3 replies to this topic

[Phoenicis]

Weird story - I was worried I might have brain cancer because I was suffering from unusual headaches and was worried this might be connected some kind of bcl-2 interruptions caused by the use of rasagiline to boost GDNF 2 months ago (1.5mg / day).

 

Anyways I remembered reading that Longvida phospholipid curcumin was being used for Alzheimers trials and found 4g Longvida (8 caps) should give you .22uM/L free curcumin; which should be on the edge of clinical efficacy for alzheimers.[1] The fluorescent curcumin has actually even been observed binding to the amyloid plaques be using retinal scans. [2]

 

I decided to take it as a cancer preventative, the idea was to ensure that bcl-2 induction wasn't somehow stuck 'on' from the rasagiline. I was pleasantly surprised after the third day, when I found that my ability to concentrate was much better than usual. I could read lengthy articles more quickly than usual, while still understanding the concepts. I haven't done any cognitive tests, but the headaches are now gone.

 

[1] http://truttmd.com/c...-created-equal/ referencing: Gota et al. Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers J. Agric. Food Chem., 2010, 58 (4), pp 2095–2099 http://pubs.acs.org/doi/abs/10.1021/jf9024807

 

[2] Chin et al., Neuroprotective Properties of Curcumin in Alzheimer's Disease - Merits and Limitations, Current Medicinal Chemistry, Volume 20, Number 32, October 2013, pp. 3955-3985(31).

Edited by Phoenicis, 22 July 2014 - 02:57 PM.

[88LS]

Any update?

[resveratrol_guy]

I'm taking 6.4 grams (16 pills) per day. But in the interest of keeping threads lean, I'll be discussing this more in this thread.

[Ruth]

bump
https://www.hindawi....18/9041309/abs/
Posttraumatic stress disorder (PTSD) is a trauma-induced psychiatric disease characterized by impaired hyperarousal, fear extermination, depression, anxiety, and amnesic symptoms that may include the release of monoamines in the dread circuit. Curcumin (CUR), a major diarylheptanoid and polyphenolic component of Curcuma longa, reportedly possesses several pharmacological features, including antidiabetic, antiatherosclerotic, anticancer, and neuropsychiatric actions. But the anxiolytic-like effects of CUR and its mechanism of action in PTSD are unclear. The current research measured some anxiety-related behavioral responses to examine the effects of CUR on symptoms of anxiety in rats after single prolonged stress (SPS) exposure by reversing the serotonin (5-HT) dysfunction. Rats received CUR (20, 50, or 100 mg/kg, i.p., once daily) for 14 days after SPS exposure. Administration of CUR significantly increased the number of central zone crossings in the open field test and reduced grooming behavior in the elevated plus maze (EPM) test and increased the number of open-arm visits on the EPM test. CUR administration significantly reduced freezing response to contextual fear conditioning. CUR recovered neurochemical abnormalities and SPS-induced decreased 5-HT tissue levels in the hippocampus, amygdala, and striatum. These results suggested that CUR has anxiolytic-like effects on biochemical and behavioral symptoms associated with anxiety. Thus, CUR may be a useful agent to alleviate or treat psychiatric disorders similar to those observed in patients with PTSD