addiction.

 

 

[necrobytez]

Anyone?

[necrobytez]

Will this l-theanine effect that it has done be reversed in time? Like it says it reduces very important receptors for working memory etc which i really need. I use swedish snus and i used to love it to death but after i used l-theanine it has kind of dissipated. Is there some way to reverse this effect or will it go away with time? I know this is silly but i had cognitive dysfunction and nicotine really helped me out.

[Area-1255]

 

L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway.

 

 

 

In this study, the inhibitory effect of L-theanine, an amino acid derivative of tea, on the rewarding effects of nicotine and its underlying mechanisms of action were studied. We found that L-theanine inhibited the rewarding effects of nicotine in a conditioned place preference (CPP) model of the mouse and reduced the excitatory status induced by nicotine in SH-SY5Y cells to the same extent as the nicotine receptor inhibitor dihydro-beta-erythroidine (DHβE). Further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the midbrain of mice. L-theanine treatment also reduced the upregulation of the α(4), β(2) and α(7) nicotine acetylcholine receptor (nAChR) subunits induced by nicotine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. In addition, L-theanine treatment inhibited nicotine-induced c-Fos expression in the reward circuit related areas of the mouse brain. Knockdown of c-Fos by siRNA inhibited the excitatory status of cells but not the upregulation of TH induced by nicotine in SH-SY5Y cells. Overall, the present study showed that L-theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway. These results may offer new therapeutic strategies for treatment of tobacco addiction.

 

 

 

Very interesting stuff, I believe NAC - N-AcetylCysteine is effective as well, if I recall correctly it's by reducing Glutamate levels and thus providing less of an additive tendency and more dopamine.

 

Wellbutrin is another nicotinic antagonist - part of the reason why it's an aphrodisiac is because it stops nicotinic induced vasoconstriction and thus improves circulation. The very same reason and enhanced N.O levels by wellbutrin plus DopamineReuptake inhibition can lead to reversal of cognitive deficits induced by nicotine and a relief of depression to go with that. Wellbutrin also may synergise with Caffeine and can be included as part of a before exam focus stack. 

 

Although adderall is usually used more for this purpose. 

For some reason I actually liked wellbutrin much more than Adderall. :o

[necrobytez]

 

L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway.

 

 

 

In this study, the inhibitory effect of L-theanine, an amino acid derivative of tea, on the rewarding effects of nicotine and its underlying mechanisms of action were studied. We found that L-theanine inhibited the rewarding effects of nicotine in a conditioned place preference (CPP) model of the mouse and reduced the excitatory status induced by nicotine in SH-SY5Y cells to the same extent as the nicotine receptor inhibitor dihydro-beta-erythroidine (DHβE). Further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the midbrain of mice. L-theanine treatment also reduced the upregulation of the α(4), β(2) and α(7) nicotine acetylcholine receptor (nAChR) subunits induced by nicotine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. In addition, L-theanine treatment inhibited nicotine-induced c-Fos expression in the reward circuit related areas of the mouse brain. Knockdown of c-Fos by siRNA inhibited the excitatory status of cells but not the upregulation of TH induced by nicotine in SH-SY5Y cells. Overall, the present study showed that L-theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway. These results may offer new therapeutic strategies for treatment of tobacco addiction.

 

 

 

Is it likely this will go away in time and will upregulate and feel satisfaction again?

[Turnbuckle]

 

 

L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway.

 

 

 

In this study, the inhibitory effect of L-theanine, an amino acid derivative of tea, on the rewarding effects of nicotine and its underlying mechanisms of action were studied. We found that L-theanine inhibited the rewarding effects of nicotine in a conditioned place preference (CPP) model of the mouse and reduced the excitatory status induced by nicotine in SH-SY5Y cells to the same extent as the nicotine receptor inhibitor dihydro-beta-erythroidine (DHβE). Further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that L-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (TH) expression and dopamine production in the midbrain of mice. L-theanine treatment also reduced the upregulation of the α(4), β(2) and α(7) nicotine acetylcholine receptor (nAChR) subunits induced by nicotine in mouse brain regions that related to the dopamine reward pathway, thus decreasing the number of cells that could react to nicotine. In addition, L-theanine treatment inhibited nicotine-induced c-Fos expression in the reward circuit related areas of the mouse brain. Knockdown of c-Fos by siRNA inhibited the excitatory status of cells but not the upregulation of TH induced by nicotine in SH-SY5Y cells. Overall, the present study showed that L-theanine reduced the nicotine-induced reward effects via inhibition of the nAChR-dopamine reward pathway. These results may offer new therapeutic strategies for treatment of tobacco addiction.

 

 

 

Is it likely this will go away in time and will upregulate and feel satisfaction again?

 

 

 

I imagine it will go away with time, but in you're in a hurry, you might look for supplements or drugs that enhance addiction. One would be THC, as in the gateway drug effect--

 

The findings obtained here suggest that a history of cannabis exposure might have lasting effects that increase the risk of becoming addicted to nicotine--http://www.nature.co...npp201316a.html

 

 

Note that this research comes from a governmental drug abuse research group, so it might be propaganda.

[necrobytez]

Weed didn't work out for me :( any other suggestions? 

[Turnbuckle]

Weed didn't work out for me :( any other suggestions? 

 

 

The answer might lie in post no. 5 above. If lowering glutamate decreases addiction, increasing it should do the reverse. Thus foods rich in glutamate like certain cheeses, MSG, or aspartame, should increase nicotine cravings. Also, look at how much niacin you are taking, as niacin decreases the desire for nicotine, at least for some--

[necrobytez]

L-theanine definetely messed up the reward feeling, so is there any supplement that could help?