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How to reduce cholinergic effect of otherwise beneficial substances?

choline cholinergic anticholinergic dopamine

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#1 R.ticle One

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Posted 29 July 2014 - 07:51 PM


Recently I began using Ecklonia Cava (a 98% extract), primarily for purported its anti-inflammatory properties. That it may help the endothelial system and be good for hair grow (or loss prevention) are nice bonuses.

 

However, it seems (from what I've read, and from how it makes me feel) to posses some kind of cholinergic property - can't remember if it increases acetylcholine or inhibits acetylcholinesterase - but I found that when I take it, I feel hazy, dull and kind of depressed. Things - life, in genera - tend to look kind of "flat" and feel "slow".

 

I've also experienced this with Butea Superba (I think it inhibits acetylcholinesterase) and Intellect Tree seed oil (dose dependent cholinergic) - so I think that elevated acetylcholine and I don't get along too well. I feel similar with Bacopa.

 

It's worth mentioning that I have HPPD (for 12 years or so) and some anxiety issues.

 

It's too bad, because I noticed a distinct reduction in knee pain within several days of using the Ecklonia Cava extract...but I couldn't take the (presumably) increased choline levels. I assume the anti-inflammatory properties have nothing to do with any cholinergic effect - so what I wonder is:

 

Is there a safe way to reduce the cholinergic/actetylcholinesterase-inhibiting effect of this and other cholinergic substances while retaining their other benefits?

 

I think I've read that dopamine and choline have an inverse relationship - so would taking, say, L-Tyrosine along with Ecklonia Cava allow the latter to exert its benefits without the unwanted mental effects? Or do I have no idea what I'm talking about?

 

Given the HPPD, I have to be careful about what I take.

 

Thoughts are appreciated.

 

 



#2 GreenmachineX

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Posted 01 May 2018 - 12:48 PM

Couple years later, any update on this?

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#3 HighDesertWizard

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Posted 09 May 2018 - 09:30 AM

Turns out... I'm . into . triggeringacetylcholine...

 

:|?

 

I imagine I must also be doing something that reduces the negative impact of having too much acetylcholine flowing...

 

In a study easily found in a google search, Piracetam was found to increase Muscarinic Acetylcholine Receptor Density. I do regularly take Aniracetam, perhaps that's it. I also load up on other nootropics. Dunno, and it's important to know.

 

Via this Tracey study, we know it's almost certainly important to trigger acetylcholine at least twice daily...

 

You don't mention whether you're attempting to hit the Nicotinic or Muscarinic Acetylcholine Receptors...

 

We should brainstorm and experiment together on finding a good answer to this question... I"m certainly going to continue trying to consciously trigger acetylcholine expression, whether by an actetylcholinesterase, or not...

 

I take it from the first study here that Ecklonia Cava pings Muscarinic Acetylcholine Receptors...

 

 

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Edited by HighDesertWizard, 09 May 2018 - 09:50 AM.






Also tagged with one or more of these keywords: choline, cholinergic, anticholinergic, dopamine

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