Hi all,
I have been reading up on Piracetam glutamate toxicity and I was wondering would N-Acetyl L Cysteine be a good way to mop up the excess glutamate or would that defeat the purpose of using Piracetam?
Posted 29 July 2014 - 09:51 PM
Hi all,
I have been reading up on Piracetam glutamate toxicity and I was wondering would N-Acetyl L Cysteine be a good way to mop up the excess glutamate or would that defeat the purpose of using Piracetam?
Posted 30 July 2014 - 12:08 AM
Possibly because glutamate excitotoxicity doesn't work the way most people assume that it does. It's definitely true that high levels of glutamate are toxic to neurons under certain conditions. But those conditions are generally very different from an intact brain.
Alternatively, in the intact brain, piracetam doesn't work the way people think it does.
Posted 30 July 2014 - 01:09 AM
Edited by Duchykins, 30 July 2014 - 01:11 AM.
Posted 30 July 2014 - 10:07 AM
there isn't one paper showing that piracetam is toxic in most (if not all) circumstances. there are studies on cell cultures showing that oxidative damage maybe an issue if used in large doses (over three grams daily hed I think).
why do some healthy individuals sometimes complain of cognitive issues/brain fog etc. with piracetam? I think it was summarized well by some neuroscientist in quora who said :
Possibly because glutamate excitotoxicity doesn't work the way most people assume that it does. It's definitely true that high levels of glutamate are toxic to neurons under certain conditions. But those conditions are generally very different from an intact brain.
Alternatively, in the intact brain, piracetam doesn't work the way people think it does.
The substance Piracetam itself is not toxic but it's effects over time are, calcium influx and the over stimulation of NMDA receptors are the two mechanisms of concern. When I was in Thailand a few months ago I went to a doctor for food poisoning and decided to ask him about Piracetam since it's popular in Thailand. The doctor told me that he has used the medicine for over 23 years in TBI cases and that Piracetam should not be taken for longer than 6 months as it's healing effects follow a U curve into excitotoxicity. He explained to me that is the reason why Piracetam is not the miracle drug most people think it is.
I stopped using Piracetam after this as this reflected other Longecity users concerns and the concerns of my Psychiatrists who looked into Piracetam for me.
Piracetam worked wonders for me indeed but I did listen to each side objectively and concluded that most of the studies people on Longecity quote showing Piracetam to be safe were not double blind and not of long enough duration.
Posted 30 July 2014 - 02:38 PM
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