All the available studies suggest that the decrease in methionine ingestion that occurs during DR is responsible for part of the aging-delaying effect of this intervention likely through the decrease of mtROSp and ensuing DNA damage that it exerts.
http://www.ncbi.nlm....pubmed/23454735
When they talk about reducing methionine by 40% I suppose they mean with respect to the diet of the controls (or one of the standardized mice chow diet?) ? I suppose that the benefits observed depend heavily on how much methionine is present in the control's diet..
Ie if you start with a bodybuilder-like protein intake and reduce methionine by 40% you would still have a methionine intake above most people. Why dont they make statements more accurate, perhaps something like decreasing methionine intake below x grams per day per kg of body weight, or below x grams per calorie ingested
