4 replies to this topic

[Metagene]

I don't think previous L-clausenamide thread received enough attention so I'll place the link here http://www.longecity...rbal-piracetam/

 

Is there any chance that a nootropic vendor could make (-)-Clausenamide available?

 

 

"Clausenamide is isolated from the leaves of Clausena lansium (lour) Skeels in the family of Rutaceae [67]. Animal studies demonstrated that L-clausenamide is capable of improving the spatial discrimination disorders of rats induced by Aβ via enhancing the activities of cholineacetyltransferase of the cortex (68). Further, L-clausenamide promoted the release of glutamic acid from synaptosomes of cerebellum, enhanced the amplitude of long term potentiation (LTP) in the hippocampus CA1 zone, and increased cerebral cortex thickness, thereby improving learning and memory ability of rats (68). It was demonstrated that the nootropic effect of L-clausenamide is more potent than that of piracetam (44)."

 

Drug Discoveries & Therapeutics. 2013; 7(2):46-57. 

 

 

 

Study on the nootropic mechanism of clausenamide

"There is a close relationship between monoamines and learning and memory. NE and dopamine are believed to have a role in facilitation of memory. For this, an observation of clausenamide on monoamines and their metabolites as well as monoamine oxidase B activity was carried out.

Successive oral administration of clausenamide at dosage of 30, 150mg/kg d-1 for 4 day. Norepinephrine (NE) , dopamine (DA) , serotonin (5-HT) and their metabolities DOPAC, HAV, 5HIAA in mouse cerebral cortex were measured by HPLC -ECD. The result showed that clausenamide at dosage of 30mg/kg could increase the DA content significantly."

150mg/kg of (-)-Clausenamide caused an increase in content of NE, DA, 5-HT, while their metabolities DOPAC and 5HIAA decreased. Clausenamide had no obvious effect on monoamine oxidase B activity using HPLC-UV detector, indicating that increment of monoamines may involves another mechanism of action. The increase of monoamine induced by clausenamide could be attributed to its increase of intracellular DA"

 

"Administration of (-) clausenamide at dosage of 5, 10, 20mg/kg to weaning mice for 4 weeks. reduced gain of body weight was seen in the first week, but there was no difference in the gain of body weight between control and medicated groups in the next three weeks. It is interesting that chronic administration of (-) clausenamide induced facilitation of learning and memory in step down and step through tests. In the mean time, thickness of cerebral cortex and synapses density in the hippocampal region increased significantly."

 

 

(-)-Clausenamide potentiates synaptic transmission in the dentate gyrus of rats.

 

https://drive.google...dit?usp=sharing

 

Mechanism of (-)clausenamide induced calcium transient in primary culture of rat cortical neurons.

 

https://drive.google...dit?usp=sharing

 

 

 

Its tons more information to cover on this one.
 

[medicineman]

increasing cortical thickness is what caught my attention. I'd love a few inches of extra cortical thickness.

Edited by medicineman, 27 July 2014 - 09:17 PM.

[Metagene]

(-)Clausenamide increased the activity of ChAT and protein content in cultured neurons, as well as stimulated proliferation of neuronal cells, support survival and neurite outgrowth of neurons. The neurotrophic action of (-)clausenamide (0.001-10 mumol.L-1) was similar to that of nerve growth factor.

https://docs.google....sp=docslist_api

The cortical neurons and granule and pyramide cells in hippocampus of normal rats show a large of BDNF(brain derived neurotrophine factor). levoclausenamide (8, 40 50 mg-kg_1) orally-administrated daily for 10 days, dose dependently increased the BDNF protein expression in the cortical neurons and pyramide cells in the hippocampus, but (+) clausenamide showed slightly increasing effect only at a dose of 40mg~kg_1,suggesting that the different effects of 55 (—),(+)clausenamide on hippocampal synaptic transmission maybe related to their differentactions on the BDNF protein expression.

http://www.google.co...1348696B1?cl=en

Edited by Metagene, 27 July 2014 - 11:34 PM.

[William Sterog]

One of the most interesting herbal compounds for me, alongside with Bacopa and Polygala Tenuifolia.

www.sciencedirect.com/science/article/pii/S2211383514001038

Edited by William Sterog, 25 March 2016 - 09:50 AM.

[gintrux]

Very interested, anyone tried it?